Preparation and application of molecularly imprinted polymer for isolation of chicoric acid from Chicorium intybus L. medicinal plant

Molecularly Imprinted Polymers for Selective Extraction of Oblongifolin C from <em>Garcinia yunnanensis</em> Hu

“…We found that the rough and irregular particles of both polymers were constructed as network structures, which was mainly due to using the bulk polymerization method. However, such irregularity in our study did not have a significant effect on the binding properties of the imprinted polymer, as previously reported for bulk polymers [34]. The morphology of the best polymer was further investigated using BET N2 adsorption-desorption analysis.…”

“…Moreover, the bond distances between the hydrogen atom of the OH-group or NH2-group and the oxygen atom of the carbonyl group at the different sites were calculated. They all ranged between 1.66 and 2.39 Å which is within the hydrogen bond range as indicated in Figure 2 [34,35]. Thus, hydrogen bonding is the only possible contributor in the stabilization of the pre-polymerization complex [36].…”

“…The obtained results showed that the calculated binding energies decreased by increasing the number of monomers used, and the lower the value of the binding energy, the more stable the formation of the complex. Thus, the best molar ratio for polymer preparation was 1:4, providing the MIPs with good recognition properties [33,34]. Figure 2 represented the best conformations of OC, AM and the 1:4 complex.…”

“…Over the past decades, these polymers have been successfully used in different fields [10][11][12][13][14][15] such as chemical sensors [16][17][18][19][20], enzyme mimicking catalysis [21][22][23], intelligent drug delivery [24][25][26][27], etc. In particular, MIPs have been extensively employed as the adsorbents of the solid phase extraction (SPE) for the selective extraction of a target compound and structural analogues from the complex matrices, such as natural products [28][29][30][31][32]. However, little paper could focus on the isolation of structural analogues with the same polar functional groups and a similar molecular volume from the complex matrices only by molecularly imprinted solid-phase extraction (MISPE) technique.…”

Isolation of sinapic acid from broccoli using molecularly imprinted polymers

“…These results were expected due to the basic nature of 4‐VP, which enhanced its binding to acidic templates . Also, it was found from previous studies that 4‐VP could be successfully used as a functional monomer for other phenolic acids as chicoric acid , caffeic acid , cinnamic acid, and ferulic acid .…”