Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26

Pang, Zhiqing; Lü, Wei; Gao, Huile; Hu, Kaili; Chen, Jun; Zhang, Chaolin; Gao, Xiaoling; Jiang, Xinguo; Zhu, Changhong

doi:10.1016/j.jconrel.2008.03.007

Cited by 254 publications

(199 citation statements)

References 34 publications

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“…Many researchers have used it as a fluorescence probe of nano drug delivery systems in quality and quantity analysis [5,27] . Although the release speed at pH 4.0 was quicker than that at pH 7.4, the cumulative released percentage of both was smaller than 0.12% (Figure 2), which is similar to other studies [5,23,27] . This suggested that most of the incorporated coumarin-6 remained in the particles and indicated that the fluorescence signal detected in the cell or tissue samples was attributed mainly to the coumarin-6 encapsulated into the particles.…”

Section: Wwwnaturecom/aps Gao Hl Et Alsupporting

confidence: 90%

“…Recently, most of the brain targeting moieties are either the related ligands of known receptors, or carriers on the BBB or the cationic proteins, which can bind with the anionic BBB, such as transferrin receptor monoclonal antibody OX26, insulin, and cationic albumin [23,27,36] . However, these targeting ligands generally present problems such as low specificity and not ideal brain targeting properties.…”

Section: Wwwnaturecom/aps Gao Hl Et Almentioning

confidence: 99%

“…Polymersomes (PSs), as a new class of synthetic thin-shelled capsules based on block copolymer chemistry, are self-assembled vesicles of amphiphilic block copolymers with thicker and tougher membranes than lipids [21,22] . Compared with liposomes, PSs contain many advantages such as adjustable amphiphile molecular weight (MW) and ratio, tunable physical and chemical properties, and tunable in vivo behavior [23] . Pang et al confirmed that PSs could be employed as vectors to develop a brain targeting drug delivery system [23] .…”

Section: Introductionmentioning

confidence: 99%

“…Compared with liposomes, PSs contain many advantages such as adjustable amphiphile molecular weight (MW) and ratio, tunable physical and chemical properties, and tunable in vivo behavior [23] . Pang et al confirmed that PSs could be employed as vectors to develop a brain targeting drug delivery system [23] .…”

Section: Introductionmentioning

confidence: 99%

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Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations

et al. 2010

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Aim:To evaluate the effect of lactoferrin (Lf) and transferrin (Tf) in brain targeting. Methods: Polymersomes (PSs), employed as vectors, were conjugated with Lf or Tf and were characterized by morphology, particle size, zeta potential, and surface densities of the Lf or Tf molecules. In vitro uptake of Lf-PS and Tf-PS by bEnd.3 cells was investigated using coumarin-6 as a fluorescent probe. In vivo tissue distribution and pharmacokinetics of 125 I-Lf-PS and 125 I-Tf-PS were also examined. Results: The mean particle size of PS, Lf-PS, and Tf-PS was around 150 nm and the zeta potential of the PSs was about -20 mV. Less than 0.12% of the coumarin was released from coumarin-6-loaded PS in 84 h indicating that coumarin-6 was an accurate probe for the PSs' behavior in vitro. It was shown that the uptake of Lf-PS and Tf-PS by bEnd.3 cells was time-, temperature-, and concentrationdependent. Both Lf and Tf could increase the cell uptake of PSs at 37°C, but the uptake of Tf-PS was significantly greater than that of Lf-PS. In vivo tissue distribution and pharmacokinetics in mice revealed higher brain uptake and distribution of Tf-PS than Lf-PS, which was in accordance with in vitro uptake results. The drug targeting index (DTI) of Tf-PS with regard to Lf-PS was 1.51. Conclusion: Using a PS as the delivery vector and bEnd.3 cells as the model of the blood-brain barrier (BBB), Tf was more effective than Lf in brain targeting.

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Section: Wwwnaturecom/aps Gao Hl Et Alsupporting

confidence: 90%

Section: Wwwnaturecom/aps Gao Hl Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations

et al. 2010

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“…[121] Pang et al have also reported the successful in vivo rat brain delivery of peptide-loaded PEO-PCL vesicles, ameliorating the scopolamine-induced learning and memory impairments in rats. [125] Therapeutic oxygen carriers based on PEO-PCL or PEO-PLA copolymer vesicles that are successfully loaded with either human or bovine haemoglobin that exhibits good oxygen binding and release, have been developed for potential applications as haemoglobinbased oxygen carriers for the treatment of ischemic tissues. [126] Membrane Loading of Polymer Vesicles for Medical Uses…”

Section: Reactive and Environmentally Responsive Membranes For Delivementioning

confidence: 99%

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Blanazs

Armes

Ryan

2009

Macromol. Rapid Commun.

1,409

1,370

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The ability of amphiphilic block copolymers to self‐assemble in selective solvents has been widely studied in academia and utilized for various commercial products. The self‐assembled polymer vesicle is at the forefront of this nanotechnological revolution with seemingly endless possible uses, ranging from biomedical to nanometer‐scale enzymatic reactors. This review is focused on the inherent advantages in using polymer vesicles over their small molecule lipid counterparts and the potential applications in biology for both drug delivery and synthetic cellular reactors.magnified image

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Polymer Nanoreactors

Edlinger¹,

Zhang²,

Fischer-Onaca³

et al. 2013

Encyclopedia of Polymer Science and Technology

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This article introduces protein–polymer systems that serve as chemical reaction spaces at the nanoscale. Such polymeric nanoreactors accommodate enzymatic reactions either inside polymer supramolecular assemblies or at their interfaces with the environment, or through a combination of both. We provide an overview of polymer structures that include micelles, vesicles (primarily polymersomes, but also PICsomes and peptosomes), dendrimers, layer‐by‐layer capsules, and capsids—all of which can accommodate sensitive biomolecules to mimic natural systems and functions. This article further deals with the functionalization of polymer membranes and the analytical techniques that apply to nanoreactors. In the last section, we highlight the most relevant applications of such polymeric nanoreactors in the domains of medicine, ecology, and biotechnology.

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Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26

Cited by 254 publications

References 34 publications

Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations

Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations

Self‐Assembled Block Copolymer Aggregates: From Micelles to Vesicles and their Biological Applications

Polymer Nanoreactors

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