Preparation and Cancer Cell Invasion Inhibitory Effects of C16-Alkynic Fatty Acids.

Ohashi, Kazuhiko; Winarno, Hendig; Mukai, Mutsuko; Shibuya, Hitoshi

doi:10.1248/cpb.51.463

Cited by 17 publications

(10 citation statements)

References 11 publications

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“…[146], and stem of Elytranthe parasitica (L.) Danser [147] also exerted cytotoxic effects. In addition, the alkynic fatty acids from S. atropurpurea potently inhibited in vitro tumor cell invasion [148], and extracts from the stem or leaves of S. oortiana increased tumor cell sensitivity to TNF-α-mediated lysis [145]. The cat's claw U. guianensis (Figure 8) is indigenous to the Amazonian parts of Paraguay, Brazil, Bolivia, Peru, Ecuador, Colombia, Venezuela, and the Guyanas.…”

Section: Loranthaceae-phthirusa Stelis (L) Kuijtmentioning

confidence: 99%

Anticancer Activity of Uncommon Medicinal Plants from the Republic of Suriname: Traditional Claims, Preclinical Findings, and Potential Clinical Applicability against Cancer

Mans¹,

Irving²

2019

Pharmacognosy - Medicinal Plants

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Despite much progress in our understanding of the essence of cancer, remarkable advances in methods for early diagnosis, the expanding array of antineoplastic drugs and treatment modalities, as well as important refinements in their use, this disease is among the leading causes of morbidity and mortality in many parts of the world. In fact, the next decade is anticipated to bring over 20 million new cases per year globally, about half of whom will die from their disease. This indicates a need for better strategies to deal with cancer. One way to go forward is to draw lessons from ancient ethnopharmacological wisdom and to evaluate the plant biodiversity for compounds with potential antineoplastic activity. This approach has already yielded many breakthrough cytotoxic drugs such as vincristine, etoposide, paclitaxel, and irinotecan. The Republic of Suriname (South America), renowned for its pristine and highly biodiverse rain forests as well as its ethnic, cultural, and ethnopharmacological diversity, could also contribute to these developments. This chapter addresses the cancer problem throughout the world and in Suriname, extensively deals with nine plants used for treating cancer in the country, and concludes with their prospects in anticancer drug discovery and development programs.

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Section: Loranthaceae-phthirusa Stelis (L) Kuijtmentioning

confidence: 99%

Anticancer Activity of Uncommon Medicinal Plants from the Republic of Suriname: Traditional Claims, Preclinical Findings, and Potential Clinical Applicability against Cancer

Mans¹,

Irving²

2019

Pharmacognosy - Medicinal Plants

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“…Beberapa penelitian serupa yang mendukung aktivitas senyawa tersebut dilaporkan antara lain oleh Ohashi, et al, yang melaporkan bahwa senyawa aktif yang diisolasi dari benalu teh, yaitu asam oktadeka-8,10,12-trinoat teruji secara in vitro dan in vivo bekerja menghambat invasi sel kanker sehingga sel tidak mengalami metastasis. 19 Winarno dalam penelitiannya mengenai aktivitas antipoliferasi asam oktadeka-8,10,12-triunoat terhadap galur sel kanker manusia melaporkan bahwa senyawa tersebut memiliki aktivitas antiproliferasi terhadap empat jenis galur sel kanker manusia, yaitu sel HeLa, leukemia THPI, karsinoma paru-paru A549, dan limfoma HUT78 dengan nilai LC50 berturut-turut 0,66; 0,86; 0,99; dan 2,36 ppm. 20 Selain itu, Kumar et al, serta Maruthupandian dan Mohan juga melaporkan hal yang sama.…”

Section: Hounclassified

Identifikasi Isolat Antikanker Spons Hyrtios Erecta

Swantara¹,

Rita²,

Hernindya³

2017

Indonesian Journal of Cancer

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Isolation, anticancer activity test, and identification of the toxic isolate from ethanol extract of the sponge Hyrtios erecta taken from Pari Island beach (Jakarta) has conducted. Extraction of the sponges was carried out by 70% ethanol at room temperature. Partition and purification of the compounds were done by column chromatography with the stationary phase of silica gel and the mobile phase of n-hexane-chloroform (2:8). Toxicity screening test was done based on BhrineShrimp Lethality Test (BSLT). In vitro anticancer activity test of the isolate was carried out using HeLa cell line. Identification of the compounds was performed by Gas chromatography-mass spectroscopy (GC-MS). Based on theresults, it was found that the toxic isolate of H. erecta sponges has anticancer activity with IC50 of 30,497 ppm. Four compounds was detected from the anticancer isolate i.e: 4-nonylphenol; dibutyl phthalate; hexanedioic acid bis(2-ethylhexyl) ester; and cholesterol. ABSTRAKTelah dilakukan isolasi, uji aktivitas antikanker, dan identifikasi isolat toksik yang berasal dari ekstrak etanol spons Hyrtios erecta yang diambil dari perairan Pulau Pari (Jakarta). Ekstraksi dilakukan dengan cara maserasi menggunakan etanol 70% pada temperatur kamar. Pemisahan dan pemurnian komponen menggunakan kromatografi kolom dengan fase diam silikagel dan fase gerak n-heksana-kloroform (2:8). Skrining toksisitas dilakukan dengan metode Bhrine Shrimp Lethality Test (BSLT). Uji antikanker secara in vitro isolat toksik tersebut menggunakan sel HeLa. Senyawanya diidentifikasi menggunakan Gas chromatography-mass spectroscopy (GC-MS). Berdasarkan hasil penelitian ini diperoleh bahwa isolat toksik spons H. erecta bersifat antikanker dengan IC50 sebesar 30,497 ppm. Pada isolat antikankertersebut terdeteksi empat senyawa, yaitu 4-nonylphenol; dibutil phtalat; ester heksadioat bis(2-etilheksil); dan kolesterol.

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“…All compounds showed inhibitory activity against cancer cell invasion (MM1) in vitro (Table 8) [74]. Five C 16 -acetylenic fatty acids, hexadec-8-ynoic acid (87), hexadec-10-ynoic acid (88), hexadeca-8,10diynoic (89), hexadeca-6,8,10-trienoic (90), and hexadeca-8,10,12-triynoic (91) acids were prepared and their inhibitory activity against cancer cell invasion examined [75]. The results indicated that the natural C 18 -triyne fatty acid 86 92, and asparenydiol (93).…”

Section: Acetylenic Metabolites From Plant Speciesmentioning

confidence: 99%

Acetylenic Terrestrial Anticancer Agents

Dembitsky

Levitsky

2006

Natural Product Communications

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Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. This review presents 139 active acetylenic molecules of plant, fungal, and soil bacterial origin that reveal cytotoxic and/or anticancer activities. Although many compounds of this group possess encouraging characteristics, they have never been evaluated as potential anticancer agents. They are of great interest, especially for the medicine and/or pharmaceutical industries. Here we describe structures and biological activities of acetylenic metabolites.

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Preparation and Cancer Cell Invasion Inhibitory Effects of C16-Alkynic Fatty Acids.

Cited by 17 publications

References 11 publications

Anticancer Activity of Uncommon Medicinal Plants from the Republic of Suriname: Traditional Claims, Preclinical Findings, and Potential Clinical Applicability against Cancer

Anticancer Activity of Uncommon Medicinal Plants from the Republic of Suriname: Traditional Claims, Preclinical Findings, and Potential Clinical Applicability against Cancer

Identifikasi Isolat Antikanker Spons Hyrtios Erecta

Acetylenic Terrestrial Anticancer Agents

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