Prenatal exposure to organic pollutants in northwestern Spain using non-invasive matrices (placenta and meconium)

Fernández-Cruz, Tania; Álvarez-Silvares, Esther; Domínguez-Vigo, Paula; Simal‐Gándara, Jesús; Martínez-Carballo, Elena

doi:10.1016/j.scitotenv.2020.138341

Cited by 35 publications

(23 citation statements)

References 42 publications

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“…The most prominent PBDEs measured in the present study was BDE-209 (contributing 28.0 % to ΣPBDEs). This congener profile was consistent with several studies ( 3 , 5 , 28 , 33 – 35 , 39 ), while inconsistent with others in which BDE-47 was a major congener in placenta samples ( 4 , 25 , 31 , 32 , 37 , 38 , 40 , 41 ). Only one study in Denmark reported BDE-153 (33.6%) as the most abundant congener in human placenta ( 36 ).…”

Section: Discussionsupporting

confidence: 84%

“…The median PBDEs levels in the current study (10.08 ng/g lw) were lower than that found in placenta from the USA (ranging from 19.1 to 33 ng/g lw) (4,31,32), and Korea (11.7 ng/g lw) ( 5), but higher than that in Uganda (7.76 ng/g lw) (33), and European samples (ranging from 1.04 to 2.31 ng/g lw) (3,25,(34)(35)(36)(37). In China, only five studies have reported PBDEs levels in placenta tissue samples (28,(38)(39)(40)(41).…”

Section: Discussioncontrasting

confidence: 69%

“…The placenta sits at the interface between the maternal and fetal vascular beds where it mediates nutrient and waste exchange and can act as a protective barrier against toxins and environmental contaminants ( 24 ). The fetus is exposed to toxic contaminants only via the placenta, which is regarded as a medium that reflects the simultaneous exposure status to persistent organic pollutants of mothers and their fetuses ( 5 , 25 ). Measurement of PBDEs in human placental tissues is essential to explore their potential fetal exposure.…”

Section: Introductionmentioning

confidence: 99%

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Associations Between Polybrominated Diphenyl Ethers Concentrations in Human Placenta and Small for Gestational Age in Southwest China

Liu

Xie

Tian

et al. 2022

Front. Public Health

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BackgroundPrenatal exposures to polybrominated diphenyl ethers (PBDEs) may affect fetal growth. Small for gestational age (SGA) is a measure based on birth weight and gestational age at birth and represents a good indicator of fetal growth but it has been used only in a small number of studies. The present study aimed to examine the associations between PBDEs exposure and the risk of SGA among participants from a birth cohort in Southwest China.MethodsThe concentrations of eight common PBDE congeners (BDE-28, BDE47, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183, and BDE-209) in 996 human placental samples collected between May to October 2020 were determined. A questionnaire survey was administered regarding maternal characteristics. The outcome data of the newborns were obtained from the medical record. The Mann–Whitney U test and binomial logistic regression analysis were used to assess associations between PBDEs concentrations (as a continuous or categorical variable) and SGA.ResultsAll PBDE congeners were detected in more than 73% of samples. The median concentrations of ΣPBDEs were 10.08 ng/g lipid weight (lw). BDE-209 was the most abundant PBDE congener, contributed 28% to ΣPBDEs. There were 114 (11.4%) SGA infants. The levels of BDE-99, BDE-100, BDE-209, and the total levels of ΣPBDEs in the SGA group were significantly higher than those in the controls. When classifying the PBDEs concentrations as two categories: low and high, high level of ΣPBDEs was associated with increased risk of SGA [odds ratio (OR): 2.203, 95% confidence interval (CI): 1.453–3.340] after adjusting for potential covariates. The association remained significant when stratifying the data by gender of the newborn (OR: 2.572, 95% CI: 1.337–4.947 for boys; OR: 2.385, 95% CI: 1.315–4.325 for girls).ConclusionThe present study adds to the literature by using placenta to measure PBDEs exposure during pregnancy, and provides evidence that prenatal exposure to PBDEs may be associated with the risk of SGA, at least at the levels of exposure in our population.

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Section: Discussionsupporting

confidence: 84%

Section: Discussioncontrasting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Associations Between Polybrominated Diphenyl Ethers Concentrations in Human Placenta and Small for Gestational Age in Southwest China

Liu

Xie

Tian

et al. 2022

Front. Public Health

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“…It is expected that placental tissue measurements may improve detection rates due to the higher concentrations relative to fetal tissues and a large amount of available tissue at delivery. In support of the utility of placental pyrethroid measurements, a recent study demonstrated that within the same cohort, pyrethroids were detectable in 90% of placental samples as compared to only 26% of meconium samples ( Fernández-Cruz et al, 2020 ).…”

Section: Resultsmentioning

confidence: 91%

Maternal and fetal tissue distribution of α-cypermethrin and permethrin in pregnant CD-1 mice

Elser

Simonsen

Lehmler

et al. 2022

Environmental Advances

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“…These organic molecules are stored in adipose tissue and have very long half-lives ranging from months to several years. Different authors have demonstrated the ability of OPS to deposit in the placenta and pass to the fetus [4,10,11].…”

Section: Introductionmentioning

confidence: 99%

Determination of organic pollutants in meconium and its relationship with fetal growth. Case control study in Northwestern Spain

Álvarez-Silvares

Rubio-Cid

González-Gómez

et al. 2021

Journal of Perinatal Medicine

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Objectives Antenatal exposure to organic pollutants is a leading public health problem. Meconium is a unique matrix to perform prenatal studies because it enables us to retrospectively evaluate fetal exposure accumulated during the second and third trimester. The aim of the present study was to evaluate associations between organic pollutant levels in meconium and birth weight in NW Spain. Methods In this study, we quantify the concentrations of 50 organic pollutants together with the total values of the most important chemical groups in meconium using gas chromatography coupled to tandem mass spectrometry. Results Organochlorine pesticides, polychlorinated biphenyls and polybrominated diphenyl ethers were detected with the highest levels in meconium from small for gestational age newborns. It was estimated that several congeners were statistically significant (p<0.05). However, organophosphorus pesticides attained higher concentrations in newborns with an appropriate weight. Conclusions The occurrence of transplacental transfer can be confirmed. Prenatal exposure to organic pollutants was associated with a decrease in birth weight and, therefore, organic pollutants could have an impact on fetal growth. Nevertheless, these results need validation in larger sample sized studies.

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Prenatal exposure to organic pollutants in northwestern Spain using non-invasive matrices (placenta and meconium)

Cited by 35 publications

References 42 publications

Associations Between Polybrominated Diphenyl Ethers Concentrations in Human Placenta and Small for Gestational Age in Southwest China

Associations Between Polybrominated Diphenyl Ethers Concentrations in Human Placenta and Small for Gestational Age in Southwest China

Maternal and fetal tissue distribution of α-cypermethrin and permethrin in pregnant CD-1 mice

Determination of organic pollutants in meconium and its relationship with fetal growth. Case control study in Northwestern Spain

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