Preparation and antibacterial activity of oligosaccharides derived from dandelion

Li, Qian; Zhou, Yan; Teng, Zhaolin; Du, Chunling; Tian, Changrong

doi:10.1016/j.ijbiomac.2013.12.031

Cited by 42 publications

(15 citation statements)

References 5 publications

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“…Researchers have attempted to isolate compounds from Taraxacum that have activity against food‐borne pathogens and thus possible applications in food systems. Oligosaccharides isolated from Taraxacum referred to as dandelion‐derived oligosaccharides (DOs) were evaluated for activity against Bacillus subtilis , Staphylococcus aureus , and Escherichia coli (Qian, Zhou, Teng, Du, & Tian, ). The diameter of the zone of inhibition by DOs ranged from 12.04 to 16.15 mm for the latter bacteria (100 mg/ml), indicating that DOs had high antibacterial activity.…”

Section: The Genus Taraxacum As a Food Preservativementioning

confidence: 99%

Ethnobotany of the genus Taraxacum—Phytochemicals and antimicrobial activity

Sharifi‐Rad

Roberts

Matthews

et al. 2018

Phytotherapy Research

108

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Plants belonging to the genus Taraxacum have been used in traditional healthcare to treat infectious diseases including food-borne infections. This review aims to summarize the available information on Taraxacum spp., focusing on plant cultivation, ethnomedicinal uses, bioactive phytochemicals, and antimicrobial properties. Phytochemicals present in Taraxacum spp. include sesquiterpene lactones, such as taraxacin, mongolicumin B, and taraxinic acid derivatives; triterpenoids, such as taraxasterol, taraxerol, and officinatrione; and phenolic derivatives, such as hydroxycinnamic acids (chlorogenic, chicoric, and caffeoyltartaric acids), coumarins (aesculin and cichoriin), lignans (mongolicumin A), and taraxacosides. Aqueous and organic extracts of different plant parts exhibit promising in vitro antimicrobial activity relevant for controlling fungi and Gram-positive and Gram-negative bacteria. Therefore, this genus represents a potential source of bioactive phytochemicals with broad-spectrum antimicrobial activity. However, so far, preclinical evidence for these activities has not been fully substantiated by clinical studies. Indeed, clinical evidence for the activity of Taraxacum bioactive compounds is still scant, at least for infectious diseases, and there is limited information on oral bioavailability, pharmacological activities, and safety of Taraxacum products in humans, though their traditional uses would suggest that these plants are safe.

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Section: The Genus Taraxacum As a Food Preservativementioning

confidence: 99%

Ethnobotany of the genus Taraxacum—Phytochemicals and antimicrobial activity

Sharifi‐Rad

Roberts

Matthews

et al. 2018

Phytotherapy Research

108

View full text Add to dashboard Cite

show abstract

“… 8 TH, commonly known as dandelions, are traditionally used for anti-inflammatory and diuretic effect. According to recent reports, 9 – 13 TH may be effective at liver cancer, breast cancer or uterine cancer and also had antioxidant activities by inhibiting of process of nitric oxide and prostaglandin E2. 14 , 15 Inflammatory mediators can regulate tissue regeneration, but its continual activation has been associated with carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Heme Oxygenase-1 Induction and Anti-inflammatory Actions ofAtractylodes macrocephalaandTaraxacum herbaExtracts Prevented Colitis and Was More Effective than Sulfasalazine in Preventing Relapse

et al. 2017

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Background/AimsIn inflammatory bowel disease (IBD), repeated bouts of remission and relapse occur in patients and can impose a risk of colitis-associated cancer. We hypothesized that plant extracts of Atractylodes macrocephala (AM) or Taraxacum herba (TH) may be better than sulfasalazine for treating this disease because these extracts can promote additional regeneration.MethodsMurine intestinal epithelial IEC-6 cells were pretreated with AM or TH before a lipopolysaccharide (LPS)-induced challenge. Acute colitis was induced with 7 days of dextran sulfate sodium (DSS) in male C57BL/6 mice, and extracts of AM and TH were administered for 2 weeks before DSS administration.ResultsIn vitro studies demonstrated that AM or TH treatment reduced LPS-induced COX-2 and tumor necrosis factor-α mRNA levels but increased heme oxygenase-1 (HO-1). Oral preadministration of AM and TH rescued mice from DSS-induced colitis by inhibiting inflammatory mediators via inactivated extracellular signal regulated kinase and repressed nuclear factor κB and signal transducer and activator of transcription 3, but the effect was weaker for sulfasalazine than that for the extracts. Anti-inflammatory activities occurred via the inhibition of macrophage and T lymphocyte infiltrations. Unlike sulfasalazine, which did not induce HO-1, TH extracts afforded significant HO-1 induction.ConclusionsBecause the AM or TH extracts were far superior in preventing DSS-induced colitis than sulfasalazine, AM or TH extracts can be considered natural agents that can prevent IBD relapse.

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“…Dandelion, a rich source of fructan can be exploited for generation of fructose using microbial inulinase (Kango, 2008;Qian et al, 2014;Weber & Wigg, 2014;Martinez et al, 2015;Rawat et al, 2015a;Rawat et al, 2016).…”

Section: Introductionmentioning

confidence: 99%