Preoperative work-up for definition of lymph node risk involvement in early stage endometrial cancer: 5-year follow-up

Cignini, Pietro; Vitale, Salvatore Giovanni; Laganà, Antonio Simone; Biondi, Antonio; Rosa, Valentina Lucia La; Cutillo, Giuseppe

doi:10.1007/s13304-017-0418-z

Cited by 71 publications

(43 citation statements)

References 49 publications

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“…Although the survival rate of patients is relatively high if EC is diagnosed in early stages, it can be very lethal and recur frequently after surgery when it develops into advanced stages. For the preoperative evaluation or clinical management of EC, the magnetic resonance imaging (MRI) and hysteroscopic excisional biopsy (HEB) were employed usually, and combining MRI and HEB could elevate the accuracy in identifying low-risk patients [39]. Besides, the laparoscopy might also become a useful method to manage early stage EC, in which it exhibited advantageous in operative morbidity and hospital stay over laparotomy [40].…”

Section: Discussionmentioning

confidence: 99%

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

Fang¹,

Wang²,

Li³

et al. 2019

Bioscience Reports

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Endometrial cancer (EC) is one of the most common cancers in females. Although the diagnosis and treatment in early stages can greatly improve the survival rate of patients, the advanced EC still is lethal. Radiotherapy is widely used against EC, and it is a great challenge to find an effective way to overcome the resistance of EC during radiotherapy. α-bisabolol is a promising drug, which has already exhibited its anti-tumor effect in some malignancies. Here we reported that α-bisabolol could inhibit the proliferation of EC cells. It is also shown that their abilities of migration and invasion were effectively reduced by α-bisabolol. Furthermore, our results also demonstrated that α-bisabolol could improve sensitivity of EC cells in radiotherapy and further inhibited the growth of EC cells. By Western blot, we found the expression of matrix metalloproteinases-9 (MMP-9) and cyclin E were significantly decreased, which indicated that EC cells can be further suppressed by using α-bisabolol and radiotherapy. It is also demonstrated in our study that the rate of apoptotic cells is markedly increased in EC by using these two treatments. The significant decrease in X-linked inhibitor of apoptosis protein (XIAP) and increase in caspase-3 detected in our study suggested that the enhancement of apoptosis is mediated by XIAP/caspase-3 pathway, which was further confirmed by examining the downstream effectors of caspase-3, COX-2, PARP and cleaved PARP. In the present study, we demonstrated that α-bisabolol could enhance the sensitivity of EC cells to radiotherapy, which provide a novel alternative for overcoming radioresistance of EC cells and achieving a better outcome in radiotherapy.

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Section: Discussionmentioning

confidence: 99%

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

Fang¹,

Wang²,

Li³

et al. 2019

Bioscience Reports

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“…At the same time, pre-menopausal women may choose conservative management to preserve their fertility. Advances in pre-operative staging will enable more women with low-risk disease to be accurately identified for non-surgical management [36,37]. Therefore, the proportion of women receiving LNG-IUS therapy for AH/Stage 1a EEC is likely to increase.…”

Section: Discussionmentioning

confidence: 99%

Baseline Serum HE4 But Not Tissue HE4 Expression Predicts Response to the Levonorgestrel-Releasing Intrauterine System in Atypical Hyperplasia and Early Stage Endometrial Cancer

Behrouzi

Ryan

Barr

et al. 2020

Cancers

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The levonorgestrel-releasing intrauterine system (LNG-IUS) is a conservative management option for atypical hyperplasia (AH) and low grade early stage endometrial cancer (EEC), but around 1 in 3 patients fail to respond to treatment. The aim of this study was to investigate if serum and/or tissue HE4 expression could predict response to LNG-IUS therapy. Patients with AH or presumed Stage I EEC had serum and endometrial samples taken at baseline and at 3-month intervals over 12 months post-insertion of LNG-IUS. 74 patients were recruited and baseline demographics recorded. Of 57 patients for whom response was histologically determinable, 39 (68%) were responders and 18 (32%) non-responders. Mean baseline serum HE4 was significantly lower in responders (62.1 ± 1.1 pM, 95% confidence interval (CI) 52.7–73.2), compared to non-responders (125.6 ± 1.3 pM, 95% CI 74.5–211.7, p = 0.014), including when considering age, BMI, menopausal status, smoking status, and histological grade as covariables (p = 0.005). Baseline tissue HE4 expression was not significantly different in responders compared to non-responders (p = 0.999). Responders showed a significant mean reduction (−9.8 ± 3.4%, 95% CI −16.7 to −2.8%, p = 0.008) in serum HE4 between baseline and 3 months (p = 0.008), whereas non-responders showed no significant change (p = 0.676). Neither responders nor non-responders showed a significant percentage change in serum HE4 from baseline beyond 3 months (p > 0.05). Change in serum HE4 between baseline and 3 and 6 months and tissue HE4 tissue expression between baseline and 3, 6, and 12 months was not significantly different in responders compared to non-responders (p > 0.05). This study suggests that baseline serum HE4, but not baseline tissue HE4 expression, is independently predictive of response to the LNG-IUS and could be used to guide management decisions.

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“…However, we did not assess previous gynecological cancer history as part of our data collection. Previous studies have discussed the association between gynecological cancers and breast cancer …”

Section: Discussionmentioning

confidence: 99%

Benign breast papilloma: Is surgical excision necessary?

et al. 2019

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Preoperative work-up for definition of lymph node risk involvement in early stage endometrial cancer: 5-year follow-up

Cited by 71 publications

References 49 publications

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

α-bisabolol enhances radiotherapy-induced apoptosis in endometrial cancer cells by reducing the effect of XIAP on inhibiting caspase-3

Baseline Serum HE4 But Not Tissue HE4 Expression Predicts Response to the Levonorgestrel-Releasing Intrauterine System in Atypical Hyperplasia and Early Stage Endometrial Cancer

Benign breast papilloma: Is surgical excision necessary?

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