Preoperative Serum Tumor Marker Levels in Gastric Cancer

Polat, Erdal; Duman, Uğur; Duman, Mustafa; Peker, Kıvanç Derya; Akyüz, Cebrail; N, Fatih Yasar; Uzun, Orhan; Akbulut, Sabiye; E, Birol Bostanci; Yol, Sinan

doi:10.12669/pjms.301.3968

Cited by 15 publications

(6 citation statements)

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“…Moreover, only elevated CEA was significantly associated with M stage [24]. We also analyzed the association between preoperative serum tumor markers and clinicopathological traits, and found that pT stage, pN stage, M stage and pTNM stage were significantly correlated with the positivity of three tumor markers, which was consistent with previous studies [17, 25].…”

Section: Discussionsupporting

confidence: 89%

Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

et al. 2016

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The prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma (GC) has been widely reported and is still under debate. Here, we evaluated the prognostic significance of preoperative serum CA125, CA19-9 and CEA in patients with GC. 1692 patients with GC who underwent gastrectomy were divided into the training (from January 2005 to December 2011, n = 1024) and the validation (from January 2012 to December 2013, n = 668) cohorts. Positive groups of CA125 (> 13.72 U/ml), CA19-9 (> 23.36 U/ml) and CEA (> 4.28 ng/ml) were significantly associated with more advanced clinicopathological traits and worse outcomes than that of negative groups (all P < 0.01). In Cox regression analysis, tumor size (P < 0.001, P = 0.005), pTNM stage (P < 0.001, P < 0.001) and CA125 (P = 0.026, P = 0.005) were independent prognostic factors both in two cohorts. Nomograms of these two cohorts based on the number of positive serum tumor markers (NPTM) were more accurate in prognostic prediction than TNM stage alone. Our findings suggested that elevated preoperative serum CA125, CA19-9 and CEA were associated with more advanced clinicopathological traits and less favorable outcomes. In addition, CA125 as an independent prognostic factor should be further investigated. Nomogram based on NPTM could accurately predict the prognosis of GC patients.

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Section: Discussionsupporting

confidence: 89%

Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

et al. 2016

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“…Cancer antigen 125 (CA125) is a glycoprotein that is expressed by tissue derived from coelomic epithelium and has a molecular weight estimated to range from 110 to more than 2000 kD [1]. The CA125 serum level has been shown to be increased in women with ovarian cancer and less often in breast [2], lung [3] and gastrointestinal cancers [4]. However, it is not a screening test for malignancies as it may also be elevated in a variety of benign conditions (such as pregnancy, endometriosis, uterine leiomyomata, pelvic inflammatory disease, cirrhosis, peritonitis, pleuritis, pancreatitis, and tuberculosis) [5].…”

Section: Introductionmentioning

confidence: 99%

CA125 as a Marker of Heart Failure in the Older Women: A Population-Based Analysis

Bulska-Będkowska

Chełmecka

Owczarek

et al. 2019

JCM

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(1) Background: Cancer antigen 125 (CA125) is a glycoprotein that is expressed by tissue derived from coelomic epithelium in the pleura, peritoneum, pericardium. It has been shown that CA125 concentrations are correlated with NT-proBNP in older people with congestive heart failure (HF). We conducted a study on the association between concentrations of CA125 and NT-proBNP in a population-based cohort of older Polish women. (2) Methods: The current research is sub-study of a large, cross-sectional research project (PolSenior). The study group consisted of 1565 Caucasian women aged 65–102 years. To assess the relationship between CA125 and other variables a stepwise backward multivariate normal and skew-t regression analyses were performed. (3) Results: The median of CA125 concentration was 13.0 U/mL and values over the upper normal range limit (35 U/mL) were observed in 5.1% (n = 79) of the study cohort. The concentration of CA125 was positively related to age, hospitalization for HF and history of atrial fibrillation and chronic obstructive pulmonary disease, levels of NT-proBNP, IL-6, hs-CRP and triglycerides. We found in the multivariate analyses, that increased CA125 levels were independently associated with log10 (IL-6) (β = 11.022), history of hospitalization for HF (β = 4.619), log10 (NT-proBNP) (β = 4.416) and age (β = 3.93 for 10 years). (4) Conclusions: Despite the association between CA125 and NT-proBNP, the usefulness of CA125 for the detection of HF in older women is limited by factors such as inflammatory status and age.

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“…In this study, 82 patients had elevated serum CEA, CA125, or CA199 levels before operation, and 71 cases (86.6 %) had postoperative TM levels reduced or returned to normal. As serum CEA, CA125, and CA199 levels could reflect tumor invasiveness [ 31 ], peritoneal free tumor cells in the ascites [ 32 ], and proliferative activity of tumor cells in ascites or primary tumor [ 33 ], respectively, the reduction of these TM could provide direct evidence that CRS + HIPEC is effective to control PC.…”

Section: Discussionmentioning

confidence: 99%

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel improves survival for patients with peritoneal carcinomatosis from abdominal and pelvic malignancies

Yang

Huang

et al. 2016

World J Surg Onc

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BackgroundThis work was to evaluate the perioperative safety and efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) with lobaplatin and docetaxel in patients with peritoneal carcinomatosis (PC) from gastrointestinal and gynecological cancers.MethodsPatients were treated by CRS + HIPEC with lobaplatin 50 mg/m2 and docetaxel 60 mg/m2 in 6000 mL of normal saline at 43 ± 0.5 °C for 60 min. Vital signs were recorded for 6 days after CRS + HIPEC procedures. Perioperative serious adverse events (SAE), hematological, hepatic, renal, and electrolytes parameters, the changes in serum tumor markers (TM) before and after operation, patient recovery, and overall survival (OS) were analyzed.ResultsOne hundred consecutive PC patients underwent 105 CRS + HIPEC procedures and postoperative chemotherapy. The median CRS + HIPEC duration was 463 (range, 245–820) min, and the highest temperature and heart rate during six postoperative days were 38.6 °C (median 37.5 °C) and 124 bpm (median 100 bpm), respectively. The 30-day perioperative SAE occurred in 16 (15.2 %) and mortality occurred in 2 (1.9 %) patients. Most routine blood laboratory tests at 1 week after surgery turned normal. Among 82 cases with increased preoperative TM CEA, CA125, and CA199, 71 cases had TM levels reduced or turned normal. Median time to nasogastric tube removal was 5 (range, 3–23) days, to liquid food intake 6 (range, 4–24) days, and to abdominal suture removal 15 (range, 10–30) days. At the median follow-up of 19.7 (range, 7.5–89.2) months, the median OS was 24.2 (95 % CI, 15.0–33.4) months, and the 1-, 3-, and 5-year OS rates were 77.5, 32.5, and 19.8 %, respectively. Univariate analysis identified five independent prognostic factors on OS: the origin of PC, peritoneal cancer index, completeness of CRS, cycles of adjuvant chemotherapy, and SAE.ConclusionsCRS + HIPEC with lobaplatin and docetaxel to treat PC is a feasible procedure with acceptable safety and can prolong the survival in selected patients with PC.Trial registrationClinicalTrials.gov, NCT00454519

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Preoperative Serum Tumor Marker Levels in Gastric Cancer

Cited by 15 publications

References 0 publications

Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

CA125 as a Marker of Heart Failure in the Older Women: A Population-Based Analysis

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy with lobaplatin and docetaxel improves survival for patients with peritoneal carcinomatosis from abdominal and pelvic malignancies

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