Preoperative neutrophil-to-lymphocyte ratio (preNLR) for the assessment of tumor characteristics in lung adenocarcinoma patients with brain metastasis

Cui, Huanhuan; Yang, Yuechao; Feng, Mingtao; Gao, Yang; Li, Liangdong; Tu, Wenjing; Chen, Xin; Hao, Bin; Li, Sen; Li, Deheng; Chen, Lei; Zhou, Changshuai; Cao, Yiqun

doi:10.1016/j.tranon.2022.101455

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…It is well known that peripheral blood cells are closely related to tumors. Many studies have reported that neutrophil to lymphocyte ratio (NLR) is closely related to the occurrence and development of many solid tumors, and can be useful for predicting the tumor grade and the prognosis in many tumors [21] , [22] , [23] . Based on our preliminary experiments (Table S1), we found that the NLR of peripheral blood of tumor-bearing mice at 10 d after inoculation produced a significant difference from that at the early stage (tumor bearing day 3) ( P < 0.01), indicating that the immune environment with pro-tumorigenic properties of the organism developed strongly.…”

Section: Methodsmentioning

confidence: 99%

Blockade of neutrophil recruitment to tumor sites based on sialic acid-modified nanoplatforms enhances the efficacy of checkpoint blockade immunotherapy

Chen

Meng

et al. 2023

Asian Journal of Pharmaceutical Sciences

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Section: Methodsmentioning

confidence: 99%

Blockade of neutrophil recruitment to tumor sites based on sialic acid-modified nanoplatforms enhances the efficacy of checkpoint blockade immunotherapy

Chen

Meng

et al. 2023

Asian Journal of Pharmaceutical Sciences

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Preoperative Blood Counts Predict Overall Survival in Patients Undergoing Surgical Removal of Brain Metastasis

Matsuda,

Maeoka,

Morimoto

et al. 2024

World Neurosurgery

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Prognostic value of pre-treatment neutrophil-to-lymphocyte ratio in patients with brain metastasis from cancer: a meta-analysis

Zhou,

Wan,

et al. 2024

Sci Rep

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Evidence shows that inflammatory responses play an essential role in the development of brain metastases (BM). The goal of this meta-analysis was to critically evaluate the literature regarding the use of the neutrophil to lymphocyte ratio (NLR) to predict the prognosis of patients with BM to help clinicians institute early interventions and improve outcomes. We conducted systematic review and meta-analysis, utilizing data from prominent databases, including PubMed, Cochrane Library and China National Knowledge Infrastructure databases. Our inclusion criteria encompassed studies investigating the studies that assessed the association between NLR and overall survival (OS). We included 11 articles, with 2629 eligible patients, to evaluate the association between NLR and OS. High NLR was significantly associated with shorter OS, with a pooled hazard ratio (HR) of 1.82 (95% CI 1.57–2.11). Subgroup analysis revealed that this association was consistent across different regions, with HRs of 2.03 (95% CI 1.67–2.46) in Asian populations and 1.58 (95% CI 1.35–1.84) in non-Asian populations. Additionally, in a subgroup analysis based on NLR cut-off values, patients with NLR ≥ 3 had an HR of 1.69 (95% CI 1.46–1.96), while those with NLR < 3 had an HR of 2.26 (95% CI 1.64–3.11). Sensitivity analysis confirmed that no single study significantly influenced the pooled effect size. Our meta-analysis confirmed the prognostic value of NLR in patients with brain metastasis.

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Preoperative neutrophil-to-lymphocyte ratio (preNLR) for the assessment of tumor characteristics in lung adenocarcinoma patients with brain metastasis

Cited by 3 publications

References 48 publications

Blockade of neutrophil recruitment to tumor sites based on sialic acid-modified nanoplatforms enhances the efficacy of checkpoint blockade immunotherapy

Blockade of neutrophil recruitment to tumor sites based on sialic acid-modified nanoplatforms enhances the efficacy of checkpoint blockade immunotherapy

Preoperative Blood Counts Predict Overall Survival in Patients Undergoing Surgical Removal of Brain Metastasis

Prognostic value of pre-treatment neutrophil-to-lymphocyte ratio in patients with brain metastasis from cancer: a meta-analysis

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