Preparation and characterization of alloys of the Ti–15Mo–Nb system for biomedical applications

Júnior, José Roberto Severino Martins; Matos, Adriana Arruda; Oliveira, Rodrigo Cardoso de; Buzalaf, Marília Afonso Rabelo; Costa, Isolda; Rocha, L. A.; Grandini, Carlos Roberto

doi:10.1002/jbm.b.33868

Cited by 20 publications

(12 citation statements)

References 34 publications

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“…The use of titanium alloys in offshore structures and marine applications results from it low density, superior strength, and extremely high resistance to corrosion [2,3,[15][16][17][18][19][20]. Another important usage of titanium alloys is as an outstanding and strong material in the field of biomedical implantations [8][9][10][11][12][13][14][15]21].…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Vanadium Additions on the Corrosion of Ti6AlxV Alloys in Chloride Solutions

Sherif

Abdo

Alharthi

2020

Metals

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The beneficial effects of V addition on the corrosion of a newly manufactured Ti6AlxV (x = 2 wt %, 4 wt %, 6 wt %, and 8 wt %) alloys after various exposure periods in 3.5% NaCl solutions were reported. The Ti6AlxV were produced from their raw powders using mechanical alloying. Several electrochemical techniques such as electrochemical impedance spectroscopy, cyclic potentiodynamic polarization, and potentiodynamic current versus time at 300 mV experiments were conducted. The surface morphology and the elemental analysis were performed using scanning electron microscopy and energy dispersive X-ray analyses. All results were consistent with each other revealing that the increase of V content increases the resistance of the alloys against corrosion. The increase of corrosion resistance was achieved by the role of V in decreasing the rate of corrosion as a result of the formation of oxide films on the surface of the alloys. This effect was found to increase with prolonging the immersion time of the Ti6AlxV alloys in the test medium from 1 h to 24 h and further to 48 h. particularly in implantation systems [24][25][26]. Other titanium alloys like Ti6Al7Nb and Ti13Cu4.5Ni, in addition to the Ti6Al4V alloy, have been selected as the only choice for the use in orthopedic implants [27]. It has also been reported [28][29][30][31][32][33][34] that resistance versus corrosion in-vitro to form a stable oxide film in harsh media is the main reason for these alloys to be popular and applicable in the field of biomedical applications.In this work, we aimed to produce a series of Ti-base alloys, namely Ti6Al2V, Ti6Al4V, Ti6Al6V, and Ti6Al8V alloys, from its pure powders, and reported their corrosion after immersion in 3.5% NaCl solution for different periods of time, namely 1 h, 24 h, and 48 h. The effect of increasing V content within the fabricated alloys on their corrosion in the test solution was reported using various electrochemical techniques like polarization, electrochemical impedance spectroscopy, and potentiostatic current-time at 300 mV (Ag/AgCl). Other surface analysis methods, including scanning electron microscopy (SEM) images and energy dispersive X-ray (EDX) spectra, were performed to ensure the compositions, the surface morphology, and expected corrosion products that might be formed after corrosion due to the reaction between the surfaces of the alloys and the chloride test solution.

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Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Vanadium Additions on the Corrosion of Ti6AlxV Alloys in Chloride Solutions

Sherif

Abdo

Alharthi

2020

Metals

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“…Chemical characterization was completed by conducting corrosion tests and considering that these alloys were designed as β-Ti alloys. These alloys exhibited better corrosion behavior than the rest [41].…”

Section: Discussionmentioning

confidence: 93%

Laser Surface Modification in Ti-xNb-yMo Alloys Prepared by Powder Metallurgy

Tendero

Rossi

Viera

et al. 2021

Metals

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The main objective was to study the effect of surface modification by laser on Ti-Nb-Mo powder metallurgical alloys to improve their mechano-chemical behavior and their application as a biomedical implant. The used powder mixtures were produced in an inert atmosphere. Uniaxial compaction took place at 600 MPa with high-vacuum sintering at 1250 °C for 3 h. The specimens for the three-point flexure test were prepared and their mechanical properties determined. Microstructural characterization was performed by scanning electron microscopy (SEM) and X-ray diffraction (XRD) to obtain the distribution of phases, porosity, size, and shape of the grains of each alloy. Corrosion behavior was evaluated by electrochemical tests using an artificial saliva electrolyte modified from Fusayama at 37 °C. Chemical characterization was completed by analyzing the ionic release by Inductively coupled plasma atomic emission spectroscopy (ICP-EOS) after immersion for 730 h in Fusayama solution modified with NaF at 37 °C to simulate a 20-year life span based on a daily 2-min cycle of three toothbrushes. Corrosion behavior confirmed promising possibilities for the biomedicine field. The surface porosity of the samples not submitted to surface treatment deteriorated properties against corrosion and ion release. The obtained phase was β, with a low α”-martensite percentage. The maximum resistance to bending was greater after surface fusion. Plastic deformations were above 7% under some conditions. Microhardness came close to 300 HV in heat-affected zone (HAZ) and 350 HV in fusion zone (FZ) (under the determined condition. The elastic modulus lowered by around 10%. The corrosion rate was lower in Ti-27Nb-8Mo and Ti-35Nb-6Mo. Niobium release was significant, but below the physiological limit.

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“…Surface treatments like polishing, sandblasting, acid etching, coatings, nanotextures, and biofunctionalization have been proposed and tested over titanium and zirconia. 6,[17][18][19][20][21][22] As found in the literature, the anodization process improves cell attachment and proliferation, 23 but less work has been done on the final steps of osseointegration and the bone quality obtained.…”

Section: Discussionmentioning

confidence: 99%

Osteoblastic response to biomaterials surfaces: Extracellular matrix proteomic analysis

Graeff¹,

Tokuhara²,

Sanches³

et al. 2021

J Biomed Mater Res

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The cellular response to surfaces is mediated, among other factors, by the extracellular matrix (ECM). However, little is known about the ECM proteome during mineralization. Our objective was to compare the ECM composition formed by osteoblast on different materials surfaces with proteomic analysis. Three types of biomaterial surfaces (pure titanium, anodized titanium, and zirconia) were used. Osteoblasts (MC3T3 linage) cells were cultivated on the biomaterials for 7, 14, and 21 days with the osteogenic medium. For the proteomic analysis, the specimens were washed, decellularized, and the ECM was collected. The majority of the typical ECM proteins, out of a total of 24 proteins identified, was expressed and regulated equally on the three biomaterials tested. Alpha-1,4 glucan phosphorylase was found to be downregulated on zirconia on the seventh day, while at the same time, glycogen phosphorylase brain form was up-regulated on anodized titanium, both when compared with pure titanium (ratio: 1.06 and 0.97, respectively). And after 14 days of culture, glycogen phosphorylase brain form was downregulated on zirconia when compared with pure titanium (ratio: 0.90), suggesting the influence of material surface roughness and chemical composition on energy metabolism. Proteins related to bone development like Transforming growth factor beta-3 and Fibroblast growth factor 8 were found exclusively on pure titanium on the 21st day. Altogether, our results show a possible influence of material surfaces on the composition of ECM.

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Preparation and characterization of alloys of the Ti–15Mo–Nb system for biomedical applications

Cited by 20 publications

References 34 publications

Beneficial Effects of Vanadium Additions on the Corrosion of Ti6AlxV Alloys in Chloride Solutions

Beneficial Effects of Vanadium Additions on the Corrosion of Ti6AlxV Alloys in Chloride Solutions

Laser Surface Modification in Ti-xNb-yMo Alloys Prepared by Powder Metallurgy

Osteoblastic response to biomaterials surfaces: Extracellular matrix proteomic analysis

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