Preoperative C-reactive protein-to-albumin ratio predicts anastomotic leak in elderly patients after curative colorectal surgery

Yu, Yongming; Zhou, Wu; Shen, Zhonglei; Cao, Yisheng

doi:10.3233/cbm-190470

Cited by 16 publications

(15 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, only a few reports have indicated associations between preoperative in ammation-based and/or nutritional markers and AL. Yu et al demonstrated CAR was an independent risk factor for AL in elderly patients after curative colorectal surgery [10]. Oshi et al reported PNI as an independent risk factor for AL after laparoscopic total gastrectomy [9].…”

Section: Discussionmentioning

confidence: 99%

“…Several recent studies have reported the utility of various in ammation-based and/or nutritional markers as predictors of postoperative complications and poor prognosis in esophageal cancer, such as the Onodera's prognostic nutritional index (PNI), CRP-to-albumin ratio (CAR) and modi ed Glasgow prognostic score (mGPS), which are calculated based on laboratory data including serum albumin or CRP [6][7][8]. Some studies have reported preoperative PNI, CAR and mGPS as predictors for AL after gastrointestinal cancer surgery [9][10][11]. However, no studies appear to have examined the association between preoperative in ammationbased and/or nutritional markers and AL after esophageal cancer surgery.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preoperative C-reactive Protein-to-albumin Ratio Predicts Anastomotic Leakage After Esophagectomy for Thoracic Esophageal Cancer: a Single-center Retrospective Cohort Study

Sugimoto

Toyokawa

Miki

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Postoperative anastomotic leakage (AL) is associated with not only prolonged hospital stay and increased medical costs, but also poor prognosis in esophageal cancer. Several studies have addressed the utility of various inflammation-based and/or nutritional markers as predictors for postoperative complications. However, none have been documented as specific predictors for AL in esophageal cancer. We aimed to identify predictors of AL after esophagectomy for thoracic esophageal cancer, focusing on preoperative inflammation-based and/or nutritional markers. Methods: We retrospectively analyzed 295 patients who underwent radical esophagectomy for thoracic esophageal squamous cell carcinoma between June 2007 and July 2020. As inflammation-based and/or nutritional markers, Onodera prognostic nutritional index, C-reactive protein (CRP)-to-albumin ratio (CAR) and modified Glasgow prognostic score were investigated. Optimal cut-off values of inflammation-based and/or nutritional markers for AL were determined by receiver operating characteristic curves. Predictors for AL were analyzed by logistic regression modeling. Results: AL was observed in 34 patients (11.5%). In univariate analyses, preoperative body mass index (≥22.1 kg/m2), serum albumin level (≤3.8 g/dL), serum CRP level (≥0.06 mg/dL), CAR (≥0.0139), operation time (>565 min) and blood loss (≥480 ml) were identified as predictors of AL. Multivariate analyses revealed higher preoperative CAR (≥0.0139) as an independent predictor of AL (p = 0.048, odds ratio = 3.02, 95% confidence interval 1.01–9.06).Conclusion: Preoperative CAR may provide a useful predictor of AL after esophagectomy for thoracic esophageal squamous cell carcinoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preoperative C-reactive Protein-to-albumin Ratio Predicts Anastomotic Leakage After Esophagectomy for Thoracic Esophageal Cancer: a Single-center Retrospective Cohort Study

Sugimoto

Toyokawa

Miki

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…And CAR has been used as a prognostic factor in variety of solid cancers including esophageal cancer, lung cancer, gastric cancer, colorectal cancer and so on [36][37][38][39]. Recent reports by Yu et al have found preoperative CAR was an independent risk factor for AL in elderly colorectal cancer patients with a cut-off value of 2.44 [40]. Our study further indicated that postoperative CAR was also an independent risk factor for AL after esophagectomy.…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Postoperative C-reactive Protein-to-Albumin Ratio in Anastomotic Leakage after Esophagectomy

