Preparation and antibacterial properties of curcumin-loaded cyclodextrin-grafted chitosan hydrogel

Hao, Pei Yan; Zhou, Hui; Ren, Li Jun; Zheng, Hui Jie; Tong, Jia Nan; Chen, Ya Wei; Park, Hyun Jin

doi:10.1007/s10971-023-06097-8

Cited by 16 publications

(2 citation statements)

References 61 publications

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“…For example, Hao PY et al ( Hao et al, 2023 ) generated a turmeric cyclodextrin-grafted chitosan hydrogel by attaching curcumin to chitosan. The antimicrobial activity of the hydrogel against Staphylococcus aureus and Escherichia coli was found by antibacterial assay, which could be attributed to the electrostatic interactions between –NH 3 + in the hydrogel and the negatively charged bacterial cells, thus inhibiting the growth and even death of the microorganisms.…”

Section: Bioactivity Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Chitosan-based hydrogels: From preparation to applications, a review

Hong,

Qiu,

Wang

et al. 2024

Food Chemistry: X

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Section: Bioactivity Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Chitosan-based hydrogels: From preparation to applications, a review

Hong,

Qiu,

Wang

et al. 2024

Food Chemistry: X

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“…Synthetic PVA hydrogels have also been tested by loading them with Calendula officinalis extract, which improves the adhesiveness and was effective against both Gram-positive and Gram-negative bacteria [ 103 ]. Curcumin, obtained from the roots of Curcuma longa, is a hydrophobic polyphenolic compound with remarkable bioactive properties, and promising results have been obtained by loading it into chitosan or PVA hydrogels [ 104 , 105 , 106 , 107 ]. Some essential oils are derived from plants such as lavender, thyme, peppermint, tea tree, rosemary, cinnamon, eucalyptus, and lemongrass [ 108 ].…”

Section: Classification Of Antimicrobial Hydrogelsmentioning

confidence: 99%

Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications

Ortega,

De Leon-Oliva,

Boaru

et al. 2023

Gels

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The growing impact of infections and the rapid emergence of antibiotic resistance represent a public health concern worldwide. The exponential development in the field of biomaterials and its multiple applications can offer a solution to the problems that derive from these situations. In this sense, antimicrobial hydrogels represent a promising opportunity with multiple translational expectations in the medical management of infectious diseases due to their unique physicochemical and biological properties as well as for drug delivery in specific areas. Hydrogels are three-dimensional cross-linked networks of hydrophilic polymers that can absorb and retain large amounts of water or biological fluids. Moreover, antimicrobial hydrogels (AMH) present good biocompatibility, low toxicity, availability, viscoelasticity, biodegradability, and antimicrobial properties. In the present review, we collect and discuss the most promising strategies in the development of AMH, which are divided into hydrogels with inherent antimicrobial activity and antimicrobial agent-loaded hydrogels based on their composition. Then, we present an overview of the main translational applications: wound healing, tissue engineering and regeneration, drug delivery systems, contact lenses, 3D printing, biosensing, and water purification.

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A 3D bioprinted antibacterial hydrogel dressing of gelatin/sodium alginate loaded with ciprofloxacin hydrochloride

Cao,

Lu,

Chen

et al. 2024

Biotechnology Journal

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Skin plays a crucial role in human physiological functions, however, it was vulnerable to bacterial infection which delayed wound healing. Nowadays, designing an individual wound dressing with good biocompatibility and sustaining anti‐infection capability for healing of chronic wounds are still challenging. In this study, various concentrations of the ciprofloxacin (CIP) were mixed with gelatine (Gel)/sodium alginate (SA) solution to prepare Gel/SA/CIP (GAC) bioinks, following the fabrication of GAC scaffold by an extrusion 3D bioprinting technology. The results showed that the GAC bioinks had good printability and the printed GAC scaffolds double‐crosslinked by EDC/NHS and CaCl2 had rich porous structure with appropriate pore size, which were conducive to drug release and cell growth. It demonstrated that the CIP could be rapidly released by 70% in 5 min, which endowed the GAC composite scaffolds with an excellent antibacterial ability. Especially, the antibacterial activities of GAC7.5 against Escherichia coli and Staphylococcus aureus within 24 h were even close to 100%, and the inhibition zones were still maintained 14.78 ± 0.40 mm and 14.78 ± 0.40 mm, respectively, after 24 h. Meanwhile, GAC7.5 also demonstrated impressive biocompatibility which can promote the growth and migration of L929 and accelerate wound healing. Overall, the GAC7.5 3D bioprinting scaffold could be used as a potential skin dressing for susceptible wounds with excellent antibacterial activity and good biocompatibility to meet urgent clinical needs.

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Preparation and antibacterial properties of curcumin-loaded cyclodextrin-grafted chitosan hydrogel

Cited by 16 publications

References 61 publications

Chitosan-based hydrogels: From preparation to applications, a review

Chitosan-based hydrogels: From preparation to applications, a review

Unraveling the New Perspectives on Antimicrobial Hydrogels: State-of-the-Art and Translational Applications

A 3D bioprinted antibacterial hydrogel dressing of gelatin/sodium alginate loaded with ciprofloxacin hydrochloride

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