Prenylflavonoids from the Twigs of &lt;i&gt;Artocarpus nigrifolius&lt;/i&gt;

Liu, Xi; Kuang, Xiaodong; He, Xiao-Ru; Ren, Gang; Wang, Yong; Xu, Liu-Yun; Liu, Feng; Wang, Bin; Zhou, Zhiliang

doi:10.1248/cpb.c17-00958

Cited by 11 publications

(7 citation statements)

References 36 publications

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“…The air-dried powder of twigs of A. pithecogallus was extracted with 95% EtOH three times at room temperature. The EtOAc-soluble fraction of the EtOH extract was purified using various column chromatographies to afford nine prenylated phenolics (1)(2)(3)(4)(5)(6)(7)(8)(9) (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

“…5) Recent studies on plants of the Artocarpus genus (Moraceae) revealed the presence of a number of prenylated phenolics possessing potent tyrosinase inhibitory activity. [6][7][8] As part of our ongoing efforts to discover novel potential leads from Moraceae plants, 9,10) Artocarpus pithecogallus C. Y. WU, an evergreen tree distributed in the southern part of Yunnan province, P. R. China, has been chemically investigated for the first time. Herein, we describe the structural elucidation of four new prenylated 2-arylbenzofurans as well as the tyrosinase inhibitory activity of all isolated compounds.…”

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confidence: 99%

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Artopithecins A–D, Prenylated 2-Arylbenzofurans from the Twigs of <i>Artocarpus pithecogallus</i> and Their Tyrosinase Inhibitory Activities

Wang

Liu

et al. 2018

Chem. Pharm. Bull.

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Four new prenylated 2-arylbenzofurans, namely artopithecins AD (1-4), together with five known compounds (5-9) were isolated from the twigs of Artocarpus pithecogallus for the first time. Their structures were elucidated based on extensive spectroscopic analysis and in comparison with literature data. All isolates were evaluated for their inhibitory activities against mushroom tyrosinase. Compounds 3 and 4 displayed significant tyrosinase inhibitory activities with IC 50 values of 37.09 0.33 and 38.14 0.21 µM, respectively.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Artopithecins A–D, Prenylated 2-Arylbenzofurans from the Twigs of <i>Artocarpus pithecogallus</i> and Their Tyrosinase Inhibitory Activities

Wang

Liu

et al. 2018

Chem. Pharm. Bull.

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“…Compounds 11 and 12 represent quercetin acyl glycosides, while 13 and 14 are kaempferol acyl glycosides [ 26 ]. Compounds 15–16 were isolated from the twigs of Artocarpus nigrifolius and are prenylated flavones [ 27 ]. Compound 17 is a tetramethoxylated flavone isolated from the leaves and twigs of Murraya tetramera [ 28 ].…”

Section: Isolation Of Novel Flavonoids Isoflavonoids and Neoflavonoidsmentioning

confidence: 99%

“…For both targets, compound 12 exhibited better scores than compound 11 , and compound 14 displayed better scores than compound 13 [ 26 ]. Compounds 15 and 16 showed weak to moderate cytotoxic activities against SiHa and SGC-7901 cells [ 27 ].…”

Section: Bioactivities Of Flavonoids Isoflavonoids and Neoflavonoidsmentioning

confidence: 99%

Perplexing Polyphenolics: The Isolations, Syntheses, Reappraisals, and Bioactivities of Flavonoids, Isoflavonoids, and Neoflavonoids from 2016 to 2022

Umer

Shamim

Khan

et al. 2023

Life

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Flavonoids, isoflavonoids, neoflavonoids, and their various subcategories are polyphenolics–an extensive class of natural products. These compounds are bioactive and display multiple activities, including anticancer, antibacterial, antiviral, antioxidant, and neuroprotective activities. Thus, these compounds can serve as leads for therapeutic agents or targets for complex synthesis; they are coveted and routinely isolated, characterized, biologically evaluated, and synthesized. However, data regarding the compounds’ sources, isolation procedures, structural novelties, bioactivities, and synthetic schemes are often dispersed and complex, a dilemma this review aims to address. To serve as an easily accessible guide for researchers wanting to apprise themselves of the latest advancements in this subfield, this review summarizes seventy-six (76) articles published between 2016 and 2022 that detail the isolation and characterization of two hundred and forty-nine (249) novel compounds, the total and semisyntheses of thirteen (13) compounds, and reappraisals of the structures of twenty (20) previously reported compounds and their bioactivities. This article also discusses new synthetic methods and enzymes capable of producing or modifying flavonoids, isoflavonoids, or neoflavonoids.

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“…Recently, our group has reported some prenylated 2-arylbenzofurans and flavones with tyrosinase inhibitory bioactivities isolated from the twigs of A. pithecogallus . 14 As part of our ongoing efforts to discover novel potential leads from Moraceae plants, 15,16 this plant has been chemically reinvestigated, which led to the isolation of a phenolic derivative possessing an acetal moiety. Herein, we described the isolation and structural elucidation of the new compound and its tyrosinase inhibitory activity.…”

Section: Introductionmentioning

confidence: 99%

Artopithecin K, a new phenolic derivative with tyrosinase inhibitory activity from Artocarpus pithecogallus

Xiong

Liu

et al. 2020

Journal of Chemical Research

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Prenylflavonoids from the Twigs of <i>Artocarpus nigrifolius</i>

Cited by 11 publications

References 36 publications

Artopithecins A–D, Prenylated 2-Arylbenzofurans from the Twigs of <i>Artocarpus pithecogallus</i> and Their Tyrosinase Inhibitory Activities

Artopithecins A–D, Prenylated 2-Arylbenzofurans from the Twigs of <i>Artocarpus pithecogallus</i> and Their Tyrosinase Inhibitory Activities

Perplexing Polyphenolics: The Isolations, Syntheses, Reappraisals, and Bioactivities of Flavonoids, Isoflavonoids, and Neoflavonoids from 2016 to 2022

Artopithecin K, a new phenolic derivative with tyrosinase inhibitory activity from Artocarpus pithecogallus

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