Preparation and biodistribution of 99mTc-tricarbonyl complex with 4-[(2-methoxyphenyl)piperazin-1-yl]-dithioformate as a potential 5-HT1A receptor imaging agent

Synthesis and Preliminary Evaluation of 18F-Labeled Pyridaben Analogues for Myocardial Perfusion Imaging with PET

“…After calculation of the net radioactivity intensity, about 74% and 62% of the radioactivity were found to have been blocked by rotenone and 19 F-FP1OP, respectively. The results of autoradiography suggest that 19 F-FP1OP has the same binding site as, and comparable affinity to, rotenone. This is potent evidence that the 18 F-FP1OP was taken up by myocardium through the MC-I enzyme and remained in mitochondria.…”

“…2A and 2C). The delayed retention time of 19 F-FP1OP indicated that the compound with the shorter radiolabeling chain has lower polarity and hydrophilicity. Their chemical purity was calculated as more than 98% from the HPLC chromatogram (l 5 254 nm), suggesting they are acceptable reference standards for the corresponding radioactive tracers.…”

“…They then were kept fasting overnight (12 h) and weighed before treatment (22). A group of 5 male and 5 female mice was treated with each dose level of nonradioactive 19 F-FP1OP (1.0142, 1.1064, 1.2171, 1.3830, and 1.6043 mg/kg) or saline through tail vein injection. The mice were observed for 7 d after injection, and mortality was recorded.…”

“…A previously published procedure (16,19) was used to measure the octanol-to-water partition coefficient and to perform the paper electrophoresis experiment. The partition coefficient value, expressed as log P, was measured in 1-octanol and phosphate buffer (0.025 M, pH 7.4).…”

[^99mTc(CO)₃]-Radiolabeled Bevacizumab: In vitro and in vivo Evaluation in a Melanoma Model

“…In [ 99m Tc (OH 2 ) 3 (CO) 3 ] + all three water molecules are very labile with respect to substitution. Therefore, a variety of chelators can be used as bifunctional chelators for the 99m Tc-labeling of biomolecules [13,14,15,16,17,18]. …”