Preparation and characterization of ABS and copper (II) sulfate coordination composites by planetary ball mill

Fu, Zhiwei; Mao, Yapeng; Li, Shourui; Liu, Shouchao; Shao, Chengli; Shang, Peng; Li, Qiuying; Wu, Chifei

doi:10.1007/s00289-017-2042-y

Cited by 5 publications

(1 citation statement)

References 52 publications

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“…[11] Traditional chemotherapy, along with surgery and radiation therapy, is the main treatment for breast cancer. [12] However, it affects normal cells and limits drug dosage reaching tumor cells, reducing treatment effectiveness. The research on metal complexes, including platinum-based drugs, has gained attention in anticancer studies.…”

Section: Introductionmentioning

confidence: 99%

A Novel Combined Nanoparticle Delivery of Poly(ADP-Ribose) Polymerase Inhibitor-Olaparib and Copper Complexes for Chemosensitization Therapy in Breast Cancer

Huang,

Liu

2023

Med. Res.

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Chemo-sensitization therapy has gained importance in the field of anti-cancer treatment in recent years. The combination of both chemotherapy and chemosensitization has unique advantages. However, there has been relatively limited research on combination treatment using metal complexes and chemosensitizers. Herein, we reports a two-drug synergistic delivery system combining a copper complex and a chemosensitizer Olaparib in a certain ratio of safety and efficiency is the key. Polyethylenimine (PEI) was chemically-linked to activated chemosensitizer Olaparib, which was connected to a bifunctional peptide, T15, for facilitation and nuclear targeting, resulting in Ola-PEI-T15. Then, a novel metal complex Cu/Ola-PEI-T15 was obtained by Cu 2+ coordination to Ola-PEI-T15. The two therapeutic agents can be transported into the cells at the same time, giving full play to the synergistic anti-tumor effect.

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Section: Introductionmentioning

confidence: 99%