Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children

Grohs, Melody N.; Reynolds, Jess E.; Liu, Jiaying; Martin, Jonathan W.; Pollock, Tyler; Lebel, Catherine; Dewey, Deborah

doi:10.1186/s12940-019-0528-9

Cited by 60 publications

(45 citation statements)

References 99 publications

(101 reference statements)

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“…The findings by Grohs at al. reinforce that the prenatal period is the most critical window of BPA exposure for behavior, in line with previous studies (Supplemental Table 2), suggesting an organizational effect in the fetal brain [1]. Although prenatal BPA exposure was significantly associated with increased internalizing problems in the APrON cohort, an imprecise but potential association towards externalizing problems was also apparent and cannot be ruled out based on the small sample size of the population studied [1].…”

Section: Emerging Patterns In a Growing Literaturesupporting

confidence: 89%

“…anxiety and depression symptoms). Postnatal urinary BPA concentrations were not associated with either brain microstructure or behavior [1].…”

Section: A Key Contribution To a Hot Topicmentioning

confidence: 75%

“…In humans, prenatal associations were mainly -but not uniquely-reported among boys (Table 1). Grohs et al however, did not find sex-specific associations with either children's brain structure or behavior [1]. Nonetheless, this possibility cannot be ruled out based on the small sample size analyzed, likely underpowered compared to previous mother-child cohorts.…”

Section: Emerging Patterns In a Growing Literaturementioning

confidence: 87%

“…In a recent issue of Environmental Health, Grohs and colleagues [1] examined whether prenatal BPA exposure was associated with offspring's brain microstructure and behavior in a sub-cohort of 98 mother-child pairs from the Canadian Alberta Pregnancy Outcomes and Nutrition (APrON) study. Healthy children, free of any neurodevelopmental disorder, underwent a diffusion magnetic resonance imaging (MRI) scan at 2-5 years of age to assess white matter microstructure in major brain regions.…”

Section: A Key Contribution To a Hot Topicmentioning

confidence: 99%

“…For the first time, Grohs and colleagues found that higher maternal urinary BPA concentrations, at around 17 weeks of gestation, were associated with a less developed white matter in the splenium (subregion of corpus callosum) and in the right inferior longitudinal fasciculus (tract connecting the anterior temporal and occipital lobes) [1]. Moreover, white matter differences in the splenium mediated the association between prenatal BPA exposure and children's internalizing problems (e.g.…”

Section: A Key Contribution To a Hot Topicmentioning

confidence: 99%

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Bisphenol A shapes children’s brain and behavior: towards an integrated neurotoxicity assessment including human data

Mustieles

Fernández

2020

Environ Health

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Concerns about the effects of bisphenol A (BPA) on human brain and behavior are not novel; however, Grohs and colleagues have contributed groundbreaking data on this topic in a recent issue of Environmental Health. For the first time, associations were reported between prenatal BPA exposure and differences in children's brain microstructure, which appeared to mediate the association between this exposure and children's behavioral symptoms. Findings in numerous previous mother-child cohorts have pointed in a similar worrying direction, linking higher BPA exposure during pregnancy to more behavioral problems throughout childhood as assessed by neuropsychological questionnaires. Notwithstanding, this body of work has not been adequately considered in risk assessment. From a toxicological perspective, results are now available from the CLARITY-BPA consortium, designed to reconcile academic and regulatory toxicology findings. In fact, the brain has consistently emerged as one of the most sensitive organs disrupted by BPA, even at doses below those considered safe by regulatory agencies such as the European Food Safety Authority (EFSA). In this Commentary, we contextualize the results of Grohs et al. within the setting of previous epidemiologic and CLARITY-BPA data and express our disquiet about the "all-or-nothing" criterion adopted to select human data in a recent EFSA report on the appraisal methodology for their upcoming BPA risk assessment. We discuss the most relevant human studies, identify emerging patterns, and highlight the need for adequate assessment and interpretation of the increasing epidemiologic literature in this field in order to support decision-making. With the aim of avoiding a myopic or biased selection of a few studies in traditional risk assessment procedures, we propose a future reevaluation of BPA focused on neurotoxicity and based on a systematic and comprehensive integration of available mechanistic, animal, and human data. Taken together, the experimental and epidemiologic evidence converge in the same direction: BPA is a probable developmental neurotoxicant at low doses. Accordingly, the precautionary principle should be followed, progressively implementing stringent preventive policies worldwide, including the banning of BPA in food contact materials and thermal receipts, with a focus on the utilization of safer substitutes.

