Preparation and Characterization of an Oral Norethindrone Sustained Release/Controlled Release Nanoparticles Formulation Based on Chitosan

Al-Taani, Bashar; Al-Nimry, Suhair S.; Haddad, Razan; Abu-Dahab, Rana

doi:10.1208/s12249-018-1261-3

Cited by 13 publications

(12 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such data emphasized the stability of F-9 at 4 ± 1 °C for 3 months demonstrated by uniform nanosize range together with homogenic dispersion. Similar findings, with regard to the storage stability study of CS/STPP NPs, were declared previously 30 . Table 4.…”

Section: Formula Coefficients Of Determination (R 2 ) Korsmeyer-peppas Weibullsupporting

confidence: 90%

“…The influence of storage conditions (namely; temperature) on the physical stability of the optimized ALL-loaded CS/STPP NPs (F-9) was assessed. The freshly prepared ALL-loaded CS/STPP NPs dispersions (F-9) were filled in screw capped glass bottles and stored at refrigeration (4 ± 1 °C) and ambient conditions for 3 months without any stirring or agitation 30 . The NPs were assessed regarding particle size, PDI, ZP and average drug retention (%) at zero time (at production day as described above previously), and after 1 and 3 months of storage.…”

Section: Short-term Physical Stability Of All-loaded Cs/stpp Nps (F-9mentioning

confidence: 99%

“…In terms of stability, the effect of temperature (4 and 25 °C) on the physical stability of the optimized formula (F-9) was evaluated. However, owing to the storage of the samples into screw capped glass bottles, the influence of the relative humidity has not been considered 30 .…”

Section: Formula Coefficients Of Determination (R 2 ) Korsmeyer-peppas Weibullmentioning

confidence: 99%

See 2 more Smart Citations

Formulation, optimization and characterization of allantoin-loaded chitosan nanoparticles to alleviate ethanol-induced gastric ulcer: in-vitro and in-vivo studies

Aman

Zaghloul

El-Dahhan

2021

Sci Rep

View full text Add to dashboard Cite

Allantoin (ALL) is a phytochemical possessing an impressive array of biological activities. Nonetheless, developing a nanostructured delivery system targeted to augment the gastric antiulcerogenic activity of ALL has not been so far investigated. Consequently, in this survey, ALL-loaded chitosan/sodium tripolyphosphate nanoparticles (ALL-loaded CS/STPP NPs) were prepared by ionotropic gelation technique and thoroughly characterized. A full 24 factorial design was adopted using four independently controlled parameters (ICPs). Comprehensive characterization, in vitro evaluations as well as antiulcerogenic activity study against ethanol-induced gastric ulcer in rats of the optimized NPs formula were conducted. The optimized NPs formula, (CS (1.5% w/v), STPP (0.3% w/v), CS:STPP volume ratio (5:1), ALL amount (13 mg)), was the most convenient one with drug content of 6.26 mg, drug entrapment efficiency % of 48.12%, particle size of 508.3 nm, polydispersity index 0.29 and ζ-potential of + 35.70 mV. It displayed a sustained in vitro release profile and mucoadhesive strength of 45.55%. ALL-loaded CS/STPP NPs (F-9) provoked remarkable antiulcerogenic activity against ethanol-induced gastric ulceration in rats, which was accentuated by histopathological, immunohistochemical (IHC) and biochemical studies. In conclusion, the prepared ALL-loaded CS/STPP NPs could be presented to the phytomedicine field as an auspicious oral delivery system for gastric ulceration management.

show abstract

Section: Formula Coefficients Of Determination (R 2 ) Korsmeyer-peppas Weibullsupporting

confidence: 90%

Section: Short-term Physical Stability Of All-loaded Cs/stpp Nps (F-9mentioning

confidence: 99%

See 1 more Smart Citation

Formulation, optimization and characterization of allantoin-loaded chitosan nanoparticles to alleviate ethanol-induced gastric ulcer: in-vitro and in-vivo studies

Aman

Zaghloul

El-Dahhan

2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In the second set (after extraction) the blank samples were first extracted and the residue was spiked with norethindrone and the internal standard, reconstituted with the mobile phase, and injected. NLF was prepared and the details of the preparation and optimization of the NLF were published previously [9] .…”

Section: Liquid-liquid Extraction Of Plasma Samplesmentioning

confidence: 99%

“…Estradiol used was used as an internal standard. The developed method was used to study the bioavailability of norethindrone after in vivo administration of a previously prepared nanoparticulate liquid formulation (NLF) to dogs [9] . It was also used to determine the adhesion potential of the formulation to stomach and intestine after in vivo administration to mice.…”

mentioning

confidence: 99%