Preoperative Lymphedema-Related Risk Factors in Early-Stage Breast Cancer

İyigün, Zeynep Erdoğan; Duymaz, Tomris; İlgün, Ahmet Serkan; Alço, Gül; Ordu, Çetın; Sarsenov, Dauren; Aydin, A.; Çelebi, Filiz; İzci, Filiz; Eralp, Yeşim; Özmen, Vahit

doi:10.1089/lrb.2016.0045

Cited by 37 publications

(30 citation statements)

References 47 publications

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“…In a recent study, lymphedema rates were also found to be higher in patients undergoing axillary lymph node dissection, and among those with a more advanced stage of disease, in addition to having a higher BMI [ 12 , 14 , 32 ]. Additionally, not only are obese women at greater risk for developing post-operative lymphedema, but obese women are also at a higher risk of pre-operative lymphedema [ 44 •, 45 ].…”

Section: Lymphedemamentioning

confidence: 99%

The Impact of Obesity on Breast Cancer Diagnosis and Treatment

et al. 2019

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Purpose of Review Obesity is a recognized risk factor for the development of breast cancer and recurrence even when patients are treated appropriately. We reviewed the literature that addresses the impact of obesity on diagnosis and the individual therapeutic interventions, and present a summary of the findings. Recent Findings Compared to non-obese women with breast cancer, obese women with breast cancer have a worse disease-free and overall survival despite appropriate local and systemic therapies. In brief, obese breast cancer patients experience more complications related to surgery, radiation, and chemotherapy. Further, obese patients are at increased risk for local recurrence compared to normal-weight women. Similarly, systemic chemotherapy is less effective, even when dosed appropriately on the basis of actual weight. Overall, endocrine therapy is less effective in obese women, and there is a suggestion that aromatase inhibitors may be selectively less effective than tamoxifen. Obese women are less likely to undergo breast reconstruction than normal-weight women, and those who do have surgery experience more surgical complications. Summary The efficacy of cancer treatments is significantly lower in obese breast cancer survivors, posing greater challenges in patient care and disease management in this patient population. Further investigations are warranted to assess the effects on treatment outcomes and optimize therapeutic mechanisms in order to successfully target breast cancer associated with obesity.

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Section: Lymphedemamentioning

confidence: 99%

The Impact of Obesity on Breast Cancer Diagnosis and Treatment

et al. 2019

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“…Currently, there is no reliable way of distinguishing patients who are likely to develop lymphedema, but a consensus has been reached on some well-defined risk factors, including axillary lymph node dissection (ALND), which is associated with early-onset disease (22), regional lymph node radiotherapy, which is related to late-onset disease (22), high body mass index (BMI) at the time of breast cancer diagnosis (BMI ≥25 kg/m 2 ) (23), a high number of positive lymph nodes (>8) (24) and capsular invasion of the tumor (24).…”

Section: Risk Factorsmentioning

confidence: 99%

Lymphedema in survivors of breast cancer (Review)

et al. 2020

Oncol Lett

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The tremendous improvement of survival in patients with breast cancer can be attributed to several treatment strategies, but these strategies also lead to the occurrence of breast cancer-related lymphedema (BCRL). BRCL is regularly associated with factors such as axillary lymph node dissection and local lymph node radiotherapy and manifests as an increase of >10% in the volume of affected limbs. Being overweight or having obesity (body mass index ≥25 kg/m 2 ), an excessive number of positive lymph nodes (>8) and capsular invasion by a tumor are additional risk factors for lymphedema. It is worth assessing the risk before surgery as this can prevent the occurrence of BCRL at the initial stage of breast cancer management. The clinical utility of many diagnostic tools and lymphedema surveillance allows early stage and even subclinical BCRL to be diagnosed, and allows real-time monitoring of the disease. The early diagnosis of BRCL allows treatment at an early stage, which is beneficial to the reduction of excess limb volume and the improvement of quality of life. At present, the major therapeutic methods of BCRL include complex decongestive therapy, pneumatic compression devices, participating in exercise, microsurgery and liposuction, each of which alleviates lymphedema effectively. No medications for treatment of BRCL have yet been developed. However, the recent findings on the success of molecular therapy in animal models may remedy this deficiency. Furthermore, the volume reduction of swollen limbs without swelling rebound by transplanting autologous stem cells has been successfully reported in some pilot studies, which may provide a new technique for treating BCRL. This review aimed to discuss the pathogenesis, clinical manifestation, risk factors, advantages and disadvantages of diagnostic tools, lymphedema surveillance and the characteristics of traditional and newly emerging BCRL treatments.

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“…Não existem muitos estudos mostrando a incidência de linfedema após quimioterapia neoadjuvante ou antes da cirurgia; uma das causas poderia ser o edema subclínico do membro superior que muitas vezes é subestimado. Estudo com mulheres indicadas à cirurgia para o câncer de mama constatou, por meio da bioimpedância, linfedema em 17,7% daquelas que não tinham sintomas clínicos, nem alteração da circunferência dos membros superiores 13 .…”

Section: Discussionunclassified

“…Em nosso estudo, a paciente desenvolveu linfedema após a quimioterapia neoadjuvante e o laudo histopatológico confirmou quatro linfonodos comprometidos. Iyigun et al 13 afirmaram que o comprometimento de linfonodos axilares é um fator de risco para o linfedema subclínico.…”

Section: Discussionunclassified

Abordagem Fisioterapêutica de uma Paciente com Linfedema de Membro Superior Prévio à cirurgia para Câncer de Mama: Relato de caso

Fabro

Lou

Macedo

et al. 2018

Rev. Brasileira.De.Cancerologia

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Introdução: O linfedema e a complicacao mais comum apos o tratamento do cancer de mama. Quando se manifesta antes do tratamento cirurgico, como condicao clinica por si so, e visto como um criterio de inoperabilidade, representando um fator de mau prognostico. Relato do caso: Este artigo visa a descrever a evolucao clinica de uma paciente com linfedema de membro superior previo a cirurgia para o cancer de mama, a conducao do tratamento fisioterapeutico e a viabilidade do procedimento cirurgico. Conclusão: Por meio deste relato de caso, foi possivel descrever o tratamento fisioterapeutico de uma paciente com linfedema previo a cirurgia para o câncer de mama. A equipe de fisioterapia pode atuar em parceria com a equipe medica, controlando a descompensacao linfatica e auxiliando no caminho ate a realizacao do procedimento cirurgico. O cuidado fisioterapeutico se mostra fundamental desde o inicio do tratamento oncologico, de forma a detectar precocemente sintomas e disturbios, intervindo de maneira eficaz e resolutiva e buscando proporcionar qualidade de vida e os melhores resultados possiveis para as pacientes.

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Preoperative Lymphedema-Related Risk Factors in Early-Stage Breast Cancer

Cited by 37 publications

References 47 publications

The Impact of Obesity on Breast Cancer Diagnosis and Treatment

The Impact of Obesity on Breast Cancer Diagnosis and Treatment

Lymphedema in survivors of breast cancer (Review)

Abordagem Fisioterapêutica de uma Paciente com Linfedema de Membro Superior Prévio à cirurgia para Câncer de Mama: Relato de caso

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