Preparation and characterization of a novel hamada scoparia polysaccharide composite films and evaluation of their effect on cutaneous wound healing in rat

Biological activities and wound healing potential of a water-soluble polysaccharide isolated from Glycyrrhiza glabra in Wistar rat

“…This fact indicated a final step of remodeling phase healing. Additionally, previous reports demonstrated that Free radicals and oxidative reaction products in lipid peroxidation induce tissue destruction and play a major role in the irritation of tissue (Eleroui et al, 2021). In this context and in accordance with above obtained in vitro antioxidant activities, it may be concluded that our sample is an antioxidant agent, which can quenches free radicals by electron-donating mechanism, supplying a protective effect of cells from oxidative damage in wound healing process (Eleroui et al, 2021;Carmignan et al, 2019).…”

Polysaccharides from South Tunisian Moringa alterniflora Leaves: Characterization, Cytotoxicity, Antioxidant Activity, and Laser Burn Wound Healing in Rats

“…This finding is in accordance with previous work by Ktari et al [ 53 ] and Mapoung et al [ 54 ] showing the benefic effect of polysaccharides in healing wounds. The amino acid hydroxyproline is normally found in significant quantity in collagen and its measurement can be used as an indicator of collagen formation [ 55 , 56 ]. Data revealed that MLWSP significantly accelerated wound healing after 8 days of treatment, attested by higher wound area measurement and a higher content of collagen (estimated by hydroxyproline content), and was confirmed by histological examination, when compared with control, cytol centella ® , physiological serum, and glycerol groups.…”

“…Data revealed that MLWSP significantly accelerated wound healing after 8 days of treatment, attested by higher wound area measurement and a higher content of collagen (estimated by hydroxyproline content), and was confirmed by histological examination, when compared with control, cytol centella ® , physiological serum, and glycerol groups. In fact, the increasing collagen synthesis and deposition displayed a critical role in wound closure [ 56 ]. In this trend, Trablesi et al [ 57 ] have previously reported that the high concentration of hydroxyproline can be explained by the capacity of polysaccharides to promote fibroblast migration by supplying a connective tissue matrix.…”

“…The physiological serum-treated group, in comparison, had an open wound that healed more slowly than the other groups. The most effective way for assessing the extent of wound healing is a histological examination of wound tissues [ 56 ]. Hematoxylin-colored micrograph slices are examined under light microscopy to evaluate the inflammatory and regenerative features, such as tissue congestion and neutrophil infiltration.…”

Agaricus blazei Murill extract‐loaded in alginate/poly(vinyl alcohol) films prepared by Ca2+ cross‐linking for wound healing applications

“…[44][45][46] Extracts rich in sugars or polysaccharides can act by stimulating the angiogenesis process, which accelerates the wound healing. [47][48][49] Furthermore, topical treatment of wounds with sugars promotes the nutrition of the skin and reduces inflammation, as well stimulates the process of re-epithelialization of the injured tissue. Such molecules also have bacteriostatic activity and promote osmotic changes in pathogens that may be infecting the wound.…”