Prenatal Sonographic Diagnosis of Hemivertebra

Weisz, Boaz; Achiron, R.; Schindler, Amos; Eisenberg, V. H.; Lipitz, Shlomo; Zalel, Yaron

doi:10.7863/jum.2004.23.6.853

Cited by 46 publications

(49 citation statements)

References 10 publications

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“…1,3 Hemivertebrae are nonisolated in 88.5% of neonates when newborn physical features detected by a geneticist's physical examination are additionally considered. 2 The cardiovascular, urinary, skeletal, gastrointestinal, and central nervous systems are most commonly involved.…”

Section: Discussionmentioning

confidence: 99%

“…As confirmed by this study, the thoracic and lumbar portions of the spine are most commonly involved, with single and multiple hemivertebrae occurring with equal frequency. 1,2 Although prenatal diagnoses of hemivertebrae are typically made by 2-dimensional sonography, 3-dimensional sonography is potentially useful in showing the accessory ossification center. 6 We found the 3-dimensional x-ray mode particularly useful (Figures 1 and 2).…”

Section: Discussionmentioning

confidence: 99%

“…2 The cardiovascular, urinary, skeletal, gastrointestinal, and central nervous systems are most commonly involved. [1][2][3] Importantly, these birth defects may occur as part of syndromes that may negatively affect the prognosis, such as VATER syndrome (vertebral anomalies, imperforate anus, tracheoesophageal fistula, and renal anomalies), VACTERL syndrome (VATER with cardiac and limb anomalies), Klippel-Feil syndrome, Jarcho-Levin syndrome, OEIS (omphalocele, bladder exstrophy, imperforate anus, and spine anomalies), the Potter sequence, and open spina bifida. Almost one-third of our neonates had hemivertebrae as part of a syndrome, of which half died.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, fetal karyotypes are usually normal whether the hemivertebrae are isolated or nonisolated, as supported by this study. [1][2][3] However, fetal chromosomal analysis should be considered especially for nonisolated hemivertebrae because an increased risk of aneuploidy may exist.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Despite this incidence, surprisingly few published reports have addressed the importance of prenatally detected hemivertebrae. [1][2][3] Moreover, obstetric outcomes of affected fetuses remain largely unexplored. Therefore, we performed a multicenter retrospective cohort study to evaluate associated anomalies and outcomes of fetuses with prenatally diagnosed hemivertebrae.…”

mentioning

confidence: 99%

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Prenatal Sonographic Diagnosis of Hemivertebrae

Wax

Watson

Miller

et al. 2008

Journal of Ultrasound in Medicine

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Objective. The purpose of this study was to evaluate associated anomalies and outcomes of fetuses with prenatally diagnosed hemivertebrae. Methods. Fetuses with prenatally diagnosed hemivertebrae, excluding those associated with spina bifida, were identified by searching the prospectively maintained ultrasound databases of 4 institutions from 1997 to August 2007. Associated birth defects were tabulated by organ system and hemivertebra location. Outcomes included karyotypes, gestational ages, and routes and outcomes of deliveries. Results. Nineteen fetuses had a diagnosis of hemivertebrae at a mean gestational age ± SD of 20.5 ± 5.4 weeks. Fourteen (73.7%) fetuses had additional anomalies, of which 5 (35.7%) were syndromic (4 with cloacal exstrophy and omphaloceles and 1 with Jarcho-Levin syndrome). Karyotypes were normal in all 11 available cases, each of which had additional anomalies. Fourteen (73.7%) neonates were live born at a mean gestational age of 34.9 ± 4.3 weeks, of which 7 (50%) were born by cesarean delivery. Ten neonates (71.4%) were delivered before term, and 4 (28.6%) were growth restricted (<10th percentile). Two (14.3%) of these neonates died; both had cloacal exstrophy and large omphaloceles. The remaining pregnancies were terminated (4 [21.1%]) or had a fetal death (1 [5.3%]). Conclusions. Most fetuses with prenatally diagnosed hemivertebrae have additional anomalies, often syndromic, which affect the prognosis. Affected pregnancies have high rates of cesarean delivery and growth restriction. Neonates with nonisolated hemivertebrae are more often delivered before term and have higher mortality rates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Prenatal Sonographic Diagnosis of Hemivertebrae

Wax

Watson

Miller

et al. 2008

Journal of Ultrasound in Medicine

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Fetal Skeletal Anomalies

Romero

Athanassiadis

Jeanty

2007

Clinical Obstetrics

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Gastroschisis: Clinical presentation and associations

Hunter

Stevenson

2008

American J of Med Genetics Pt C

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Gastroschisis is a major malformation which requires immediate surgical care to return the exposed viscera to the abdominal cavity, parenteral nutrition until bowel motility permits oral feedings, and evaluation for coexisting malformations. Almost all cases are diagnosed prenatally using midtrimester ultrasound and maternal serum alphafetoprotein measurement. This allows most infants to be delivered in a tertiary care facility where the best mode of delivery and neonatal management can be determined. About 10% of infants with gastroschisis will have other malformations. Half of these are considered related to the gastroschisis (intestinal atresia or stenosis, malrotation, cryptorchidism, amyoplasia, urinary tract obstruction). Other associated malformations occur which are not recognized to be secondary to the gastroschisis. Prominent among these are cardiac and limb defects. Fetal and neonatal mortality are increased, but neither appear related to lethal malformations.

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Prenatal Sonographic Diagnosis of Hemivertebra

Cited by 46 publications

References 10 publications

Prenatal Sonographic Diagnosis of Hemivertebrae

Prenatal Sonographic Diagnosis of Hemivertebrae

Fetal Skeletal Anomalies

Gastroschisis: Clinical presentation and associations

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