Prenatal diagnosis of fetal urinary tract abnormalities by ultrasound

Cass, Alexander S.; Krishna, Veeraraghavan,; Smith, Suzanne J.; Tsai, Shih Hung; Godec, Ciril J.; Bendel, Richard P.

doi:10.1016/0090-4295(81)90442-8

Cited by 14 publications

(4 citation statements)

References 13 publications

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“…In two of our cases (Fig. 14) and a case reported previously, 4 there was pathologic confusion as to whether the renal mass was hydronephrosis or whether there were areas of dysplasia. It is now widely accepted that multicys tic kidney represents a s tage in the progression of complete obstruction of the ureter occurring in utero.…”

Section: Discussionmentioning

confidence: 49%

Twelve cases of hydronephrosis in utero diagnosed by ultrasonography.

Sanders¹,

Graham²

1982

Journal of Ultrasound in Medicine

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Twelve examples of hydronephrosis in utero, seven of which were bilateral, were seen at the Johns Hopkins Hospital. Unexpected findings on sonographic examination were: 1) two cases of transient hydronephrosis of moderate severity, persisting over several examinations, which disappeared spontaneously; 2) only two of six examples of ureteropelvic junction obstruction were detected by palpation by competent neonatologists at the time of delivery; 3) polyhydramnios in association with bilateral ureteropelvic junction obstruction was observed in one case and had been reported twice previously (two cases of the prune belly syndrome, however, were associated with oligohydramnios); 4) two examples of a mixed pattern of hydronephrosis and multicystic kidney were seen.

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Section: Discussionmentioning

confidence: 49%

Twelve cases of hydronephrosis in utero diagnosed by ultrasonography.

Sanders¹,

Graham²

1982

Journal of Ultrasound in Medicine

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“…Additional longitudinal and extended family studies utilizing renal ultrasonography are needed in order to provide this information. The prenatal ultrasonographic diagnosis of renal agenesis and cystic dyplasia has been reported by several investigators [Kaffe et al, 1976;Bartley et al, 1977;Cass et al, 1981;Dubbins et al, 1981;Hadlock et al, 1981;Schmidt et al, 19821. High-resolution ultrasound studies should be offered to all such families to monitor for recurrence beginning at 16 weeks gestation.…”

Section: Possible Teratogenic Disruptionsmentioning

confidence: 93%

The Potter sequence: A clinical analysis of 80 cases

et al. 1984

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Eighty cases of Potter sequence due to a renal or urologic abnormality were studied retrospectively. The abnormal renal findings were bilateral renal agenesis in 21.25%; cystic dysplasia in 47.5%; obstructive uropathy in 25%; and others in 5.25%. Fifteen patients had multiple congenital anomalies; of these three had aneuploidy, four had autosomal recessive syndromes, and eight were of unknown cause. Results of chromosome analysis in 41 patients and 21 sets of parents were abnormal in three patients, one of whom had a balanced translocation carrier parent; two additional patients and three parents had apparently balanced translocations. There was one recurrence within the study (the first child had bilateral renal agenesis and the second cystic dysplasia). The ultrasound prenatal diagnosis of the renal abnormality was made in eight cases between 18 and 34 weeks. Family histories were suggestive of an autosomal dominant gene disorder with incomplete penetrance in four of 45 families with nonsyndromic bilateral renal agenesis and cystic dysplasia. The evaluation of patients with the Potter sequence should include an examination for nonrenal defects, autopsy, chromosome analysis, and renal ultrasound or urologic evaluation of parents. Ultrasonographic prenatal monitoring of subsequent pregnancies in such families is strongly warranted because of a definite but unknown degree of recurrence risk.

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“…Until now eleven papers [1,5,8,10,11,12,14,15,19,20,21] reported a total of 36 cases of fetal hydronephrosis presumably not due to low urinary tract obstruction with controlled neonatal outcomes. Therapeutic abortions were performed in two cases, postnatal surgery in twenty, severe associated malformations occurred in five cases and neonatal mortality was 14% mostly due to malformations other than hydronephrosis.…”

Section: Discussionmentioning

confidence: 99%

Perinatal management of fetal hydronephrosis with normal bladder

Nicolini¹,

Ferrazzi²,

Kustermann

et al. 1987

Journal of Perinatal Medicine

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This report covers 30 cases of prenatal diagnosis of uni- or bilateral hydronephrosis not associated with an overdistended bladder. Oligohydramnios was observed only in four cases while polyhydramnios occurred in three affected fetuses. In no case was fetal urine aspirated or drained prenatally. Early delivery was performed in four cases with oligohydramnios. Sixteen newborns required surgical correction of the lesion as it was confirmed by urography, following at least two sonographic examinations which confirmed a moderate to severe hydronephrosis after birth. The most frequent lesion was pyelo-ureteric junction obstruction (12 cases). Thirteen cases were normal at follow-up, and in two of these the dilation cleared up during intrauterine life. One case of severe hydronephrosis proved to be a multicystic kidney. In this series isolated hydronephrosis, both uni- or bilateral did not result in fetuses being at high risk for survival (only one infant died after surgery) nor as regards to associated malformations and perinatal morbidity. Provided a properly timed surgical correction was performed, renal function resulted to be good at follow-up.

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Prenatal diagnosis of fetal urinary tract abnormalities by ultrasound

Cited by 14 publications

References 13 publications

Twelve cases of hydronephrosis in utero diagnosed by ultrasonography.

Twelve cases of hydronephrosis in utero diagnosed by ultrasonography.

The Potter sequence: A clinical analysis of 80 cases

Perinatal management of fetal hydronephrosis with normal bladder

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