Preoperative Hypoxyradiotherapy of Colorectal Carcinoma

Abstract

We believe it can be concluded that acute hypoxia has a radioprotective effect on normal tissues during accelerated hypoxyradiotherapy of colorectal carcinoma. Hypoxyradiotherapy permits safe administration of doses higher than those tolerated by normoxic, noncanceorus tissue, resulting in the amplification of the biological effect of radiation on tumor tissue and contributing to an improved outcome after combined radiosurgical treatment of colorectal carcinoma.

Hypoxic Versus Normoxic External-Beam Irradiation of Cervical Carcinoma Combined with Californium-252 Neutron Brachytherapy

“…The appearance of early or late side effects and complications was minimized and the biological effect was markedly higher compared to conventional preoperative irradiation [38]. The significance of hypoxyradiotherapy in decreasing the side effects and complications of irradiation is supported by the results of other investigations as well [13].…”