Prenatal sex hormones and finger length: Digit ratio (2D:4D) as a biological marker of early developmental processes in patients with obsessive-compulsive disorder (OCD)

Nitsche, Katharina; Moritz, Steffen; Jelinek, Lena

doi:10.1016/j.jocrd.2020.100525

Cited by 3 publications

(3 citation statements)

References 91 publications

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“…It was found that the severity of ADHD symptoms increased as the 2D:4D ratio decreased in women with ADHD (Stevenson et al, 2007). There was a negative correlation between 2D:4D ratio and OCD symptom severity in male patients (Nitsche et al, 2020). In our study, YGTSS was used to measure tic severity, and a positive correlation was found between right hand 2D:4D ratio and vocal tic severity score.…”

Section: Discussionsupporting

confidence: 45%

“…A meta-analysis study with psychiatric disorders showed that psychiatric subjects (autism spectrum disorder, schizophrenia, addiction, attention de cit hyperactivity disorder (ADHD), mood disorders, and intellectual disability) had a lower 2D:4D than healthy controls (Fusar-Poli et al, 2021a). A recent study in individuals with obsessive compulsive disorder found a negative correlation between 2D:4D ratio and symptom severity, and a positive relationship with age at onset (Nitsche et al, 2020). The 2D:4D ratio was found to be an indicator of addiction regardless of the type of substance used (Erdoğan et al, 2022).…”

Section: Introductionmentioning

confidence: 84%

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The Fingerprints of Fetal Hormones: Investigating Tic Disorder's Origins through 2D:4D Digit Ratio Analysis

Şahin,

Önal,

Hoşoğlu

2024

Preprint

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The high prevalence of tic disorders in males may be related to androgenic steroids during the intrauterine period. During the critical period of fetal development, the release of high levels of gonadal androgens may contribute to the etiology of tic disorders. To investigate the possible association, the ratio of two to four digits (2D:4D) was used as a measure of fetal hormone exposure. Eighty children aged 7–17 years, including 40 children diagnosed with tic disorder and 40 healthy controls, were included in a cross-sectional study. All participants had a psychopathology assessment and their 2D:4D ratio was measured digitally. The 2D:4D ratio in the left hand was significantly higher in the controls than in the cases (p = 0.003). Multivariate logistic regression analysis also supported that low left 2D:4D ratio was independently associated with tic disorder (p = 0.011). Girls showed a positive correlation between right 2D:4D ratio and vocal tic scores (r = 0.715, p = 0.013). However, the 2D:4D ratio did not appear to be significantly associated with comorbidities, age at diagnosis, age at onset of motor tic, vocal tic, or sensory phenomena. The results suggest that fetal hormones exposure may play a role in the development of tic disorders. This study showed that children and young people with tic disorders had a different 2D:4D ratio to healthy controls. A correlation between the ratio and the severity of the symptoms was also found. These novel findings provide a solid basis for further research in this area.

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Section: Discussionsupporting

confidence: 45%

Section: Introductionmentioning

confidence: 84%

The Fingerprints of Fetal Hormones: Investigating Tic Disorder's Origins through 2D:4D Digit Ratio Analysis

Şahin,

Önal,

Hoşoğlu

2024

Preprint

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“…A few studies are addressing OCD patients, such as Fox's Doctoral work in 2019 entitled "A look at the self, self-concept, and stigma resistance among those suffering from OCD" [8]. Another recent study reported prenatal sex hormones and finger length: Digit ratio (2D:4D) as a biological marker of early developmental processes in patients with OCD [9]. When a person knows who she is, has beliefs that are not conflicting, he has such opinions about the self that are constant over time, called high in SCC.…”

Section: Introductionmentioning

confidence: 99%

Obsessive-Compulsive Tendencies & Self-Concept Clarity Among Females With and Without Hormonal Imbalance

Yaqoob

Zahid

2021

J Research Health

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Background: The role of hormones in the female body is well known in reproductive age. Several studies have been conducted regarding hormonal fluctuations and their association with obsessive-compulsive disorder, but the role of psychological issues relevant to it has been ignored and only hormonal fluctuation and its impact were the target. Thus, the main purpose of this study was to examine the relationship between Self-Concept Clarity (SCC) and obsessive-compulsive tendencies (Obsessive-Compulsive Concerns about Cleanliness (OCC) and Obsessive-Compulsive concerns about Harm and Injury (OCHI)). Another objective was to identify the difference between SCC, OCC, and OCHI in healthy and unhealthy females. Methods: A sample of (N=210) females, an equal number of healthy and unhealthy females, from different hospitals and the general population, with a mean age of 21 years, was selected by using convenience sampling technique as a type of non-probability sampling. Study participants were selected from the same city. Results: Comparison of healthy and unhealthy females revealed high levels of SCC and obsessive-compulsive tendencies among unhealthy females and also a significant positive correlation was found between these constructs. Conclusion: The females with irregular hormonal fluctuations develop obsessive-compulsive tendencies and these people are most sensitive to unimportant affairs, even sensitive to themselves that might create clarity in their self-concept.

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Digit ratio (2D:4D) and handedness: A meta-analysis of the available literature

2021

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Prenatal sex hormones and finger length: Digit ratio (2D:4D) as a biological marker of early developmental processes in patients with obsessive-compulsive disorder (OCD)

Cited by 3 publications

References 91 publications

The Fingerprints of Fetal Hormones: Investigating Tic Disorder's Origins through 2D:4D Digit Ratio Analysis

The Fingerprints of Fetal Hormones: Investigating Tic Disorder's Origins through 2D:4D Digit Ratio Analysis

Obsessive-Compulsive Tendencies & Self-Concept Clarity Among Females With and Without Hormonal Imbalance

Digit ratio (2D:4D) and handedness: A meta-analysis of the available literature

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