Preoperative systemic immune-inflammation index and prognostic nutritional index predict prognosis of patients with pulmonary neuroendocrine tumors after surgical resection

He, Huayu; Guo, Wei; Song, Peng; Liu, Lei; Zhang, Guochao; Wang, Yalong; Qiu, Bin; Tan, Fengwei; Qin, Xue; Gao, Shugeng

doi:10.21037/atm-19-4476

Cited by 23 publications

(17 citation statements)

References 48 publications

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“…However, updated international guidelines recommend using the eighth TNM staging system (8,9,24) since it is the most important prognostic parameter after histological grade (12). Several recent studies support the present findings, indicating the prognostic value of TNM staging (42,43).…”

Section: Univariate Analysissupporting

confidence: 82%

Platin‑based chemotherapy does not improve survival in patients with non‑metastatic resected typical carcinoid tumors

et al. 2022

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Chemotherapy is controversial in non-metastatic typical carcinoid (TC) tumors. Therefore, it was aimed to evaluate the impact of platin-based chemotherapy on the survival of patients with lung TC. The medical records of patients who underwent surgical resection for non-metastatic TC from 2002 to 2020 at our institution were retrospectively reviewed. Multivariate regression analysis was performed for chemotherapy and prognostic factors in disease-free survival (DFS) in 72 patients. The pathological stages of patients were as follows: 73.6% of the patients were in stage I, 15.3% in stage II and 11.1% in stage III. A total of 5 patients (6.9%) received platin-based chemotherapy and 6 patients (8.3%) had recurrences. The DFS rates at 12, 36 and 60 months were 98.5, 95.1 and 92.5%, respectively. Log-rank testing showed that patients who received chemotherapy and had stage III disease had shorter DFS (P=0.021 for chemotherapy and P<0.001 for stage). However, multivariate analysis revealed that the pathological stage was the only statistically significant factor affecting DFS (P=0.016). Platin-based chemotherapy did not improve DFS, and the eighth edition of TNM (tumor, nodes, metastases) staging did have prognostic value for patients with non-metastatic TC. Although resection has satisfying long-term outcomes, studies on new agents are needed to decrease the recurrence rate, particularly in patients with stage III disease.

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Section: Univariate Analysissupporting

confidence: 82%

Platin‑based chemotherapy does not improve survival in patients with non‑metastatic resected typical carcinoid tumors

et al. 2022

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“…The systemic immune-inflammation index (SII), which is a composite indicator integrating platelet, neutrophil and lymphocyte counts, has been proven to be a promising prognostic predictor in various diseases, including malignant tumors [ 20 – 22 ], coronary artery disease [ 23 ], acute ischemic stroke [ 24 ], and preterm premature rupture of the membranes [ 25 ]. Moreover, high SII (≥834.89) was newly identified as a good risk predictor for discriminating osteoporotic fracture risk in postmenopausal osteoporosis patients [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Systemic immune-inflammation index independently predicts poor survival of older adults with hip fracture: a prospective cohort study

et al. 2021

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Background The systemic immune-inflammation index (SII), based on peripheral platelet, neutrophil and lymphocyte counts, has been proven to be a promising prognostic indicator in various diseases. Hip fracture is a common injury among the older adults, and has become a global public health problem with high mortality and disability rates. However, the relationship between SII and the prognosis of hip fracture is not yet well-known. The aim of the this study was to explore the predictive value of SII in older adults with hip fracture undergoing surgery. Methods This was a prospective cohort study performed from January 2014 to December 2018 at a orthopaedic center, China. The SII was calculated as platelet×neutrophil/lymphocyte counts. Univariable and multivariable Cox proportional hazard models were used to assess the association between SII and all-cause mortality. Results A total of 290 older adults with hip fracture were included, and the mean (SD) age was 77.6 (8.6) years, and 189 (65.2%) were female. The median (IQR) SII was 759.4 (519.0–1128.7) × 109/L. After a median follow-up time of 33.4 months, 13 (4.5%), 26 (9.0%) and 54 (18.6%) patients died within the 30-day, 1-year and last follow-up, respectively. Multivariable Cox analysis revealed that each increase of 100 units of SII was associated with a 8% increased hazard of death at 1-year follow-up (HR = 1.08, 95% CI: 1.01–1.17, p = 0.033), and 9% increased hazard of death at last follow-up (HR = 1.09, 95% CI: 1.03–1.15, p = 0.003). Conclusions SII is associated with poor all-cause mortality in older adults with hip fracture undergoing surgery, and deserves further investigation and application in clinical practice.

