Prenatal PM2.5 exposure and behavioral development in children from Mexico City

McGuinn, Laura A.; Bellinger, David C.; Colicino, Elena; Coull, Brent A.; Just, Allan C.; Kloog, Itai; Osorio-Valencia, Erika; Schnaas, Lourdes; Wright, Rosalind J.; Téllez‐Rojo, Martha María; Wright, Robert O.; Horton, Megan

doi:10.1016/j.neuro.2020.09.036

Cited by 46 publications

(40 citation statements)

References 49 publications

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“…The results did not confirm previously reported results, which find a developmental delay in fine motor abilities [ 18 ] and behavioral functioning [ 19 ]. Hence, further studies are needed to assess the multiple developmental domains to better understand the relationship between exposure to air pollution and different developmental domains.…”

Section: Discussioncontrasting

confidence: 99%

“…A large study among six European countries (9482 children aged 1–6 years) found an association between NO 2 exposures during pregnancy and reduced psychomotor development [ 3 ]. Studies involving homogeneous populations [ 16 , 17 , 18 , 19 ] or longitudinal evaluations [ 20 , 21 , 22 ] confirmed the significant impact of prenatal exposure to air pollution on behavioral and cognitive functioning in children. In particular, studies comparing results between prenatal and postnatal exposure confirmed that pregnancy is a target temporal window [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 94%

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Association between Exposure to Particulate Matter during Pregnancy and Multidimensional Development in School-Age Children: A Cross-Sectional Study in Italy

Girardi

Lanfranchi

Mastromatteo

et al. 2021

IJERPH

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Air pollutants can potentially affect the development of children. However, data on the effect of exposure to air pollution during pregnancy and developmental outcomes in school children are rare. We investigated the link between prenatal exposure to particulate matters smaller than 10 microns (PM10) and the development of school-age children in multiple domains. Cross-sectional data were collected in Italy between 2013 and 2014. Children aged between 5 and 8 years (n = 1187) were assessed on cognitive, communication, socio-emotional, adaptive, and motor developmental domains using the Developmental Profile 3 questionnaire. The monthly average concentration of PM10 during the entire fetal period was linked to the municipality of residence of the children. The increase in the prenatal PM10 was associated with a decrease in the cognitive score during the second (+13.2 µg/m3 PM10 increase: −0.30 points; 95%CI: −0.12–−0.48) and third trimesters of pregnancy (−0.31 points; 95%CI: −0.11–−0.50). The communicative domain was also negatively influenced by PM10 increases in the second trimester. The development of cognitive and communicative abilities of children was negatively associated with the exposure to PM10 during the period of fetal development, confirming that exposure to air pollution during pregnancy can potentially hinder the development of the brain.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Association between Exposure to Particulate Matter during Pregnancy and Multidimensional Development in School-Age Children: A Cross-Sectional Study in Italy

Girardi

Lanfranchi

Mastromatteo

et al. 2021

IJERPH

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“…Brain development is a rapid and complex process and the timing of exposure to neurotoxicants may be an important determinant of adverse impacts [ 15 , 34 , 35 ]. Our finding of consistent associations with exposure in the first trimester is similar to a recent analysis of 4 to 6-year-old children in Mexico City [ 11 ]. In that study, which assessed behavior using an earlier version of the BASC (BASC-2), a 5 µg/m 3 increase in outdoor PM 2.5 concentration during the first trimester was associated with a 1.1 unit (95% CI: -0.2, 2.4) increase in mean BSI T score and a decrease of 1.5 units (95% CI: -2.6, -0.3) in mean adaptive skills T score.…”

Section: Discussionsupporting

confidence: 91%

“…Given the speed and complexity of brain development, the impact of an exposure may depend on timing [ 11 , 15 , 16 ]. Two studies of PM exposure and behavior problems in childhood have evaluated the impacts of exposure during specific stages of pregnancy and suggested that exposures in the first and third trimesters may be most important [ 7 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Portable HEPA filter air cleaner use during pregnancy and children’s behavior problem scores: a secondary analysis of the UGAAR randomized controlled trial

