Preoperative SCC Antigen, CRP Serum Levels, and Lymph Node Density in Oral Squamous Cell Carcinoma

Adel, Mohamad; Tsao, Chung‐Kan; Wei, Fu‐Chan; Chien, Huei-Tzu; Lai, Chih-Hsiung; Liao, Chun‐Ta; Wang, Hung‐Ming; Fan, Kang‐Hsing; Kang, Chung‐Jan; Chang, Joseph Tung-Chieh; Huang, Shiang‐Fu

doi:10.1097/md.0000000000003149

Cited by 23 publications

(25 citation statements)

References 48 publications

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“…SCC-Ag is acknowledged as an essential biomarker in head and neck cancer, and the levels of SCC-Ag associated with disease metastasis, recurrence, and mortality of head and neck cancer patients have been examined in many studies [5][6][7][8][9][10][11][12]. SCC-Ag has also been shown to be useful in monitoring treatment response [13].…”

Section: Discussionmentioning

confidence: 99%

“…This study made use of an SCC-Ag reference cutoff value of 2 ng/mL, established previously [6,10,[16][17][18] to analyze the correlation with tumor volume. In the group of patients with an SCC-Ag level < 2 ng/mL, the mean tumor volume was 7.90 mL.…”

Section: Discussionmentioning

confidence: 99%

“…The squamous cell itself produces an antigen (Ag), the presence of which is expected to be higher in cancer patients, and the SCC-Ag has been proven to be a significant tumor marker in many squamous cell-related cancers such as gynecologic, lung, esophageal, and anal cancers [1][2][3][4]. Focusing on head and neck cancer, high levels of SCC-Ag have been associated with disease metastasis, recurrence, and mortality in several studies [5][6][7]. However, studies on the level of SCC-Ag tumor volume relationship are lacking.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Serum Squamous Cell Carcinoma Antigen Level and Tumor Volume in Head and Neck Cancer

Jantharapattana

Kotamnivates

Hirunpat

et al. 2018

ORL

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Purpose of Study: An association of squamous cell carcinoma antigen (SCC-Ag) level with cancer prognosis has been reported in many studies. Our investigators conducted the first study determining a correlation between the SCC-Ag level and the tumor volume in head and neck cancer. Procedures: The SCC-Ag level of patients were measured from the serum, whilst the tumor volume was calculated by the ellipsoid formula and verified by logistic software on radiology. The correlation between SCC-Ag level and tumor volume was analyzed. Results: Fifty-two patients were studied, with the mean age of 62.4 years. Tumor types were: oral cavity cancer (11 cases, 21.6%), oropharyngeal cancer (21 cases, 40.38%), hypopharyngeal cancer (8 cases, 15.7%), and laryngeal cancer (12 cases, 23.5%). Mean tumor volume was 20.01 mL (range 0.02–91.46 mL). Mean SCC-Ag level was 2.69 ng/mL (range 0.5–14.6 ng/mL). The critical point of SCC-Ag was 5.8 ng/mL. The Pearson’s correlation coefficient between SCC-Ag level and tumor volume was 0.524 (p = 0.0002). Conclusions: SCC-Ag moderately correlates with tumor volume in head and neck cancer patients, with statistical significance. We suggest that using tumor volume, rather than a one-dimensional measurement such as tumor size, to analyze correlation with SCC-Ag offers a more accurate means of cancer prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation between Serum Squamous Cell Carcinoma Antigen Level and Tumor Volume in Head and Neck Cancer

Jantharapattana

Kotamnivates

Hirunpat

et al. 2018

ORL

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“…Additionally, nasopharyngeal carcinomas have low expression of SCCA1 . In contrast to the tissue proteomic levels, the pretreated OSCC patients have elevated serum level of SCCA1, correlating with disease progression . The enhancement in the serum SCCA1 levels has been commonly reported in patients suffering from squamous cell carcinomas of head and neck, oesophagus, lung, vulva, and cervix.…”

Section: Discussionmentioning

confidence: 99%

Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut, and alcohol: Case study

Khowal

Naqvi

Monga

et al. 2018

J of Cellular Biochemistry

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The intriguing molecular pathways involved in oral carcinogenesis are still ambiguous. The oral squamous cell carcinoma (OSCC) ranks as the most common type constituting more than 90% of the globally diagnosed oral cancers cases. The elevation in the OSCC incidence rate during past 10 years has an alarming impression on human healthcare. The major challenges associated with OSCC include delayed diagnosis, high metastatic rates, and low 5-year survival rates. The present work foundations on reverse genetic strategy and involves the identification of genes showing expressional variability in an OSCC case lacking addictive proclivities for tobacco, betel nut, and/or alcohol, major etiologies. The expression modulations in the identified genes were analyzed in 16 patients comprising oral pre-cancer and cancer histo-pathologies. The genes SCCA1 and KRT1 were found to down regulate while DNAJC13, GIPC2, MRPL17, IG-Vreg, SSFA2, and UPF0415 upregulated in the oral pre-cancer and cancer pathologies, implicating the genes as crucial players in oral carcinogenesis.

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“…Measuring serum concentrations of SCCA constitutes a simple method that has previously been proposed to be of potential use for the diagnosis and follow-up of HNSCC patients (29)(30)(31)(32). While the information gained from serum analysis vs. mRNA levels in tumours are likely different, it is interesting to consider the regulation of SERPINB3/B4 mRNA levels in HNSCC and its potential implications for the use of SCCA.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours

Saidak

Morisse

Chatelain

et al. 2018

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Preoperative SCC Antigen, CRP Serum Levels, and Lymph Node Density in Oral Squamous Cell Carcinoma

Abstract: Supplemental Digital Content is available in the text

Cited by 23 publications

References 48 publications

Correlation between Serum Squamous Cell Carcinoma Antigen Level and Tumor Volume in Head and Neck Cancer

Correlation between Serum Squamous Cell Carcinoma Antigen Level and Tumor Volume in Head and Neck Cancer

Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut, and alcohol: Case study

Squamous Cell Carcinoma Antigen-encoding Genes SERPINB3/B4 as Potentially Useful Markers for the Stratification of HNSCC Tumours

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