Preoperative CA-125 predicts extra-uterine disease and survival in uterine papillary serous carcinoma patients

Abstract

Preoperative elevated serum CA-125 is an independent predictor for the presence of extra-uterine disease and an independent risk factor for survival in UPSC patients.

Cancer Antigen 125 Levels are Significantly Associated With Prognostic Parameters in Uterine Papillary Serous Carcinoma

“…11,12,14Y19 Since then, several studies have shown associations of elevated CA-125 levels with aggressive histological types of endometrial carcinoma, such as carcinosarcoma 17 and UPSC. 1,6,9,11,20 Nevertheless, the routine use of CA-125 as a preoperative biomarker in UPSC has never been established. The pathological and clinical similarity between UPSC and epithelial ovarian cancer and the wide use of CA-125 in the management of epithelial ovarian carcinoma, as a tumor marker, suggest the possibility of a more specific correlation between tumor levels of CA-125 and UPSC characteristics.…”

“…On the other hand, according to our data, women with elevated preoperative CA-125 levels may benefit from this comprehensive staging, which has been associated with better survival. 6,20 The retrospective design is a major limitation of this study. Because of the relative rarity of UPSC and the conduct of this study in a single institution, statistical analysis was performed on a small number of patients.…”

“…8,11 Preoperative imaging (ie, computed tomography and magnetic resonance imaging) has low sensitivity for detecting extrauterine spread. 6,9 The high mortality rate and the extent of surgery required have prompted attempts to identify preoperative factors that may predict extrauterine involvement. Such parameters may contribute to determining the clinical approach and treatment plan.…”

Prognostic Factors of Uterine Serous Carcinoma-A Multicenter Study Original Study

“…Olawaiye et al 21 concluded that preoperative serum CA-125 levels correlated with disease stage in patients with USC. Roelofsen et al 22 showed that preoperative CA-125 greater than 45 U/mL remained significantly associated with extrauterine disease (OR, 6.30; 95% CI, 1.93Y20.62) and decreased survival (HR = 3.12; 95% CI, 1.13Y8.73) in USC patients. Abramovich et al 23 concluded that serum CA-125 levels are a useful indicator of disease response or progression in individuals with USC.…”

Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients

“…Even in apparent clinical early stage disease, USC is found to have unfavorable pathological prognostic factors such as lymphovascular space invasion, lymph node involvement, and microscopic intraperitoneal spread [1,2]. Serum CA125 levels in USC have been assessed in many previous studies [3][4][5][6][7][8][9][10] and their surveillance may be a useful indicator of disease response or progression [9,10] However, data regarding immunohistochemical expression of CA125 in USC tissue are very scarce [11].…”