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“…Based on the above findings, several nutrition-based scores have been identified in recent years as possible prognostic markers for various cancers, and the details of these scores are readily available from peripheral blood samples (18,19). Among them, the neutrophil lymphocyte ratio (NLR) and prognostic nutritional index (PNI) were considered to be independent prognostic factors that affect the survival of many malignancies (20)(21)(22)(23), and the Controlled Nutritional Status (CONUT) score, as an immune nutritional status scoring system that emerged in 2005, also took serum cholesterol into account when assessing the immune nutritional status of patients compared to PNI and NLR (24,25). The CONUT score, which is comprised of the serum values of albumin (ALB), total lymphocyte count (TLC), and total cholesterol, is considered to be a prognostic factor for postoperative prognosis of malignant tumors such as carcinoma of colon, non-small cell lung cancer, liver cancer and pancreatic ductal adenocarcinoma (26)(27)(28)(29), and has also been reported to be an important prognostic factor for survival in nonresectable HCCA (30).…”

Section: Introductionmentioning

confidence: 99%

Controlling Nutritional Status (CONUT) Score as a New Indicator of Prognosis in Patients With Hilar Cholangiocarcinoma Is Superior to NLR and PNI: A Single-Center Retrospective Study

Wang

Peng

et al. 2021

Front. Oncol.

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BackgroundCurrently, many nutritional indicators, including controlling nutritional status score (CONUT), can be used to assess a patient’s nutritional status and have been reported as reliable predictors of multiple malignancies. However, the value of CONUT score in predicting postoperative outcomes in patients with hilar cholangiocarcinoma has not been explored. In this study, its predictive value will be discussed and compared with the known predictors the neutrophil lymphocyte ratio (NLR) and prognostic nutritional index (PNI).MethodsPreoperative CONUT scores, PNI and NLR levels of 94 Hilar cholangiocarcinoma (HCCA) patients who underwent radical-intent resection of hepatobiliary surgery in our hospital from March 2010 to April 2019 were retrospectively collected and analyzed. They were grouped according to their optimal cutoff value and the prognostic effects of patients in each group were compared respectively.ResultsCONUThigh was more frequent in patients with Clavien–Dindo classification of ≥IIIa (P = 0.008) and Bile leakage presence (P = 0.011). Kaplan-Meier curves analyzing the relationship between CONUT, PNI, and NLR values and HCCA patient survival (including total survival (OS) and recurrence-free survival (RFS) showed significant differences between groups (P <0.001). Meanwhile, multi-factor analysis found that Degree of cure, PNI, NLR, and preoperative CONUT score were independent prognostic factors for OS and RFS. The predictive power of CONUT score was higher than that of NLR and PNI based on time-dependent receiver operating Characteristic (ROC) analysis and the net reclassification index (NRI) and integrated discriminatory index (IDI) values (P < 0.05).ConclusionCONUT score may be of some clinical reference value in evaluating postoperative prognosis of HCCA patients.

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Preoperative systemic immune-inflammation index and prognostic nutritional index predict prognosis of patients with pulmonary neuroendocrine tumors after surgical resection

Cited by 23 publications

References 48 publications

Platin‑based chemotherapy does not improve survival in patients with non‑metastatic resected typical carcinoid tumors

Platin‑based chemotherapy does not improve survival in patients with non‑metastatic resected typical carcinoid tumors

Systemic immune-inflammation index independently predicts poor survival of older adults with hip fracture: a prospective cohort study

Controlling Nutritional Status (CONUT) Score as a New Indicator of Prognosis in Patients With Hilar Cholangiocarcinoma Is Superior to NLR and PNI: A Single-Center Retrospective Study

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