Preparation and Antibacterial Properties of a Composite Fiber Membrane Material Loaded with Cationic Antibacterial Agent by Electrospinning

Abstract

Microbial infections due to bacteria, viruses, and molds are a serious threat to both human life and the health of other organisms. To develop inexpensive, easy-to-prepare, efficient, and portable nano-antibacterial materials, as well as to explore the antibacterial prospects of cationic antibacterial agents, in this work, six different membrane materials were prepared by the electrostatic spinning method and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR). The materials were tested for antimicrobial properties using a modified AATCC100-200 test method. Under the most suitable spinning conditions, the doping amount of the cationic antimicrobial agent, CTAB, had the greatest influence on the antimicrobial performance. The antimicrobial performance of PCL/PEO/CS/CTAB0.4 was the highest among the prepared materials, with 83.7% effectiveness against S. aureus and 99.9% against E. coli. The antimicrobial performance was found to be stable. In our study, we determined the most suitable spinning ratio to prepare an inexpensive and efficient cationic antimicrobial agent. Biodegradable, high-antimicrobial-activity antimicrobial materials can be applied as films, and this new nanofiber material has shown great potential in wound dressings and as a mask material due to its remarkable antimicrobial efficiency.

Recent Advances in Biodegradable and Biocompatible Synthetic Polymers Used in Skin Wound Healing

“…These nanofibers have similar microstructures like the extracellular matrix which can mimic the structure and function of skin. Compared with traditional dressings, electrospun nanofibers have larger specific surface areas, ensuring the air exchange with the outside world while preventing the invasion of bacteria [34]. In addition, it is feasible to adjust parameters such as polymer composition, solution concentration, applied voltage, distance, etc., to fabricate fibers conducive to cell adhesion and proliferation [35].…”

Fabrication of innovative wound exudates dissolvable electrospun povidone-iodine loaded poly (Ɛ-caprolactone)-poly (ethylene oxide) composite nanofiber mat based wound bandages

“…The change in contact angle from 110° to 0° was due to the presence of hydrophilic pvpi and PEO within the structure of the prepared PCL-PEO composite nanofiber mats, thus making the newly developed pvpi_blended PCL-PEO composite nanofiber mats satisfactorily hydrophilic at 0°. From the literature, Li et al developed the PCL-PEO composite nanofiber membrane materials and subsequently proved their hydrophilicity behavior through contact angle measurement, which they reported to be 42.25°, thus hydrophilic due to the presence of the PEO within the membranes 35 . Generally, hydrophobic materials are characterized by contact angles above 90° whereas those showing hydrophilic behavior are characterized to have contact angles below 90° 36,37 .…”

A one-step method for generating antimicrobial nanofibre meshes via coaxial electrospinning

“…Previous studies have electrospun PCL and CTAB, primarily focusing on the development of antimicrobial nanomaterials using monoaxial electrospinning. 16,17 Other studies involved modifying the charge of PCL scaffolds to enhance their properties 18,19 and developing PCL/CTAB electrospun nanowebs as models for mass spectrometry. 20,21 In contrast, our approach utilises coaxial electrospinning to directly coat CTAB onto the surface of PCL, enabling the one-step preparation of an antimicrobial nanofibre mesh.…”