Prenatal diagnosis of interchromosomal insertion of Y chromosome heterochromatin in a family

Lee, Bom-Yi; Park, Ju Yeon; Lee, Jin‐Choon; Oh, Ah-Rum; Lee, Shin-Young; Park, So‐Yeon; Ryu, Hyun-Mee; Lee, Si-Won

doi:10.5734/jgm.2017.14.2.62

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…The interaction of alkyl-substituted gem-diboronates with bulky amide bases has been studied by Cho and coworkers and the corresponding lithiated products have been characterized by NMR spectroscopy and applied in a host of synthetic chemistries. 29 Related "-ate" complexes and deborylated compounds have also been generated from alkyl gemdiboronates and identified by NMR spectroscopy. 3a,4a,5b By contrast, few studies have been conducted on the interaction of benzyldiboronates with the bases used in this study.…”

Section: Mechanistic Studiesmentioning

confidence: 99%

Ketone Synthesis from Benzyldiboronates and Esters: Leveraging α-Boryl Carbanions for Carbon–Carbon Bond Formation

Lee

Chirik

2020

J. Am. Chem. Soc.

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An alkoxide-promoted method for the synthesis of ketones from readily available esters and benzyldiboronates is described. The synthetic method is compatible with a host of sterically differentiated alkyl groups, alkenes, acidic protons α to carbonyl groups, tertiary amides and aryl rings having common organic functional groups. With esters bearing α-stereocenters, high enantiomeric excess was maintained during ketone formation, establishing minimal competing racemization by deprotonation. Monitoring the reaction between benzyldiboronate and LiO t Bu in THF at 23 °C allowed for the identification of products arising from deborylation to form an αboryl carbanion, deprotonation, and alkoxide addition to form an "-ate" complex. Addition of 4trifluoromethylbenzoate to this mixture established the x-boryl carbanion as the intermediate responsible for C-C bond formation and ultimately ketone synthesis. Elucidation of the role of this intermediate leveraged additional bond-forming chemistry and enabled the one-pot synthesis of ketones with α-halogen atoms and quaternary centers with four-different carbon substituents.

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Section: Mechanistic Studiesmentioning

confidence: 99%

Ketone Synthesis from Benzyldiboronates and Esters: Leveraging α-Boryl Carbanions for Carbon–Carbon Bond Formation

Lee

Chirik

2020

J. Am. Chem. Soc.

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“…91 Interestingly, both the removal of copper residues from the crude reaction mixtures and the challenging pivaloyl directing group deprotection could efficiently be included in the process. Finally, it ought to be mentioned that interesting extensions to heterogeneous catalysis were efficiently developed by the Park, 92 Hong and Kwak, 93 and Glorius 94 groups using copper nanoparticles entrapped in aluminum oxyhydroxide (Cu/AlO(OH)), copper–zeolite frameworks or copper oxide on magnetite (CuO/Fe 3 O 4 ), respectively, thereby enabling easy recycling of the catalysts.…”

Section: Meta -Arylation Of Anilinesmentioning

confidence: 99%

Direct Arylation of C(sp2)–H Bonds in Anilines

et al. 2023

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Anilines selectively arylated at their ortho-, meta- or para- positions are useful building blocks in synthesis and have found applications in many areas. The most straightforward method for their synthesis relies on the direct arylation of a C(sp2)-H bond of anilines, an attractive strategy avoiding the prefunctionalization of the starting anilines provided that such arylations proceed with high levels of regioselectivity. Such reactions are presented and discussed, in a comprehensive manner, in this review article, with an emphasis on the regioselectivity of the processes and factors governing both the reactivity and selectivity.

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“…Similarly, the fast ISC transition also leads to a relatively short lifetime value of ≈20 ms for Czs‐ph‐3F. Thus, it indicates that when p ‐π* transition predominant in RTP achievement, incorporating p ‐units can effectively accelerate the rate‐determining ISC transition, thereby increasing triplet radiation probability and also shortening triplet lifetime [3a, 4, 12b, 13a, 15] …”

Section: Introductionmentioning

confidence: 95%

Phosphine‐Manipulated p‐π and π‐π Synergy Enables Efficient Ultralong Organic Room‐Temperature Phosphorescence

Song

Man

et al. 2023

Angewandte Chemie

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Organic room temperature phosphorescence (RTP) attracts extensive attentions, but still faces the challenge of achieving both high RTP efficiencies (ηRTP) and long lifetimes (τRTP), due to the intrinsic contradiction between triplet radiation and stabilization. In this work, we developed three carbazole‐triphenylphosphine hybrids named xCzTPP, in which phosphine groups provide nonbonding electrons and steric hindrance to modulate intermolecular p‐π and π‐π interactions. With the rational orientations and spatial positions of functional groups, para‐substituted pCzTPP achieves high ηRTP over 10 % and more than twofold increased τRTP (>600 ms), compared to ortho‐ and meta‐ isomers. Theoretical simulation and photophysical investigation indicate that the strongest intermolecular p‐π and π‐π electronic interplays of pCzTPP harmonize high transition probability of 3pπ state and triplet stability of 3ππ state, reflecting the p‐π and π‐π synergy in RTP process.

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Prenatal diagnosis of interchromosomal insertion of Y chromosome heterochromatin in a family

Cited by 4 publications

References 14 publications

Ketone Synthesis from Benzyldiboronates and Esters: Leveraging α-Boryl Carbanions for Carbon–Carbon Bond Formation

Ketone Synthesis from Benzyldiboronates and Esters: Leveraging α-Boryl Carbanions for Carbon–Carbon Bond Formation

Direct Arylation of C(sp2)–H Bonds in Anilines

Phosphine‐Manipulated p‐π and π‐π Synergy Enables Efficient Ultralong Organic Room‐Temperature Phosphorescence

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