Prenatal Exposure to Air Pollution and Newborn Blood Pressure

Lenie, van Rossem; Melley, Steven; Sheryl, Rifas-Shiman; Zanobetti, Antonella; A., Coull Brent; D., Schwartz Joel; A., Mittleman Murray; Oken, Emily; Matthew, G. Douglas; Petros, Koutrakis; R., Gold Diane

doi:10.1289/isee.2013.p-2-05-26

Cited by 5 publications

(7 citation statements)

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“…Because of the known importance of the third trimester in fetal development, and in the interest of retaining a large number of subjects, we limited analysis to the 412 mothers for whom we had daily PM 2.5 measurements at their residential addresses for the last 90 days prior to delivery. While analyzing the entirety of gestation would be preferable, exploring the last trimester of pregnancy does not preclude us from finding biologically meaningful windows of susceptibility; previous studies have found associations between prenatal air pollution in the third trimester and newborn health outcomes such as systolic blood pressure (van Rossem et al, 2015) and fetal growth (Lamichhane et al, 2018).…”

Section: Pm 25 Datamentioning

confidence: 99%

Function-on-Function Regression for the Identification of Epigenetic Regions Exhibiting Windows of Susceptibility to Environmental Exposures

Zemplenyi¹,

Meyer²,

Cárdenas³

et al. 2019

Preprint

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The ability to identify time periods when individuals are most susceptible to exposures, as well as the biological mechanisms through which these exposures act, is of great public health interest. Growing evidence supports an association between prenatal exposure to air pollution and epigenetic marks, such as DNA methylation, but the timing and gene-specific effects of these epigenetic changes are not well understood.Here, we present the first study that aims to identify prenatal windows of susceptibility to air pollution exposures in cord blood DNA methylation. In particular, we propose a function-on-function regression model that leverages data from nearby DNA methylation probes to identify epigenetic regions that exhibit windows of susceptibility to ambient particulate matter less than 2.5 microns (PM 2.5 ). By incorporating the covariance structure among both the multivariate DNA methylation outcome and the time-varying exposure under study, this framework yields greater power to detect windows of susceptibility and greater control of false discoveries than methods that model probes independently. We compare our method to a distributed lag model approach that models DNA methylation in a probe-by-probe manner, both in simulation and by application to motivating data from the Project Viva birth cohort. In two epigenetic regions selected based on prior studies of air pollution effects on epigenome-wide methylation, we identify windows of susceptibility to PM 2.5 exposure near the beginning and middle of the third trimester of pregnancy.

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Section: Pm 25 Datamentioning

confidence: 99%

Function-on-Function Regression for the Identification of Epigenetic Regions Exhibiting Windows of Susceptibility to Environmental Exposures

Zemplenyi¹,

Meyer²,

Cárdenas³

et al. 2019

Preprint

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“…Children are the most vulnerable group to the hazardous effects of ambient air pollution which begin even before the child is born (Salvi, 2007). Van Rossem et al (2015) performed a study on the impact of pollution on newborn systolic blood pressure (SBP) due to antenatal exposure to air pollution. The study concluded that exposures O3 in the later stage of pregnancy were negatively associated with SBP whereas particulate matters and BC were positively associated with newborn SBP.…”

Section: Introductionmentioning

confidence: 99%

Modeling the Impact of Rain on Population Exposed to Air Pollution

Sharma

Kumari

2020

International Journal of Nonlinear Sciences and Numerical Simulation

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Environmental pollution, comprising of air, water and soil have emerged as a serious problem in past two decades. The air pollution is caused by contamination of air due to various natural and anthropogenic activities. The growing air pollution has diverse adverse effects on human health and other living species. However, a significant reduction in the concentration of air pollutants has been observed during the rainy season. Recently, a number of studies have been performed to understand the mechanism of removal of air pollutants due to the rain. These studies have found that rain is helpful in removing many air pollutants from the environment. In this paper, we proposed a mathematical model to investigate the role of rain in removal of air pollutants and its subsequent impacts on human population.

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“…Air pollution has been demonstrated to alter DNA methylation both globally and at specific target genes. Human workplace exposure to PM 10 has been found to be associated with global hypomethylation at long interspersed nuclear element-1 and Alu repetitive DNA elements in circulating leukocytes, as well as decreased methylation at the iNOS promoter (13). A study of exposure to PM 2.5 demonstrated a similar hypomethylation of DNA in peripheral blood leukocyte DNA (14).…”

mentioning

confidence: 98%

“…Early life exposure to PM 2.5 has been increasingly recognized for its impact on newborn health. Exposure to PM 10 during pregnancy has been linked with decreased birth weight, reduced placental weight (7), and placental oxidative and nitrosative stress (8), which further suggests that particulate matter air pollution contributes to placental insufficiency and intrauterine growth restriction.…”

mentioning

confidence: 99%

“…Placental insufficiency and intrauterine growth restriction has been implicated as an important determinant of adult cardiovascular health via the fetal origins of adult disease or Barker hypothesis pathway (9). These in utero PM exposures that induce placental insufficiency may predispose offspring to increased risk of disease, and, indeed, exposure to PM 2.5 during the last trimester of pregnancy has been reported to be associated with increased newborn systolic blood pressure (10). Whereas prospective studies have not yet been carried out to determine whether the effects of maternal exposure affect the health of the offspring into adulthood, experimental studies that have used animal models raise the concern that in utero exposure to air pollution may be a strong determinant of adult health.…”

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confidence: 99%

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In utero exposure to diesel exhaust particulates is associated with an altered cardiac transcriptional response to transverse aortic constriction and altered DNA methylation

et al. 2017

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exposure to diesel exhaust air pollution has been associated with increased adult susceptibility to heart failure in mice, but the mechanisms by which this exposure promotes susceptibility to heart failure are poorly understood. To identify the potential transcriptional effects that mediate this susceptibility, we have performed RNA sequencing analysis on adult hearts from mice that were exposed to diesel exhaust and that have subsequently undergone transverse aortic constriction. We identified 3 target genes,, , and, which demonstrate dysregulation after exposure and aortic constriction. Examination of expression patterns in human heart tissues indicates a correlation between expression and heart failure. We subsequently assessed DNA methylation modifications at these candidate loci in neonatal cultured cardiac myocytes after exposure to diesel exhaust and found that the promoter for is differentially methylated. These target genes in the heart are the first genes to be identified that likely play an important role in mediating adult sensitivity to heart failure. We have also shown a change in DNA methylation within cardiomyocytes as a result of exposure to diesel exhaust.-Goodson, J. M., Weldy, C. S., MacDonald, J. W., Liu, Y., Bammler, T. K., Chien, W.-M., Chin, M. T. exposure to diesel exhaust particulates is associated with an altered cardiac transcriptional response to transverse aortic constriction and altered DNA methylation.

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Prenatal Exposure to Air Pollution and Newborn Blood Pressure

Cited by 5 publications

References 0 publications

Function-on-Function Regression for the Identification of Epigenetic Regions Exhibiting Windows of Susceptibility to Environmental Exposures

Function-on-Function Regression for the Identification of Epigenetic Regions Exhibiting Windows of Susceptibility to Environmental Exposures

Modeling the Impact of Rain on Population Exposed to Air Pollution

In utero exposure to diesel exhaust particulates is associated with an altered cardiac transcriptional response to transverse aortic constriction and altered DNA methylation

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