Preoperative platelet–lymphocyte ratio is an independent factor of poor prognosis after curative surgery for colon cancer

Abstract

Interaction between tumour and host triggers a systemic inflammatory response. This situation has been associated to cancer progression. Several peripheral blood inflammatory scores have been recently developed, as PLR. Data about the relationship between these scores and cancer prognosis are contradictory. Therefore, the aim of our work is to evaluate the capability of PLR to predict long-term outcomes (OS and RFS) in patients who underwent curative surgery for colon cancer. A retrospective study was designed with patients who underwent curative surgery for colon cancer between September 2008 and January 2012 at Rio Hortega University Hospital, Valladolid (Spain). We analysed the influence of PLR and other clinical variables on OS and RFS. Finally, 201 patients were analysed. Optimal cut-off value for PLR, established with ROC curves, was 153. 1-, 3- and 5-year OS were: 99.0, 90.4 and 82.3% for low PLR, and 93.8, 74.9 and 61.9% for high PLR, p < 0.001. 1-, 3- and 5-year RFS were: 92.4, 84.7 and 77.6% for low PLR, and 83.3, 64.5 and 52.6% for high PLR, p < 0.001. In MVA, high PLR was an independent negative prognostic factor for OS (HR = 2.11; 95% CI 1.22-3.66; p = 0.008) and RFS (HR = 1.99; 95% CI 1.19-3.34; p = 0.009). PLR represents an independent negative prognostic factor for OS and RFS in our sample of patients who underwent curative surgery for colon cancer. However, further studies with a larger sample size from different populations are necessary to confirm this conclusion.

Neutrophil-to-lymphocyte ratio has limited predictive value for determining outcomes in perforated colon cancer: a retrospective study.

“…Therefore, several systemic in ammatory-associated markers, such as C-reactive protein, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, and NLR, have been used as outcome predictors [4][5][6][7].…”

“…Increasing reports have shown that systemic in ammatory reactions increase the risk of cancer development [2,3]. A number of studies have focused on in ammation-related prognostic variables, such as C-reactive protein and albumin levels, platelet-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio (NLR), to identify patients at a high risk of colorectal cancer recurrence after primary surgery [4][5][6][7].…”

Neutrophil-to-lymphocyte ratio has limited predictive value for determining outcomes in perforated colon cancer: a retrospective study.

“…In colon cancer, systemic in ammation not only affects cytokines, but also promotes angiogenesis and metastasis formation [12]. Therefore, several systemic in ammatory-associated markers, such as C-reactive protein, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, and NLR, have been used as outcome predictors [4][5][6][7].…”

“…Several studies have focused on in ammation-based prognostic factors, such as C-reactive protein and albumin levels, platelet-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio (NLR), to identify patients at a high risk of colorectal cancer recurrence after primary surgery [4][5][6][7].…”

<p>Prognostic Significance of Preoperative Gamma-Glutamyltransferase to Alkaline Phosphatase Ratio in Hepatocellular Carcinoma Patients with Curative Liver Resection: A Retrospective Cohort Study</p>

“…Other immuneinflammation indices, such as NLR, PLR, GARI and GPRI associated with HCC patient prognosis were calculated as previously described. [10][11][12][13] The cutoff values for preoperative GAR, PLR, NLR GAIR and GPIR were decided by applying receiver operating characteristic (ROC) curves and determining the maximum Youden index for each curve.…”