Zhang

et al. 2021

Preprint

View full text Add to dashboard Cite

Introduction: Among the many possible postoperative complications, anastomotic leakage (AL) is the most common and serious. Therefore, the purpose of this study was to explore the ability of various inflammatory and nutritional markers to predict postoperative AL in patients after esophagectomy. Methods: A total of 273 patients were retrospectively evaluated and enrolled into this study. Perioperative, surgery-related, tumor-related and laboratory tests data were extracted and analyzed. The discriminatory ability and optimal cut-off value was evaluated according to the receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed to access the potential risk factors for AL. Results: The overall incidence of AL was 12.5% (34/273). C-reactive protein-to-albumin ratio (CAR) [AUC 0.943 (95% confidence interval (CI) = 0.911–0.976, p < 0.001)] and operation time [AUC 0.747 (95% CI = 0.679–0.815, p < 0.001)] had the greatest discrimination on AL prediction. Multivariate analysis demonstrated that CAR and operation time were two independent risk factors for AL, and CAR (OR = 87.150, p < 0.001) had an advantage over operation time (OR = 11.178, p = 0.011). Conclusion: Operation time and postoperative CAR were two independent predictive indexes for AL. Postoperative CAR greater than 3.00 indicated a high risk of AL. For patients with abnormal postoperative CAR, early non-operative treatment or surgical intervention are needed to reduce the serious sequelae of AL.

show abstract

“…And CRP/ALB ratio has been used as a prognostic factor in variety of solid cancers including esophageal cancer, lung cancer, gastric cancer, colorectal cancer and so on [36][37][38][39]. Recent reports by Yu et al have found preoperative CRP/ALB ratio was an independent risk factor for AL in elderly colorectal cancer patients with a cut-off value of 2.44 [40]. Our study further indicated that postoperative CRP/ALB ratio was also an independent risk factor for AL after esophagectomy.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of postoperative C-reactive protein-to-albumin ratio in anastomotic leakage after esophagectomy

Zhang

et al. 2021

J Cardiothorac Surg

View full text Add to dashboard Cite

Introduction Among the many possible postoperative complications, anastomotic leakage (AL) is the most common and serious. Therefore, the purpose of this study was to explore the ability of various inflammatory and nutritional markers to predict postoperative AL in patients after esophagectomy. Methods A total of 273 patients were retrospectively evaluated and enrolled into this study. Perioperative, surgery-related, tumor-related and laboratory tests data were extracted and analyzed. The discriminatory ability and optimal cut-off value was evaluated according to the receiver operating characteristic (ROC) curve analysis. Univariate and multivariate analyses were performed to access the potential risk factors for AL. Results The overall incidence of AL was 12.5% (34/273). C-reactive protein-to-albumin ratio (CRP/ALB ratio) [AUC 0.943 (95% confidence interval (CI) = 0.911–0.976, p < 0.001)] and operation time [AUC 0.747 (95% CI = 0.679–0.815, p < 0.001)] had the greatest discrimination on AL prediction. Multivariate analysis demonstrated that CRP/ALB ratio and operation time were two independent risk factors for AL, and CRP/ALB ratio (OR = 102.909, p < 0.001) had an advantage over operation time (OR = 9.363, p = 0.020; Table 3). Conclusion Operation time and postoperative CRP/ALB ratio were two independent predictive indexes for AL. Postoperative CRP/ALB ratio greater than 3.00 indicated a high risk of AL. For patients with abnormal postoperative CRP/ALB ratio, early non-operative treatment or surgical intervention are needed to reduce the serious sequelae of AL.

show abstract

Preoperative C-reactive protein-to-albumin ratio predicts anastomotic leak in elderly patients after curative colorectal surgery

Cited by 16 publications

References 41 publications

Preoperative C-reactive Protein-to-albumin Ratio Predicts Anastomotic Leakage After Esophagectomy for Thoracic Esophageal Cancer: a Single-center Retrospective Cohort Study

Preoperative C-reactive Protein-to-albumin Ratio Predicts Anastomotic Leakage After Esophagectomy for Thoracic Esophageal Cancer: a Single-center Retrospective Cohort Study

Predictive Value of Postoperative C-reactive Protein-to-Albumin Ratio in Anastomotic Leakage after Esophagectomy

Predictive value of postoperative C-reactive protein-to-albumin ratio in anastomotic leakage after esophagectomy

Contact Info

Product

Resources

About