Preparation and adsorption property of aminated cross linking microbeads of GMA/EGDMA for bilirubin

Abstract

Cross linking microbeads with a controllable diameter were synthesized by suspension copolymerization of the monomer glycidyl methacrylate (GMA) and the cross linking agent ethylene glycol dimethylacrylate (EGDMA). By the ring-opening reaction of the epoxy groups, the microbeads GMA/EGDMA were modified with different aminating agents and resulting in the aminated microbeads. The morphology of the microbeads was characterized by SEM. The adsorption property of aminated microbeads for bilirubin was investigated, and the effects of various factors, such as the chemical structures of the aminating agents, pH values of the medium and the presence of bovine serum albumin in the adsorption medium, on the adsorption property were examined. The experimental results show that the aminated microbeads have strong adsorption ability for bilirubin, and the isotherm adsorption behaviour is fitted to Freundlich equation satisfactorily. The adsorption ability of the aminated microbeads modified with hexanediamine is stronger than that of others, and the longer the molecule of multi-ethylene multiamine, the weaker the adsorption ability for bilirubin. The pH value of the medium affects the adsorption ability greatly, as pH = 6, the adsorption ability is strongest. In the presence of BSA, the microbeads still have a higher adsorption capacity towards bilirubin.

Functional polyethersulfone particles for the removal of bilirubin

“…In this study, the main aim is to provide a facile and convenient method to prepare practical particles for the removal of bilirubin. The adsorbed bilirubin amounts in this study were comparable to other reports [30][31][32].…”

“…Compared with HDA, the chain of EDA was too short so the steric barrier was more serious, and the adsorption resistance thus increased. As of DETA, the chain length was similar to that of HDA, but the -N-Hgroup contributed more hydrophilic interactions [32]. The diameter of the particles also affected the adsorption capacity, as shown in Fig.…”

Electrospun fluorescein-embedded nanofibers towards fingerprint recognition and luminescent patterns

“…7c). As we know, PGMA is easy to be functionalized because of the reactive epoxy groups and PLA is likely to cross-link due to its reactive groups, [33][34][35][36][37] especially with the carboxyl, hydroxy and amino function groups, which can be supplied by the residues of the fingerprints.…”

Non-ionic macroporous polystyrene adsorbents for removal of serum toxins in liver failure by hemoperfusion

“…Adsorption technology is often used to remove proteinbound toxins. Many adsorbents that form the core of the extracorporeal detoxification systems have already been developed, such as activated carbon (Annesini et al 2008, Chirito et al 1977, copolymer of styrene and divinylbenzene, and anion exchange resins (Chen et al 2009, Jia et al 2005, Piemonte et al 2010, Yu 2013. Bilirubin is a negatively charged pigment with carboxyl groups linked to the molecule (Figure 1) (Odell 1959, Stocker et al 1987.…”