Preparation and application of Janus nanoparticles: Recent development and prospects

Li, Xiaoshuang; Chen, Ligang; Cui, Di; Jiang, Wei; Han, Lixia; Niu, Na

doi:10.1016/j.ccr.2021.214318

Cited by 65 publications

(29 citation statements)

References 169 publications

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“…Janus particles are the simplest type of patchy particles, as they present only two distinguishable phases of equal amounts of surface anisotropy. − Since solid-state NMR requires a significant quantity of material (>30 mg), some of the routes to produce Janus NPs, such as certain masking methods like vapor deposition, are not practical . One way to prepare larger quantities of Janus NPs is through Pickering emulsions, where the NPs accumulate at the interface of immiscible liquids (oil and water), lower the total free energy, and stabilize the droplets against coalescence.…”

Section: Resultsmentioning

confidence: 99%

“…35−38 Since solid-state NMR requires a significant quantity of material (>30 mg), some of the routes to produce Janus NPs, such as certain masking methods like vapor deposition, are not practical. 39 One way to prepare larger quantities of Janus NPs is through Pickering emulsions, where the NPs accumulate at the interface of immiscible liquids (oil and water), lower the total free energy, and stabilize the droplets against coalescence. This allows the water-exposed region to be chemically modified.…”

Section: Nanoparticles With Mixed Ligand Shells (Mls Nps)mentioning

confidence: 99%

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NMR Characterization of Nanoscale Surface Patterning in Mixed Ligand Nanoparticles

2022

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Spontaneous phase separation in binary mixed ligand shells is a proposed strategy to create patchy nanoparticles. The surface anisotropy, providing directionality along with interfacial properties emerging from both ligands, is highly desirable for targeted drug delivery, catalysis, and other applications. However, characterization of phase separation on the nanoscale remains quite challenging. Here we have adapted solid-state 1 H spin diffusion NMR experiments designed to detect and quantify spatial heterogeneity in polymeric materials to nanoparticles (NPs) functionalized with mixed short ligands. Janus NPs and physical mixtures of homoligand 3.5 nm diameter ZrO 2 NPs, with aromatic (phenylphosphonic acid, PPA) and aliphatic (oleic acid, OA) ligands, were used to calibrate the 1 H spin diffusion experiments. The Janus NPs, prepared by a facile wax/water Pickering emulsion method, and mixed ligand NPs, produced by ligand exchange, both with 1:1 PPA:OA ligand compositions, display strikingly different solvent and particle−particle interactions. 1 H spin diffusion NMR experiments are most consistent with a lamellar surface pattern for the mixed ligand ZrO 2 NPs. Solid-state 1 H spin diffusion NMR is shown to be a valuable additional characterization tool for mixed ligand NPs, as it not only detects the presence of nanoscale phase separation but also allows measurement of the domain sizes and geometries of the surface phase separation.

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Section: Resultsmentioning

confidence: 99%

Section: Nanoparticles With Mixed Ligand Shells (Mls Nps)mentioning

confidence: 99%

NMR Characterization of Nanoscale Surface Patterning in Mixed Ligand Nanoparticles

2022

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“…Due to the different physical and chemical properties of JPs, different reactions can occur on both sides of asymmetric JPs, producing unequal propulsion force so that the nanoparticles have a particular direction of propulsion force [ 14 , 15 , 16 , 17 ]. JPs provide a new idea for the movement of particles and have been widely used as drug carriers [ 18 , 19 , 20 ] and to build biosensors [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Janus Particles in Point-of-Care Testing

et al. 2022

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Janus particles (JPs), named after the two-faced Roman god, are asymmetric particles with different chemical properties or polarities. JPs have been widely used in the biomedical field in recent years, including as drug carriers for targeted controlled drug release and as biosensors for biological imaging and biomarker detection, which is crucial in the early detection and treatment of diseases. In this review, we highlight the most recent advancements made with regard to Janus particles in point-of-care testing (POCT). Firstly, we introduce several commonly used methods for preparing Janus particles. Secondly, we present biomarker detection using JPs based on various detection methods to achieve the goal of POCT. Finally, we discuss the challenges and opportunities for developing Janus particles in POCT. This review will facilitate the development of POCT biosensing devices based on the unique properties of Janus particles.

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“…Based on the above merits of JNPs, much effort has been spent in this field in the past decade, which has been partially covered by some review papers. [5][6][7][8][9] However, there is still no specific review paper that focus on the bioimaging strategies based on JNPs. Bearing it in mind and considering the current challenges, this paper focuses on the discussion of JNPs orchestrated in the field of biological imaging.…”

Section: Introductionmentioning

confidence: 99%