Preoperative assessment of hepatic function: Utility of a new convenient two‐compartment model analysis using galactosyl human serum albumin scintigraphy

Abstract

These results suggest that this new compartment analysis will be useful in evaluating liver function, as it is accurate, simple and convenient.

Can imaging modalities diagnose and stage hepatic fibrosis and cirrhosis accurately?

“…liver uptake, uniformity of hepatic uptake, hepatic left lobe to right lobe ratio, spleen uptake and volume) and Child-Pugh score, indocyanine green test or other classifications of liver disease severity [156][157][158][159][160][161][162][163][164][165][166][167][168][169][170][171][172][173][174]. Successful radiotracers were Technetium-99 m (99m-Tc) sulfur colloid, 99m-Tc-phytate colloid and 99m-Tc diethylenetriamine pentaacetic acidgalactosyl human serum albumin.…”

Preoperative Assessment of Congestive Liver Dysfunction Using Technetium-99 m Galactosyl Human Serum Albumin Liver Scintigraphy in Patients with Severe Valvular Heart Disease

“…Many investigators have reported that some measurements obtained from 99m Tc-GSA liver scintigraphy are strongly correlated with previously identifi ed indicators of hepatic function and that they are useful for assessing hepatic function. [8][9][10][11][12] We found that HH15 and LHL15 levels mildly correlated with preoperative ICGR15 and serum ChE, which may imply that the 99m Tc-GSA measurements indicate a capacity of protein synthesis or bilirubin excretion that differs from the capacity obtained by the evaluation of liver transaminases. The 99m Tc-GSA value could be a simple method of predicting postoperative liver dysfunction.…”

“…They have been confi rmed clinically as useful measures of hepatic function; therefore, 99m Tc-GSA scintigraphy has been recognized as the best method for assessing liver functional reserve, [8][9][10][11][12] achieving results comparable with those obtained by liver biopsy. HH15 represents the retention of the tracer in the blood, and LHL15 illustrates the hepatic uptake of the tracer from the blood.…”

“…[8][9][10][11][12] The 99m Tc-GSA (185 MBq) was injected intravenously, and dynamic images were recorded with the patient lying supine under a large fi eld of view gamma camera with a low-energy, all-purpose, parallel-hole collimator. Computer acquisition of the gamma camera data was started just before the injection of 99m Tc-GSA and stopped 20 min later.…”

“…This technique permits a relatively non-invasive assessment of liver function and is apparently useful for assessing hepatic function in patients with liver dysfunction. [5][6][7][8][9][10][11][12] This asialoscintigraphy is infl uenced by hepatocyte function only, and allows quantitative measurement of the hepatic functional reserve using the index of blood clearance (HH15) and the receptor index (LHL15). 13 We conducted this retrospective study to evaluate the clinical usefulness of the factors obtained from recent asialoscintigraphy, by comparing these factors with the results of various liver function tests performed to assess severe valvular disease.…”