Preparation and biological evaluation of quinoline amines as anticancer agents and its molecular docking

Synthesis of novel benzo naphtho naphthyridines from 2,4‐dicloroquinolines

“…From the above point of observations, the final products in both cases ( 5a and 12a ) one proton gets deshielded in each case, which is shown in Figure 1. Finally, we have compared the most recently reported 24–30 catalysts and the solvent condition was shown in Table 3. The selective amination reaction involving various aromatic amines thereby deriving the respective anilino‐analogs with their reaction conditions according to their catalyst investigation based on solvent performances.…”

“…Pale yellow spongy mass; M.p: 122–124°C; (Lit 24 . M,p: 116–118°C) Yield: (43%); FT‐IR (KBr, cm −1 ) ν max : 3120 (NH), 1597 (C═N); 1 H NMR (500 MHz, CDCl 3 ) (ppm) δ H : δ 6.91 (s, 1H, C 3 ‐H), 7.21 (s, 1H, C 2 ‐NH), 7.50–7.94 (m, 8H, C 7 , C 2 ′‐C 8 ′‐H), 8.00 (d, 1H, C 5 ‐H J = 2.40 Hz), 8.04 (d, 1H, C 8 ‐H J = 8.00 Hz); 13 C NMR (125 MHz, CDCl 3 ) (ppm) δ C : 17.68, 110.01, 120.56, 121.62, 122.…”

“…A detailed survey of the literature points out that the reaction of chloroquinolines was aimed to get substituted quinolines possessing biological activity one among them is the amination reaction involving aromatic amines thereby deriving the respective anilinoquinolines. Research on the chemistry of naphthyridines has expanded considerably in recent years in connection with the fact that biologically active compounds have been detected among the derivatives of these heterocycles 20,23,24 . After viewing the above facts, the object of the present investigation was to study the reaction of 2,4‐dichlorobenzo and 2,4‐dichloroquinolines with aromatic amine derivatives through quinoline amine intermediates to get benzo naphtha naphthyridines.…”