Preparation and characterization of a metered dose transdermal spray for testosterone

Lu, Wangding; Luo, Haoming; Wu, Yubo; Zhu, Zhuangzhi; Wang, Hao

doi:10.1016/j.apsb.2013.10.003

Cited by 14 publications

(13 citation statements)

References 21 publications

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“…Research conducted by Lu et al 32 shows that Plasdone can increase testosterone permeation better than other polymers. The best testosterone permeation sequence was Plasdone > Eudragit EPO > PVP K30 > Eudragit RL.…”

Section: Plasdonementioning

confidence: 99%

“…Ease of use can also increase patient compliance. 20,[30][31][32][33] The thin film is easy to wash away with water. 20,34 This thin and non-sticky film also increases patient comfort during activities compared to using patches, ointments, gels, etc., because these have a rough and sticky texture when applied.…”

Section: Definition and Mechanism Of A Film-forming Spraymentioning

confidence: 99%

“…45 The average amount of FFS that can be sprayed is 90-102 mL. 30,32,33 The average spray angle of MDS is 83.51°. 20 The average leakage rate of an MDS container is 0.01-0.02 %.…”

Section: Metered Dose Spraymentioning

confidence: 99%

“…34,40,41 Because it has hydrophobic properties, camphor and menthol can increase drug permeation through interactions with the lipids of the stratum corneum. 93 Research conducted by Lu et al 32 showed that the order of permeation enhancers that is the best for increasing testosterone permeation is azone > isopropyl myristate (IPM) > propylene glycol (PG) > N-methyl-2-pyrrolidone (NMP). Furthermore, the results of a study by Lu et al 33 showed that dexketoprofen permeation was better using lauryl lactate (LA) > IPM > azone > PG as permeation enhancers.…”

Section: Permeation Enhancersmentioning

confidence: 99%

“…Drug levels are determined at sprays 5, 10, 20, 30, and 50 by collecting sprays, then measuring them instrumentally. 32 Potential Drug Aggregation…”

Section: Spray Anglementioning

confidence: 99%

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<p>Film-Forming Sprays for Topical Drug Delivery</p>

Umar¹,

Butarbutar²,

Sriwidodo³

et al. 2020

DDDT

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Film-forming sprays offer many advantages compared to conventional topical preparations because they can provide uniform drug distribution and dose, increased bioavailability, lower incidence of irritation, continuous drug release, and accelerated wound healing through moisture control. Film-forming sprays consist of polymers and excipients that improve the characteristics of preparations and enhance the stability of active substances. Each type of polymer and excipient will produce films with different features. Therefore, the various types of polymers and excipients and their evaluation standards need to be examined for the development of a more optimal form of film-forming spray. The selected literature included research on polymers as film-forming matrices and the application of these sprays for medical purposes or for potential medical use. This article discusses the types and concentrations of polymers and excipients, sprayer types, evaluations, and critical parameters in determining the sprayability and film characteristics. The review concludes that both natural and synthetic polymers that have in situ film or viscoelastic properties can be used to optimise topical drug delivery.

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Section: Plasdonementioning

confidence: 99%

Section: Definition and Mechanism Of A Film-forming Spraymentioning

confidence: 99%

“…45 The average amount of FFS that can be sprayed is 90-102 mL. 30,32,33 The average spray angle of MDS is 83.51°. 20 The average leakage rate of an MDS container is 0.01-0.02 %.…”

Section: Metered Dose Spraymentioning

confidence: 99%

Section: Permeation Enhancersmentioning

confidence: 99%

“…Drug levels are determined at sprays 5, 10, 20, 30, and 50 by collecting sprays, then measuring them instrumentally. 32 Potential Drug Aggregation…”

Section: Spray Anglementioning

confidence: 99%

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