Preparation and blood compatibility of electrospun nanofibrous CTS/PLA mats from chitosan nanopowders and poly(lactic acid)

Dong, Wenyuan; Zeng, Qinhuan; Yin, Xijie; Liu, Haifang; Lv, Ju; Zhu, Li

doi:10.1002/pc.24500

Cited by 12 publications

(6 citation statements)

References 47 publications

(62 reference statements)

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“…Electrospun PLA/chitosan nanofibres are expected to form a new biomaterial that possesses a combination of properties, which cannot be exhibited by individual polymers. During recent decades, significant progress has been made in the preparation of PLA/chitosan nanofibres [32,33,34,35,36,37,38]. The results show that the differences in nature, structure and compatibility between PLA and chitosan lead to a poor dispersion of the two phases.…”

Section: Introductionmentioning

confidence: 99%

Nanoporous PLA/(Chitosan Nanoparticle) Composite Fibrous Membranes with Excellent Air Filtration and Antibacterial Performance

Wang

Zhang

et al. 2018

Polymers

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Particulate matter (PM) pollution, which usually carries viruses and bacteria, has drawn considerable attention as a major threat to public health. In this present study, an environment-friendly antibacterial Poly(lactic acid)(PLA)/chitosan composite air filter was fabricated using the one-step electrospinning technique. The composite PLA/chitosan fibres show a highly porous structure, in which chitosan nanoparticles (NPs) were found to be uniformly distributed throughout the entire fibre. The morphologies, through-pore size and distribution, air filtration and anti-microbial properties of these filter media were studied. The results showed that it was not the chitosan content but instead the concentration of the spinning solutions that had the greatest effect on the morphologies of the porous fibres. The relative humidity influenced the nanometre-scale pores on the surface of PLA/chitosan fibres. The PLA/chitosan fibrous membranes with a chitosan to PLA mass ratio of 2.5:8 exhibited a high filtration efficiency of 98.99% and a relatively low pressure drop (147.60 Pa) when the air flow rate was 14 cm/s, while these also had high antibacterial activity of 99.4% and 99.5% against Escherichia coli and Staphylococcus aureus, respectively. It took 33 min for the PM2.5 concentration to decrease to 0 μg/m3 from 999 μg/m3 using the PLA/chitosan fibrous membranes, which demonstrates obviously effective air purification performance.

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Section: Introductionmentioning

confidence: 99%

Nanoporous PLA/(Chitosan Nanoparticle) Composite Fibrous Membranes with Excellent Air Filtration and Antibacterial Performance

Wang

Zhang

et al. 2018

Polymers

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“…The surface biocompatibility was affected by surface hydrophilicity to a certain degree [ 31 ]. The surface hydrophilicity of the SPU and SPU-CHO films were investigated by a WCA test [ 32 , 33 ], and the time dependence of WCA is exhibited in Figure 4 .…”

Section: Resultsmentioning

confidence: 99%

“…With regards to blood-contacting materials, blood compatibility is one of the most important biocompatibilities [ 31 ]. It is generally known that, when an artificial material comes into contact with blood, it results in the platelet adhesion, making the coagulation pathways active, and then facilitating thrombosis [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility

Liu

Gao

et al. 2021

Membranes

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In the paper, the chitooligosaccharide (CHO) was surface-grafted on the medical segmented poly(ester-urethane) (SPU) film by a facile two-step procedure to improve the surface biocompatibility. By chemical treatment of SPU film with hexamethylene diisocyanate under mild reaction condition, free -NCO groups were first introduced on the surface with high grafting density, which were then coupled with -NH2 groups of CHO to immobilize CHO on the SPU surface (SPU-CHO). The CHO-covered surface was characterized by FT-IR and water contact angle test. Due to the hydrophilicity of CHO, the SPU-CHO possessed higher surface hydrophilicity and faster hydrolytic degradation rate than blank SPU. The almost overlapping stress-strain curves of SPU and SPU-CHO films demonstrated that the chemical treatments had little destruction on the intrinsic properties of the substrate. In addition, the significant inhibition of platelet adhesion and protein adsorption on CHO-covered surface endowed SPU-CHO an outstanding surface biocompatibility (especially blood compatibility). These results indicated that the CHO-grafted SPU was a promising candidate as blood-contacting biomaterial for biomedical applications.

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“…3 The molecular structure of the PLA contains a large number of ester bonds that reduces its blood compatibility and limits its application as an implantable medical device. 4,5 Furthermore, its fragility and low mechanical strength make it difficult to meet the relevant requirements of bone repair materials. 6 The standard methods used to obtain a material exhibiting blood compatibility include physical blending, chemical synthesis, and surface modification.…”

Section: Introductionmentioning

confidence: 99%

Oriented homo‐epitaxial crystallization of polylactic acid displaying a biomimetic structure and improved blood compatibility

Chen

et al. 2021

J Biomedical Materials Res

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Epitaxial crystallization and solid hot-drawing technology were employed to fabricate oriented homo-epitaxial crystallization of polylactic acid (PLA) with nano-topography to enhance its blood compatibility and mechanical characteristics as blood-contacting medical devices. The process involved solid hot stretching the PLA plates. A PLA nutrient solution was then used to immerse the oriented plates to dissolve some of the PLA solutes, ensuring plate integrity. Consequently, the drawing process exponentially enhanced the modulus and tensile strength of the PLA. Orientation and epitaxial crystallization could substantially enhance blood compatibility of PLA by prolonging clotting time and decreasing hemolysis rate, protein adsorption, and platelet activation. The oriented homo-epitaxial crystallization of PLA exhibited a nanotopography and fibrous structure similar to the intimal layer of a blood vessel, and this biomimetic structure was advantageous in decreasing the activation and/or adhesion of platelets.

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Preparation and blood compatibility of electrospun nanofibrous CTS/PLA mats from chitosan nanopowders and poly(lactic acid)

Cited by 12 publications

References 47 publications

Nanoporous PLA/(Chitosan Nanoparticle) Composite Fibrous Membranes with Excellent Air Filtration and Antibacterial Performance

Nanoporous PLA/(Chitosan Nanoparticle) Composite Fibrous Membranes with Excellent Air Filtration and Antibacterial Performance

Facile Method for Surface-Grafted Chitooligosaccharide on Medical Segmented Poly(ester-urethane) Film to Improve Surface Biocompatibility

Oriented homo‐epitaxial crystallization of polylactic acid displaying a biomimetic structure and improved blood compatibility

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