Preparation and Bioavailability Evaluation of Micronized Steroidal Mecigestone Drug Substance

Nazarov, A. K.; Заварзин, И. В.; Nazarov, G. V.; Aksenov, A. V.; Левина, И. С.

doi:10.1007/s11094-016-1357-6

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…indomethacin/anti-inflammatory, 85 . mecigestone/steroidal hormone, 153 . nicergoline/vasodilator, 154 or .…”

Section: Direct Transformation Of Pure Poorly Water-soluble Drugsmentioning

confidence: 99%

“…154 Nazarov et al demonstrated that nano spray-dried mecigestone was 7.5 times more bioavailable after oral administration to rats than the crystalline starting drug of 200 mm. 153 Durli et al showed that the addition of surfactants enabled an increase in process yield, more than 90% of nano spray-dried dexamethasone particles were in the submicron range. 58…”

Section: Direct Transformation Of Pure Poorly Water-soluble Drugsmentioning

confidence: 99%

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Nano Spray-Dried Drugs for Oral Administration: A Review

Öztürk

Arpagaus

2021

ASSAY and Drug Development Technologies

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Spray drying is an important technology that is fast, simple, reproducible, and scalable. It has a wide application range, that is, in food, chemicals, and encapsulation of pharmaceuticals. The technology can be divided into conventional spray drying and nano spray drying. The key advantage of nano spray drying is the production of drug-loaded nanosized particles for various drug delivery applications. The recent developments in nano spray dryer technology and the market launch of the Nano Spray Dryer B-90 by Bu ¨chi Labortechnik AG in 2009 enabled the production of submicron spray-dried particles. This review focuses on nanosized drug delivery systems intended for oral administration produced by nano spray drying. First, the nano spray drying concept, the basic technologies implemented in the equipment, and the effects of the various process parameters on the final dry submicron powder properties are presented. Then, the topics of new formulation strategies of oral drugs are highlighted with examples that have entered the research literature in recent years. Next, the subjects of direct conversion of poorly watersoluble drugs, encapsulation of drugs, and drying of preformed nanoparticles are considered. Finally, topics such as morphology, particle size, size distribution, surface analysis, bioavailability, drug release, release kinetics, and solid-state characterization (by differential scanning calorimetry, X-ray diffraction, Fourier transform infrared spectroscopy, nuclear magnetic resonance) of oral drug delivery systems produced by nano spray drying are discussed. The review attempts to provide a comprehensive knowledge base with current literature and foresight to researchers working in the field of pharmaceutical technology and nanotechnology and especially in the field of nano spray drying.

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“…indomethacin/anti-inflammatory, 85 . mecigestone/steroidal hormone, 153 . nicergoline/vasodilator, 154 or .…”

Section: Direct Transformation Of Pure Poorly Water-soluble Drugsmentioning

confidence: 99%

Section: Direct Transformation Of Pure Poorly Water-soluble Drugsmentioning

confidence: 99%

Nano Spray-Dried Drugs for Oral Administration: A Review

Öztürk

Arpagaus

2021

ASSAY and Drug Development Technologies

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“…• oral (e.g. poorly water-soluble drugs like diuretic furosemide [10], pain reducing nimesulide [100], blood vessels dilating nicergoline [67], fever reducing indomethacin [99], anti-inflammatory dexamethasone [46], or steroidal hormone mecigestone [109]),…”

Section: Applications Of Nano Spray Dried Pharmaceuticals On the Labomentioning

confidence: 99%

Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Arpagaus¹

2018

Int J Med Nano Res

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Spray drying plays a crucial role in the processing of pharmaceutical products such as pills, capsules, and tablets as it is used to convert drug-containing liquids into dried powdered forms. Nano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and delivering the drugs to the right place and time in the body. The nano spray dryer developed in the recent years extends the spectrum of produced powder particles to the submicron-and nanoscale with very narrow size distributions and sample quantities in the milligram scale at high product yields. This enables the economical use of expensive active pharmaceutical ingredients and pure drugs. The present paper explains the concept of nano spray drying in the laboratory-scale and discusses the influence of the main process parameters on the final powder properties like particle size, morphology, encapsulation efficiency, and drug loading. Application results of nano spray drying for the formulation and encapsulation of different drugs are reviewed.

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