Prenatal Presentation Supports the In Utero Development of Congenital Leukemia: A Case Report

Bayoumy, Mohamed; Wynn, Tung; Jamil, Altaf; Kahwash, Samir B.; Klopfenstein, Kathryn J.; Ruymann, Frederick B.

doi:10.1097/00043426-200302000-00013

Cited by 21 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Anemia does not appear to be the cause of the hydrops in most cases, possible causes including myocardial infiltration or extensive visceral involvement with congestive heart failure due to increased vascular resistance13. Cases are occasionally diagnosed antenatally, with multiple soft tissue masses, hydrops and hepatosplenomegaly13, 18, 20.…”

Section: Fetal Malignanciesmentioning

confidence: 99%

Metal Ion Coordination to Azole Nucleosides

Müller

Böhme

Lax

et al. 2005

Chemistry A European J

View full text Add to dashboard Cite

To evaluate the possibility of introducing azole nucleosides as building blocks for metal-mediated base pairs in artificial oligonucleotides, imidazole nucleoside, 1,2,4-triazole nucleoside and tetrazole nucleoside have been synthesized and characterized. The X-ray crystal structures of p-toluoyl-protected 1,2,4-triazole and tetrazole nucleosides are reported. Contrary to the situation primarily found for deoxyribonucleosides, the sugar moieties adopt C3'-endo conformations. The acidity of the beta nucleosides increases with increasing number of nitrogen ring atoms, giving pKa values of 6.01 +/- 0.05, 1.32+/-0.05 and <-3, respectively. This decrease in basicity results in a decreasing ability to form 2:1 complexes with linearly coordinating metal ions such as Ag+ and Hg2+. In all cases, the Ag+ complexes are of higher stability than the corresponding Hg2+ complexes. Whereas imidazole nucleoside forms highly stable 2:1 complexes with both metal ions (estimated log beta2 values of >10), only Ag+ is able to reach this coordination pattern in the case of triazole nucleoside (log beta2 = 4.3 +/- 0.1). Tetrazole nucleoside does not form 2:1 complexes at all under the experimental conditions used. These data suggest that imidazole nucleoside, and to a lesser extent 1,2,4-triazole nucleoside, are likely candidates for successful incorporation as ligands in oligonucleotides based on metal-mediated base pairs. DFT calculations further corroborate this idea, providing model complexes for such base pairs with glycosidic bond distances (10.8-11.0 Angstroms) resembling those in idealized B-DNA (10.85 Angstroms).

show abstract

Section: Fetal Malignanciesmentioning

confidence: 99%

Metal Ion Coordination to Azole Nucleosides

Müller

Böhme

Lax

et al. 2005

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…One possible explanation is that it refiects the early onset of intrauterine leukaemia, since embryonic haematopoiesis begins in the undifferentiated mesenchyme. Alternatively, LC may represent a metastatic infiltration of the skin subsequent to undetectable primary bone marrow disease (1,8).…”

Section: Discussionmentioning

confidence: 99%

Aleukaemic Congenital Leukaemia Cutis: A Critical Primary Sign of Systemic Disease

Sotiriou¹,

Manousari²,

Apalla³

et al. 2011

Acta Derm Venerol

View full text Add to dashboard Cite

“…Involvements of the oral and ocular mucosa are quite rare. The causes of congenital leukemia are unknown, but it has been associated with maternal exposure to radiation, maternal dietary exposure to bioflavonoid, maternal use of tobacco and illicit drugs, and inherited conditions, such as, Down's syndrome, neurofibromatosis, Bloom's syndrome, and Fanconi's anemia 13 . Chromosomal instability is a hallmark of congenital leukemia, and the most common karyotypic abnormality involves the myeloid-lineage leukemia gene at the 11q23 translocation breakpoint 7,14 .…”

Section: Discussionmentioning

confidence: 99%