Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort

Donahue, Sara; Rifas‐Shiman, Sheryl L.; Gold, Diane R.; Jouni, Zeina E.; Gillman, Matthew W.; Oken, Emily

doi:10.3945/ajcn.110.005801

Cited by 211 publications

(240 citation statements)

References 39 publications

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“…New dietary recommendations take into account the insufficient intake of ω3 PUFAs and the excess of ω6 PUFAs, which correlate with overweight/obesity (3)(4)(5). Indeed, high ω6/ω3 ratios are positively associated with adiposity of infants at 6 months, 3 and 4 years of age (6)(7)(8), and ARA intake correlates positively with the body mass index (BMI) and the associated metabolic syndrome (9)(10)(11)(12)(13). In fact, diets exhibiting a high ω6/ω3 ratio result in a higher ARA bioavailability for the synthesis of ω6 derived oxylipins due to an insufficient compensatory effect of EPA and DHA (14).…”

Section: Introductionmentioning

confidence: 99%

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

Ghandour

Colson

Giroud

et al. 2018

Journal of Lipid Research

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Section: Introductionmentioning

confidence: 99%

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

Ghandour

Colson

Giroud

et al. 2018

Journal of Lipid Research

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“…Controversial results have been obtained. High ω6/ω3 ratio determined in umbilical cord blood phospholipids was associated with a high subscapular skin-fold thickness at 3 years of age taken as an index of child adiposity (Donahue et al, 2011). In contrast, supplementation with EPA/DHA and recommendation to lower arachidonic acid intake during pregnancy and lactation did not show any effect on infant fat mass and fat distribution during the first year of life (Hauner et al, 2012).…”

Section: Arachidonic Acid Prostacyclin Pgeand White Adipogenesismentioning

confidence: 89%

Disequilibrium of polyunsaturated fatty acids status and its dual effect in modulating adipose tissue development and functions

Pisani

Amri

Ailhaud

2015

OCL

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-White adipocytes are storing energy under the form of triglycerides whereas brown adipocytes dissipate energy from triglycerides by producing heat. In rodents and possibly in humans both types of fat cells participate in the total energy balance. From a quantitative view point, a positive energy balance (energy intake > energy expenditure) is commonly regarded as a major factor contributing to obesity. Recent studies demonstrate that by altering rates of adipocyte differentiation and proliferation, differences in fatty acid composition of dietary fats may also contribute to adipose tissue development, in particular with respect to the relative intake of ω6 to ω3 poly-unsaturated fatty acids (PUFAs). The ω6/ω3 ratio determines the availability of ω6-arachidonic acid (ARA) within adipose tissue and thus the level of various prostaglandins derived from the cyclooxygenase-mediated pathway. We had shown earlier that prostacyclin (Prostaglandin I2) stimulates fat cell differentiation and this effect could be reversed by ω3-PUFA supplementation. Moreover, we had assessed that under conditions of genome stability a Western-like fat diet rich in ω6-PUFA was sufficient to induce a gradual fat mass enhancement across generations. Recently, we have characterized a second effect of some ARA metabolites (prostaglandins E2 and F2α) which appear to inhibit the formation of brown adipocytes within white adipose tissue. Altogether, our results demonstrate that, in addition to favoring white adipose tissue formation, dietary excess of ω6-PUFA prevents the "browning" process to take place in white adipose tissue depots, and strongly suggest a favorable role of ω3-PUFA supplementation in preventing both processes.Keywords: White adipocyte / brite/brown adipocyte / arachidonic acid / prostaglandin / obesity Résumé -Double effet d'un déséquilibre du statut en acides gras polyinsaturés sur le développement et les fonctions du tissu adipeux. Les adipocytes blancs stockent l'énergie sous forme de triglycérides alors que les adipocytes bruns dissipent l'énergie issue de ces triglycérides en produisant de la chaleur. Chez les rongeurs, et certainement chez les humains, ces deux types d'adipocytes participent à l'équilibre énergétique global. D'un point de vue quantitatif, une balance énergétique positive (apports énergétiques > dépenses énergétiques) est généralement considérée comme un facteur important contribuant à l'obésité. Des études récentes démontrent que des différences de composition en acides gras des graisses alimentaires en particulier le ratio entre les acides gras polyinsaturés ω6 et ω3, contribuent au déve-loppement du tissu adipeux en altérant les niveaux de prolifération et de différenciation des adipocytes. Le ratio ω6/ω3 détermine la disponibilité de l'acide arachidonique ω6 (ARA) au sein du tissu adipeux et ainsi le niveau des différentes prostaglandines dérivées de la voie métabolique contrôlée par les cyclooxygénases. Nous avons précédemment montré que la prostacycline (Prostaglandin I2) stimule la différen...

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“…По данным Р. Catalano и соавт., избыточный вес и ожирение у женщины до наступления беременности являются достоверно сильным фактором риска развития ожирения и метаболических нарушений у потомства [14]. Увеличение частоты случаев ожирения у беременных женщин сопровождается ростом числа случаев макросо-мии плода и новорожденного и ранним (в первые полгода жизни) развитием избыточной массы тела у младенца [15]. Ожирение у женщины до и во время беременно-сти -существенный фактор риска развития патологии у потомства [16].…”

Section: причины развития ожиренияunclassified

Obesity in Children: New Prevention Concepts and Approaches. Literature Review

Нетребенко¹,

Ukraintsev²,

Мельникова³

2017

Vopr. sovr. pediatr.

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Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort

Abstract: An enhanced maternal-fetal n-3 PUFA status was associated with lower childhood adiposity.

Cited by 211 publications

References 39 publications

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

Impact of dietary ω3 polyunsaturated fatty acid supplementation on brown and brite adipocyte function

Disequilibrium of polyunsaturated fatty acids status and its dual effect in modulating adipose tissue development and functions

Obesity in Children: New Prevention Concepts and Approaches. Literature Review

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