Preoperative Diagnosis of Lymph Node Metastases of Colorectal Cancer by FDG-PET/CT

Tsunoda, Yoshiyuki; Ito, Masaaki; Fujii, Hirofumi; Kuwano, Hiroyuki; Saitô, Norio

doi:10.1093/jjco/hyn032

Cited by 98 publications

(82 citation statements)

References 19 publications

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“…In a study, which located 40 intra-abdominal lymph node recurrences from colorectal cancer, FDG-PET combined with CT was found to have sensitivity of 100%, specificity of 40%, PPV of 93%, and NPV of 100% [39]. In another paper however, PET was noted to have low sensitivity but high specificity (28.6% and 92.9% respectively) [40]. In comparison, PET scan was also found to be low in sensitivity but high in specificity as seen in Grobmyer et al in this review [29].…”

Section: Discussionmentioning

confidence: 97%

Pre-Operative Perihepatic Lymph Node Assessment in Colorectal Cancer Liver Metastasis—A Review of Current Literature

Yong¹,

Burrows²,

Christophi³

2017

OJMI

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Objective: Perihepatic lymph node involvement in colorectal cancer liver metastases is a negative prognostic factor. Resection of certain nodal stations around the liver has been shown to possibly improve survival. The aim of this review is to interrogate current literature on pre-operative investigations in diagnosing lymph node involvement. Method: A systematic review was conducted of articles published since 2006 to determine usefulness of pre-operative imaging in diagnosing lymph node involvement in colorectal cancer liver metastases. Results: Only 2 papers met the inclusion criteria for this study. Computed tomography (CT) scans were found to have sensitivities of 33% and 40%, specificities of 94% and 92%, positive predictive values (PPV) of 56% and 30%, and negative predictive values (NPV) of 85% and 95%. Positron emission tomography (PET) was studied in one of the paper and was found to have sensitivity, specificity, PPV and NPV of 57%, 100%, 100%, and 88% respectively. Conclusion: There is a significant lack of research on pre-operative investigations of perihepatic lymph node involvement in colorectal cancer liver metastases. Pre-operative CT and PET scans in assessing perihepatic lymph nodes were shown to be inaccurate. Newer pre-operative imaging modalities and research would be needed.

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Section: Discussionmentioning

confidence: 97%

Pre-Operative Perihepatic Lymph Node Assessment in Colorectal Cancer Liver Metastasis—A Review of Current Literature

Yong¹,

Burrows²,

Christophi³

2017

OJMI

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“…The mean age of the patients in the two studies was 60 53 and 61 54 years, respectively, with a range of 23-89 years. Rectal cancer affected 104 patients and cancer of the colon affected 37.…”

Section: Patient Populationsmentioning

confidence: 99%

“…The search identified two studies 53,54 that evaluated the diagnostic test accuracy of integrated FDG PET/CT for the detection of primary CRC.…”

Section: Number Of Included Studiesmentioning

confidence: 99%

“…In one study, 53 lymph node metastases were qualitatively diagnosed by abnormal uptake regardless of node shape or size (visual diagnosis). A maximal nodal diameter (size diagnosis) cut-off value of 10 mm was used; maximum standardised uptake value (SUV max ) of lymph nodes with greater uptake than normal organs or surrounding tissue (SUV diagnosis): the optimal cutoff value was where accuracy was greatest; when more than one lymph node in the proximal or distant region was malignant, the one with the highest SUV was used in the analysis.…”

Section: Image Interpretationmentioning

confidence: 99%

“…Where the information was reported, patients were scanned 60 minutes after the administration of the radioactive tracer. 53 Neither study used contrast-enhanced CT.…”

mentioning

confidence: 99%

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The value of FDG positron emission tomography/computerised tomography (PET/CT) in pre-operative staging of colorectal cancer: a systematic review and economic evaluation.

Brush

Boyd²,

Chappell³

et al. 2011

Health Technol Assess

115

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTAThe value of FDG positron emission tomography/computerised tomography (PET/CT) in pre-operative staging of colorectal cancer: a systematic review and economic evaluation NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of ...

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The additional diagnostic impact of positron emission tomography–computed tomography for lymph node metastasis from colorectal cancer: A prospective lymph node level analysis

Todate

Honda

Takada

et al. 2021

Journal of Surgical Oncology

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Background: We conducted a prospective study to determine the diagnostic performance of positron emission tomography-computed tomography (PET-CT) for lymph node metastasis in colorectal cancer patients. Methods:We enrolled patients scheduled to receive curative surgery with lymph node dissection for colorectal adenocarcinoma who underwent contrast-enhanced abdominopelvic CT and PET-CT before surgery and who had primary lesions of cT2 or deeper. A radiologist determined the fluorodeoxyglucose uptake and the standardized uptake value (SUV) and metabolic volume (MV) to diagnose metastasis in cases with enlarged lymph nodes (≥7 mm long in minor diameter) on contrastenhanced CT. Two gastrointestinal surgeons intraoperatively identified target lymph nodes to assess the association between images and pathological findings. The diagnostic performance (i.e., sensitivity, specificity, and positive and negative predictive values) for lymph node metastasis was determined using multilevel logistic modeling.Results: A total of 205 colorectal cancer patients were enrolled from February 2018 to April 2020 and 194 patients were analyzed in this study. The sensitivity, specificity, and positive and negative predictive values of PET-CT were 15.3% (13.4%-17.5%), 100.0% (99.0%-100.0%), 100.0% (51.2%-100.0%), and 98.7% (98.5%-99.0%), respectively. Conclusion:PET-CT is a useful modality for determining the presence of metastasis in swollen lymph nodes on contrast-enhanced CT in colorectal cancer patients.

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Preoperative Diagnosis of Lymph Node Metastases of Colorectal Cancer by FDG-PET/CT

Abstract: FDG-PET/CT is useful for preoperative diagnosis of distant LN metastases of colorectal cancers.

Cited by 98 publications

References 19 publications

Pre-Operative Perihepatic Lymph Node Assessment in Colorectal Cancer Liver Metastasis—A Review of Current Literature

Pre-Operative Perihepatic Lymph Node Assessment in Colorectal Cancer Liver Metastasis—A Review of Current Literature

The value of FDG positron emission tomography/computerised tomography (PET/CT) in pre-operative staging of colorectal cancer: a systematic review and economic evaluation.

The additional diagnostic impact of positron emission tomography–computed tomography for lymph node metastasis from colorectal cancer: A prospective lymph node level analysis

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