Prenatal exposure to glufosinate ammonium disturbs gut microbiome and induces behavioral abnormalities in mice

Dong, Tianyu; Guan, Quanquan; Hu, Wu; Zhang, Mingzhi; Zhang, Yuqing; Chen, Minjian; Wang, Xinru; Xia, Yankai

doi:10.1016/j.jhazmat.2020.122152

Cited by 31 publications

(33 citation statements)

References 39 publications

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“…That is, most of the studies included in the present review are concerned with OP exposure (13 out of 16, 81.3%). Of the remaining articles, two used Glufosinate ammonium (GLA) (12.5%) [ 43 , 44 ], and one exposed their animals to the synthetic Pyrethroid cypermethrin (CYP) (6.3%) [ 45 ]. From all of these studies, only one [ 42 ] did not administer the pesticide during development; thus, most of the studies included in this systematic review present good examples of developmental neurotoxicity (15 out of 16, 93.8%).…”

Section: Resultsmentioning

confidence: 99%

“…Concerning the quality of the preclinical studies, three out of the 16 were labeled as H (18.8%) [ 30 , 37 , 38 ], 10 as MH (62.5%) [ 31 , 32 , 33 , 34 , 35 , 36 , 40 , 43 , 44 , 45 ], and the remaining three as ML-quality (18.8%) [ 39 , 41 , 42 ]. In a similar vein, 37 out of 45 human studies were classified as VH (82.2%) [ 46 , 48 , 49 , 50 , 51 , 52 , 53 , 56 , 57 , 58 , 59 , 61 , 63 , 64 , 65 , 66 , 67 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 80 , 81 , 82 , 83 , 84 , 85 , 87 , 88 , 89 , 90 , 91 ], 7 as H (15.6%) [ 47 , …”

Section: Resultsmentioning

confidence: 99%

“…All three studies that used xenobiotic compounds other than OPs were labeled as MH-quality [ 43 , 44 , 45 ]. Dong et al [ 44 ] exposed female mice to GLA from 8 weeks before mating to delivery, whilst Laugeray et al 43], and Laugeray et al [ 45 ] used GLA (the former) and CYP (the latter) in a continuous gestational-postnatal exposure protocol in mice models.…”

Section: Resultsmentioning

confidence: 99%

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Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models

Biosca-Brull

Pérez-Fernández

Mora

et al. 2021

IJERPH

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Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models

Biosca-Brull

Pérez-Fernández

Mora

et al. 2021

IJERPH

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show abstract

“…which could be the cause of the behavioral abnormalities. 41 Another study reported no effect on body-weight gains in the parent or offspring, nor on the survival of the offspring. 38 Another factor contributing to the safety of glufosinate on animal systems is the rapid rate of metabolic degradation of the active ingredient, with most of the product and/or its metabolites excreted through urine and feces.…”

Section: Glufosinate Toxicologymentioning

confidence: 98%

“…Exposing mice to glufosinate prenatally reduced locomotor activity, impaired memory formation and autism‐like behaviors. This was associated to a significant alteration in gut microbiome, which could be the cause of the behavioral abnormalities 41 . Another study reported no effect on body‐weight gains in the parent or offspring, nor on the survival of the offspring 38 .…”

Section: Glufosinate Toxicologymentioning

confidence: 99%

Glufosinate‐ammonium: a review of the current state of knowledge

Takano

Dayan

2020

Pest Management Science

166

158

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Glufosinate is a key herbicide to manage glyphosate-resistant weeds mainly because it is a broad-spectrum herbicide, and transgenic glufosinate-resistant crops are available. Although glufosinate use has increased exponentially over the past decade, the treated area with this herbicide is far less than that with glyphosate. This is because glufosinate often provides inconsistent performance in the field, which is attributed to several factors including environmental conditions, application technology, and weed species. Glufosinate is also highly hydrophilic and does not translocate well in plants, generally providing poor control of grasses and perennial species. In the soil, glufosinate is rapidly degraded by microorganisms, leaving no residual activity. While there have been concerns regarding glufosinate toxicology, its proper use can be considered safe. Glufosinate is a fast-acting herbicide that was first discovered as a natural product, and is the only herbicide presently targeting glutamine synthetase. The mode of action of glufosinate has been controversial, and the causes for the rapid phytotoxicity have often been attributed to ammonia accumulation. Recent studies indicate that the contact activity of glufosinate results from the accumulation of reactive oxygen species and subsequent lipid peroxidation. Glufosinate disrupts both photorespiration and the light reactions of photosynthesis, leading to photoreduction of molecular oxygen, which generates reactive oxygen species. The new understanding of the mode of action provided new ideas to improve the herbicidal activity of glufosinate. Finally, a very few weed species have evolved glufosinate resistance in the field, and the resistance mechanisms are generally not well understood requiring further investigation.

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Chronic oral exposure to pesticides and their consequences on metabolic regulation: role of the microbiota

et al. 2021

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Pesticides have long been used in agriculture and household treatments. Pesticide residues can be found in biological samples for both the agriculture workers through direct exposure but also to the general population by indirect exposure. There is also evidence of pesticide contamination in utero and trans-generational impacts.Whilst acute exposure to pesticides has long been associated with endocrine perturbations, chronic exposure with low doses also increases the prevalence of metabolic disorders such as obesity or type 2 diabetes. Dysmetabolism is a low-grade inflammation disorder and as such the microbiota plays a role in its etiology. It is therefore important to fully understand the role of microbiota on the genesis of subsequent health effects. The digestive tract and mostly microbiota are the first organs of contact after oral exposure. The objective of this review is thus to better understand mechanisms that link pesticide exposure, dysmetabolism and microbiota.One of the key outcomes on the microbiota is the reduced Bacteroidetes and increased Firmicutes phyla, reflecting both pesticide exposure and risk factors of dysmetabolism. Other bacterial genders and metabolic activities are also involved. As for most pathologies impacting microbiota (including inflammatory disorders), the role of prebiotics can be suggested as a prevention strategy and some preliminary evidence reinforce this axis.

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Prenatal exposure to glufosinate ammonium disturbs gut microbiome and induces behavioral abnormalities in mice

Cited by 31 publications

References 39 publications

Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models

Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models

Glufosinate‐ammonium: a review of the current state of knowledge

Chronic oral exposure to pesticides and their consequences on metabolic regulation: role of the microbiota

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