Prenatal morphine exposure differentially alters learning and memory in male and female rats

Šlamberová, Romana; Schindler, Cheryl J.; Pometlová, Marie; Urkuti, Claudia; Purow-Sokol, Jennifer A; Vathy, Ilona

doi:10.1016/s0031-9384(01)00469-3

Cited by 66 publications

(30 citation statements)

References 42 publications

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“…This is particularly important given that there is substantial evidence that males may be more vulnerable to the impact of early-life stressors such as maternal separation [50][51][52][53]. In addition, the observations of Slamberova et al [43] and Nasiraei-Moghadam et al [44] in rodents suggest that sex hormones during puberty may play a role in the sexdependent risk of cognitive and behavioural deficits caused by prenatal opiate exposure.…”

Section: (A) Prenatal Exposure To Opiatesmentioning

confidence: 99%

An examination of sex differences in the effects of early-life opiate and alcohol exposure

Terasaki¹,

Gomez²,

Schwarz³

2016

Phil. Trans. R. Soc. B

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One contribution of 16 to a theme issue 'Multifaceted origins of sex differences in the brain'. Early-life exposure to drugs and alcohol is one of the most preventable causes of developmental, behavioural and learning disorders in children. Thus a significant amount of basic, animal and human research has focused on understanding the behavioural consequences and the associated neural effects of exposure to drugs and alcohol during early brain development. Despite this, much of the previous research that has been done on this topic has used predominantly male subjects or rodents. While many of the findings from these male-specific studies may ultimately apply to females, the purpose of this review is to highlight the research that has also examined sex as a factor and found striking differences between the sexes in their response to early-life opiate and alcohol exposure. Finally, we will also provide a framework for scientists interested in examining sex as a factor in future experiments that specifically examine the consequences of early-life drug and alcohol exposure.

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Section: (A) Prenatal Exposure To Opiatesmentioning

confidence: 99%

An examination of sex differences in the effects of early-life opiate and alcohol exposure

Terasaki¹,

Gomez²,

Schwarz³

2016

Phil. Trans. R. Soc. B

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“…There was an interaction between gender and treatment in the case of struggling behavior, as the male rats were more vulnerable (E; p = 0.05). demonstrated that prenatal morphine exposure differentially altered the performance of adult male and female rats on tasks requiring learning and spatial memory (Slamberova et al, 2001a). Another group reported disturbance in a passive avoidance retention task in females after intrauterine morphine treatment (Degos et al, 2012).…”

Section: Animal Studiesmentioning

confidence: 99%

Behavioral effects of perinatal opioid exposure

2014

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“…Morphine administered in mid to late gestation increased the latency to a complete a non-delay version of the radial arm maze (Slamberová et al, 2001). Sex specific changes in the hippocampus in mu-opioid receptors and endogenous opioids were suggested as mechanisms for the poorer learning (Schindler et al, 2004;Slamberová et al, 2003).…”

Section: Introductionmentioning

confidence: 96%

Prenatal opiate exposure impairs radial arm maze performance and reduces levels of BDNF precursor following training

2008

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Prenatal exposure to opiates, which is invariably followed by postnatal withdrawal, can affect cognitive performance. To further characterize these effects, we examined radial 8-arm maze performance and expression of brain derived neurotrophic factor (BDNF) in male rats prenatally exposed to the opiate l-α-acetylmethadol (LAAM). Female rats received 1.0 mg/kg/day LAAM or water via daily oral gavage for 28 days prior to breeding, during breeding, and throughout pregnancy. Pups were fostered to non-treated lactating dams at birth and underwent neonatal opiate withdrawal. At 5-6 months, prenatal water-and LAAM-exposed males (n=6 each; non-littermates) received radial arm maze training consisting of ten trials a day for five days and three retention trials on day six. Rats prenatally exposed to LAAM had poorer maze performance, decreased percent correct responding and more reference and working memory errors than prenatal water-treated controls. However, they were able to acquire the task by the end of training. There were no differences between the groups on retention 24 hr after testing. Following retention testing, hippocampi were removed and protein extracted from cytosol and synaptic fractions. Western blots were used to measure levels of mature and precursor BDNF protein, as well as the BDNF receptor TrkB. BDNF precursor protein was significantly decreased in the synaptic fraction of trained prenatal LAAM-treated rats compared to prenatal water-treated trained controls. No effects were found for the full-length or truncated TrkB receptor. In untrained rats, prenatal treatment did not affect any of the measures. These data suggest that prenatal opiate exposure and/or postnatal withdrawal compromise expression of proteins involved in the neural plasticity underlying learning.

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Prenatal morphine exposure differentially alters learning and memory in male and female rats

Cited by 66 publications

References 42 publications

An examination of sex differences in the effects of early-life opiate and alcohol exposure

An examination of sex differences in the effects of early-life opiate and alcohol exposure

Behavioral effects of perinatal opioid exposure

Prenatal opiate exposure impairs radial arm maze performance and reduces levels of BDNF precursor following training

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