Prenatal stress affects behavioral reactivity to an intense stress in adult female rats

Louvart, Hélène; Maccari, Stefania; Darnaudéry, Muriel

doi:10.1016/j.brainres.2004.10.025

Cited by 50 publications

(33 citation statements)

References 47 publications

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“…We confirm in the present study that prenatal stress exacerbates the locomotor reactivity to novelty in adult animals (Deminiere et al 1992;Louvart et al 2005). This behavior is associated with a higher sensitivity to the reinforcing effects of psychostimulants Piazza et al 1989) and correlates with oral alcohol self-administration in an operant paradigm (Nadal et al 2002).…”

Section: Discussionsupporting

confidence: 91%

“…Rats born from dams stressed during the last 10 days of gestation (PRS rats) display a decreased ability to cope with stress (Darnaudery and Maccari 2008;Maccari and Morley-Fletcher 2007), an exacerbated anxiety-like behavior (Vallee et al 1997), a hyper-response to an intense footshock stress (Louvart et al 2005), and depressive-like disturbances (Morley-Fletcher et al 2003). At a neurobiological level, PRS rats show several alterations of neurotransmitter systems involved in the alcohol response, such as glutamatergic (Barros et al 2004;Berger et al 2002;Van Waes et al 2009;Zuena et al 2008), GABAergic (Barros et al 2006), and dopaminergic (Adrover et al 2007; Barros et al 2004;Berger et al 2002;Henry et al 1995) dysfunctions.…”

Section: Introductionmentioning

confidence: 99%

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Effect of prenatal stress on alcohol preference and sensitivity to chronic alcohol exposure in male rats

et al. 2010

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effect of prenatal stress on alcohol preference and sensitivity to chronic alcohol exposure in male rats

et al. 2010

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“…This discrepancy may be due to the differences in stress protocols and the age of rat offspring at examination, etc. On the other hand, previous studies show that prenatal stress alters reactivity to acute stress (Louvart et al, 2005) and induces hyperactivity (Hougaard et al, 2005) and a higher behavioral emotionality in adult rat offspring. In accordance with these previous studies, our study showed that prenatal stress caused higher effects of acute stress on LTP and LTD in the hippocampus.…”

Section: Introductionmentioning

confidence: 95%

Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring

et al. 2006

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Clinical studies demonstrate that prenatal stress causes cognitive deficits and increases vulnerability to affective disorders in children and adolescents. The underlying mechanisms are not yet fully understood. Here, we reported that prenatal stress (10 unpredictable, 1 s, 0.8 mA foot shocks per day during gestational days 13-19) impaired long-term potentiation (LTP) but facilitated long-term depression (LTD) in hippocampal CA1 region in slices of the prenatal stressed offspring (5 weeks old). Cross-fostering neonate offspring by the prenatal stressed or control mothers did not change the effects of prenatal stress on the hippocampal LTP and LTD. Furthermore, prenatal stress enhanced the effects of acute stress on the hippocampal LTP and LTD and impaired spatial learning and memory in the Morris water maze in the young rat offspring. Therefore, prenatal stress alters synaptic plasticity and enhances the effects of acute stress on synaptic plasticity in the hippocampus, which may be the mechanism for the impaired spatial learning and memory in young rat offspring.

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“…Prenatal stress can also delay habituation of the cortisol response when stressors are repeated or chronic (Bhatnagar, Lee, & Vining, 2005). Altered functioning of the HPA axis has in turn been linked to a range of adverse offspring outcomes including deficits in cognitive performance (Gue et al, 2004), heightened emotionality (Vallee et al, 1997;Weinstock, 1997), and stress-induced behavioral disturbances (Griffin, Skinner, Salm, & Birkle, 2003;Louvart, Maccari, & Darnaudery, 2005).…”

Section: Introductionmentioning

confidence: 98%

Maternal prenatal anxiety, postnatal caregiving and infants' cortisol responses to the still‐face procedure

Grant

McMahon

Austin

et al. 2009

Developmental Psychobiology

121

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This study prospectively examined the separate and combined influences of maternal prenatal anxiety disorder and postnatal caregiving sensitivity on infants' salivary cortisol responses to the still-face procedure. Effects were assessed by measuring infant salivary cortisol upon arrival at the laboratory, and at 15-, 25-, and 40-min following the still-face procedure. Maternal symptoms of anxiety during the last 6 months of pregnancy were assessed using clinical diagnostic interview. Data analyses using linear mixed models were based on 88 women and their 7-month-old infants. Prenatal anxiety and maternal sensitivity emerged as independent, additive moderators of infant cortisol reactivity, F (3, 180) = 3.29, p = .02, F (3, 179) = 2.68, p = .05 respectively. Results were independent of maternal prenatal depression symptoms, and postnatal symptoms of anxiety and depression. Infants' stress-induced cortisol secretion patterns appear to relate not only to exposure to maternal prenatal anxiety, but also to maternal caregiving sensitivity, irrespective of prenatal psychological state.

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Prenatal stress affects behavioral reactivity to an intense stress in adult female rats

Cited by 50 publications

References 47 publications

Effect of prenatal stress on alcohol preference and sensitivity to chronic alcohol exposure in male rats

Effect of prenatal stress on alcohol preference and sensitivity to chronic alcohol exposure in male rats

Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring

Maternal prenatal anxiety, postnatal caregiving and infants' cortisol responses to the still‐face procedure

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