Preoperative assessment of proliferative activity and hormonal receptor status in carcinoma of the breast: A comparison of needle aspiration and needle-core biopsies to the surgical specimen

BackgroundThe objective of this study was to determine the concordance rate between core needle biopsy (CNB) and surgical excision of invasive breast cancer regarding the oestrogen receptor (ER) and Progesterone receptor (PgR) status as determined by Immunohistochemistry (IHC).MethodsHormone receptor status was established using IHC (using quickscore system 0–8) on preoperative CNB and subsequent surgical excision in 93 patients with invasive breast cancer. Results were compared taking into account tumour's size, grade, and patient's age.ResultsThe ER concordance rate between CNB and surgical excisions was 95%. The PgR concordance rate was 89%. This shows that CNB has a sensitivity of 97% for ER and 95% for PgR.There is a positive correlation of ER and PgR between CNB and surgical excision (p < 0.000001). There was no significant difference in the number of core biopsies between concordant and discordant cases.ConclusionPreoperative core biopsy is highly sensitive for the IHC detection of ER and PgR in invasive breast cancer. The concordance rate is higher for ER than PgR, which could be due to the fact that ER is more homogeneously distributed.

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“…Previous studies on a smaller case sample have suggested similar findings regarding ER [10-12]. However, results on PgR were less consistent.…”

Section: Discussionmentioning

confidence: 60%

Is preoperative core biopsy accurate in determining the hormone receptor status in women with invasive breast cancer?

Sarakbi

Salhab

Thomas

et al. 2005

Int Semin Surg Oncol

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“…Several studies have reported on assessment of the HR status using cytological specimens [6][7][8][9][10][11][12][13][14][15][16][17][18]. From the mid 1980s to the late 1990s, the HR status in cytological specimens was reported to show a good correlation with that of biochemical assays [9,11,12,19].…”

Section: Discussionmentioning

confidence: 99%

“…From the mid 1980s to the late 1990s, the HR status in cytological specimens was reported to show a good correlation with that of biochemical assays [9,11,12,19]. More recently, several studies have reported comparison of the HR status by IHC in cytological specimens and frozen [8,10] or paraffinembedded [7,11,13,15,17,18,20] histological sections. All of the literature published until now indicates the existence of a good correlation between the HR status in cytological specimens and that in the corresponding surgical specimens.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of liquid-based cytology in hormone receptor analysis of breast cancer specimens

et al. 2010

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Immunohistochemical (IHC) analysis of the hormone receptor (HR) in breast cancer cytology is an important issue nowadays. Several studies have shown discrepancy in the HR status between the primary tumor and metastases. Cytology can be used for patients with metastatic disease. Although cytological assessment of HR is an excellent method, it has not been routinely used because of the difficulty in consistently preparing multiple good quality slides. Liquid-based cytology (LBC) preparation is considered as the key to resolving the aforementioned problem; however, few studies have reported the HR assessment in breast cancer using LBC. Therefore, the HR status of LBC slides from 82 breast cancers was compared with that of the corresponding surgical specimens. The HR assay in both the LBC slides and surgical specimens was conducted by IHC using an autostainer. For the IHC staining, the protocol recommended by the manufacturer for paraffin-embedded sections was used for both the cytology and histology specimens. The HR results of the cytology agreed with those of the histology in 80 of the 82 cases (accuracy rate, 98%) for estrogen receptor, and in 78 of the 82 cases (accuracy rate, 95%) for progesterone receptor. The overall accuracy of the HR status on the cytology and the histology was 99% in 81 of the 82 cases. In conclusion, in HR analysis of breast cancers, LBC followed by IHC using an autostainer was useful for the standard processing of cytological specimens and showed a good correlation with the results of analysis on the histology specimens.

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“…Specimens were interpreted as positive for ER if Ն 10% of the cells demonstrated nuclear staining. 18,19 Staining intensity was graded semiquantitatively as negative, weak, or strong. A mean value was assigned for smears in which the staining intensity varied from area to area.…”

Section: Scoring Of Estrogen Receptor Positivity and Statistical Analmentioning

confidence: 99%

Optimal fixation conditions for immunocytochemical analysis of estrogen receptor in cytologic specimens of breast carcinoma

Gong

Symmans

Krishnamurthy

et al. 2003

Cancer

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Preoperative assessment of proliferative activity and hormonal receptor status in carcinoma of the breast: A comparison of needle aspiration and needle-core biopsies to the surgical specimen

Cited by 31 publications

References 23 publications

Is preoperative core biopsy accurate in determining the hormone receptor status in women with invasive breast cancer?

Is preoperative core biopsy accurate in determining the hormone receptor status in women with invasive breast cancer?

Usefulness of liquid-based cytology in hormone receptor analysis of breast cancer specimens

Optimal fixation conditions for immunocytochemical analysis of estrogen receptor in cytologic specimens of breast carcinoma

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