et al. 2021

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Background Developmental exposure to particulate matter (PM) air pollution may impair children’s behaviors. Our objectives were to quantify the impact of reducing indoor PM using portable HEPA filter air cleaners during pregnancy on behavioral problems in children and to assess associations between indoor fine PM (PM2.5) concentrations during pregnancy and children’s behavior. Methods This is a secondary analysis of a single-blind parallel-group randomized controlled trial in which we randomly assigned 540 non-smoking pregnant women to receive 1 or 2 HEPA filter air cleaners or no air cleaners. We administered the Behavior Assessment System for Children (BASC-3) to caregivers when children were a mean age of 23 months, and again at a mean age of 48 months. Primary outcomes were the four BASC-3 composite scales: externalizing problems, internalizing problems, adaptive skills, and the behavioral symptoms index. We imputed missing data using multiple imputation with chained equations. The primary analysis was by intention-to-treat. In a secondary analysis, we evaluated associations between BASC-3 composite indices and modeled trimester-specific PM2.5 concentrations inside residences. Results We enrolled participants at a median of 11 weeks gestation. After excluding miscarriages, still births and neonatal deaths, our analysis included 478 children (233 control and 245 intervention). We observed no differences in the mean BASC-3 scores between treatment groups. An interquartile increase (20.1 µg/m3) in first trimester PM2.5 concentration was associated with higher externalizing problem scores (2.4 units, 95% CI: 0.7, 4.1), higher internalizing problem scores (2.4 units, 95% CI: 0.7, 4.0), lower adaptive skills scores (-1.5 units, 95% CI: -3.0, 0.0), and higher behavior symptoms index scores (2.3 units, 95% CI: 0.7, 3.9). Third trimester PM2.5 concentrations were also associated with some behavioral indices at age 4, but effect estimates were smaller. No significant associations were observed with PM2.5 concentrations during the second trimester or for any of the BASC indices when children were 2 years old. Conclusion We found no benefit of reducing indoor particulate air pollution during pregnancy on parent-reported behaviors in children. Associations between indoor PM2.5 concentrations in the first trimester and behavioral scores among 4-year old children suggest that it may be necessary to intervene early in pregnancy to protect children, but these exploratory findings should be interpreted cautiously. Trial registration ClinicalTrials.gov: NCT01741051

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“…Des études de cohortes mère-enfant ou de naissance (Tableau 3) menées au cours des années 2000, dans différents pays (Etats-Unis, Chine, Europe) ont montré des associations entre l'exposition prénatale ou les premières années de vie aux polluants de l'air (HAP, carbone élémentaire NO2, particules fines…) intérieur ou extérieur à des niveaux habituellement relevés et des perturbations du neurodéveloppement (40)(41)(42)(43)(44)(45)(46)(47)(48). Les associations décrites concernent des effets sur le développement psychomoteur, cognitif (baisse de QI, problèmes d'attention, mémoire de travail) ou comportemental (anxiété, hyperactivité).…”

Section: Données éPidémiologiquesunclassified

Ubiquitous environmental pollutants and neurodevelopment

Etiemble¹,

Cordier²

2022

Environnement Risques Santé

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Des études épidémiologiques longitudinales menées dans différents pays ont évalué les associations entre l'exposition actuelle à des polluants qui sont, ou ont été, très présents dans l'environnement comme le plomb, les polychlorobiphényles (PCB), les dioxines, la pollution atmosphérique et le neurodéveloppement de l'enfant. Ces études de cohorte mère-enfant ou d'enfants décrivent des associations de l'exposition prénatale ou la première année de vie avec des perturbations du développement mental et psychomoteur chez le jeune enfant ainsi que des déficits cognitifs ou des altérations comportementales chez l'enfant plus âgé. L'impact de ces expositions sur le risque de troubles du neurodéveloppement (TND) tels que le trouble déficit d'attention/hyperactivité (TDAH) ou les troubles du spectre autistique (TSA) est également suggéré en particulier avec l'exposition prénatale au plomb pour le TDAH, à la pollution atmosphérique (particules fines) pour le TSA. Les études expérimentales montrent divers modes d'action de ces polluants et leurs mécanismes au niveau moléculaire et cellulaire : stress oxydant, perturbations neuroendocrines et des neurotransmissions, neuroinflammation, ainsi que des modifications épigénétiques qui peuvent altérer le développement cérébral pendant la période embryonnaire et foetale et l'acquisition des compétences cognitives et comportementales pendant l'enfance.

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Prenatal PM2.5 exposure and behavioral development in children from Mexico City

Cited by 46 publications

References 49 publications

Association between Exposure to Particulate Matter during Pregnancy and Multidimensional Development in School-Age Children: A Cross-Sectional Study in Italy

Association between Exposure to Particulate Matter during Pregnancy and Multidimensional Development in School-Age Children: A Cross-Sectional Study in Italy

Portable HEPA filter air cleaner use during pregnancy and children’s behavior problem scores: a secondary analysis of the UGAAR randomized controlled trial

Ubiquitous environmental pollutants and neurodevelopment

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