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Section: Emerging Patterns In a Growing Literaturesupporting

confidence: 89%

“…anxiety and depression symptoms). Postnatal urinary BPA concentrations were not associated with either brain microstructure or behavior [1].…”

Section: A Key Contribution To a Hot Topicmentioning

confidence: 75%

Section: Emerging Patterns In a Growing Literaturementioning

confidence: 87%

Section: A Key Contribution To a Hot Topicmentioning

confidence: 99%

Section: A Key Contribution To a Hot Topicmentioning

confidence: 99%

See 3 more Smart Citations

Bisphenol A shapes children’s brain and behavior: towards an integrated neurotoxicity assessment including human data

Mustieles

Fernández

2020

Environ Health

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Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY‐BPA

Howdeshell,

Beverly,

Blain

et al. 2023

Birth Defects Research

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BackgroundThe Consortium Linking Academic and Regulatory Insights on Bisphenol A Toxicity (CLARITY‐BPA) was a collaborative research effort to better link academic research with governmental guideline studies. This review explores the secondary goal of CLARITY‐BPA: to identify endpoints or technologies from CLARITY‐BPA and prior/concurrent literature from these laboratories that may enhance the capacity of rodent toxicity studies to detect endocrine disrupting chemicals (EDCs).MethodsA systematic literature search was conducted with search terms for BPA and the CLARITY‐BPA participants. Relevant studies employed a laboratory rodent model and reported results on 1 of the 10 organs/organ systems evaluated in CLARITY‐BPA (brain and behavior, cardiac, immune, mammary gland, ovary, penile function, prostate gland and urethra, testis and epididymis, thyroid hormone and metabolism, and uterus). Study design and findings were summarized, and a risk‐of‐bias assessment was conducted.ResultsSeveral endpoints and methods were identified as potentially helpful to detect effects of EDCs. For example, molecular and quantitative morphological approaches were sensitive in detecting alterations in early postnatal development of the brain, ovary, and mammary glands. Hormone challenge studies mimicking human aging reported increased susceptibility of the prostate to disease following developmental BPA exposure. Statistical analyses for nonmonotonic dose responses, and computational approaches assessing multiple treatment‐related outcomes concurrently in linked hormone‐sensitive organ systems, reported effects at low BPA doses.ConclusionsThis review provided an opportunity to evaluate the unique insights provided by nontraditional assessments in CLARITY‐BPA to identify technologies and endpoints to enhance detection of EDCs in future studies.

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Endocrine-Disrupting Chemicals and the Offsprings: Prenatal Exposure

Solerte,

Cosmi

2023

Environment Impact on Reproductive Health

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Over the last 10 decades, the changes in normal environmental conditions, directly or indirectly connected to the presence of several chemical substances released in various ways and means, for many territories, throughout the planet, have become extremely evident, as well as the relative consequences assessed, which involve numerous international working groups. Starting from territorial pollution and known environmental disasters, the World Health Organization, Food and Drug Administration, European Food Safety Authority, European Commission, other international regulatory agencies, scientific societies, and research groups had proposed, through milestone epochs, the methods of study and monitoring of environmentally harmful molecules capable of interfering with the endocrine system, in wildlife, laboratory animals, and humans. Moreover, attention was focused on endocrine functions related to reproductive health and on mechanisms of interaction, during gestation, between fetus, mother, and placenta, in order to bridge the gap of the lack of knowledge in this global theme.

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Prenatal maternal and childhood bisphenol a exposure and brain structure and behavior of young children

Cited by 60 publications

References 99 publications

Bisphenol A shapes children’s brain and behavior: towards an integrated neurotoxicity assessment including human data

Bisphenol A shapes children’s brain and behavior: towards an integrated neurotoxicity assessment including human data

Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY‐BPA

Endocrine-Disrupting Chemicals and the Offsprings: Prenatal Exposure

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