Preparation and characterization of antibacterial polyvinyl alcohol/chitosan sponge and potential applied for wound dressing

Fan, Yao; Lu, Qiaohui; Liang, Wencheng; Wang, Youchang; Zhou, Yan; Lang, Meidong

doi:10.1016/j.eurpolymj.2021.110619

Cited by 35 publications

(5 citation statements)

References 49 publications

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“…Figure 3 illustrates the FTIR spectra of all samples, and the main characteristic peaks with corresponding chemical bonds are listed in Table 2. As presented, the peak at 3300–3500 cm −1 was assigned to OH 54 . The absorption peaks of the pure PVA sponge at ν = 2900 cm −1 correspond to the stretching vibration of CH in PVA 51 .…”

Section: Resultsmentioning

confidence: 76%

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Fabricating of poly(vinyl alcohol)/halloysite nanotubes/gelatin composite sponges with enhanced mechanical properties and rapid water absorption speed

Wu,

Chen,

Feng

et al. 2023

Polymer Engineering & Sci

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In the biomedical field, polyvinyl alcohol (PVA) sponge has been widely used. In particular, it is considered a potential implant material for repairing soft tissues. However, its insufficient water absorption and mechanical properties limit its application. In this work, a novel PVA/halloysite nanotubes (HNTs)/gelatin ternary composite sponge was prepared by water solution mixing and casting techniques. HNTs and gelatin/PVA solution were mixed at different weight ratios. The structure of the ternary composite sponges was characterized by using scanning electron microscopy. The physical properties of the ternary composite sponges were characterized. The maximum water absorption reached 1783.5% with a rapid water absorption speed at a weight ratio of HNTs/gelatin of 1:8. Owing to its interconnected macroporous structure and good interfacial interaction, its highest compression strength and tensile strength reached 8.22, 1.51 MPa, respectively. In addition, its thermal stability was enhanced as well, which demonstrated that the prepared composite sponge had better performance than the pure PVA sponge by constructing a ternary system. Therefore, the results suggest that the PVA/HNTs/gelatin ternary composite sponge shows a wider application value as a potential material for repairing soft tissue.Highlights A composite PVA sponge with promising applications in tissue engineering. Simple preparation method, water solution mixing and casting techniques. Pioneering a PVA/HNTs/gelatin ternary system sponge. Improved water absorption ability and mechanical properties.

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Section: Resultsmentioning

confidence: 76%

“…As presented, the peak at 3300-3500 cm À1 was assigned to OH. 54 The absorption peaks of the pure PVA sponge at ν = 2900 cm À1 correspond to the stretching vibration of C H in PVA. 51 The band at ν = 1045 cm À1 is attributed to the C O H stretching vibration in fatty alcohols.…”

Section: Ftir Spectrummentioning

confidence: 99%

Fabricating of poly(vinyl alcohol)/halloysite nanotubes/gelatin composite sponges with enhanced mechanical properties and rapid water absorption speed

Wu,

Chen,

Feng

et al. 2023

Polymer Engineering & Sci

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“…The quantitative hemolysis ratio of all hydrogels was found to be below 5%, indicating that the Pep‐1 hydrogel had excellent blood compatibility (Figure 5B). 42 To sum up, Pep‐1 hydrogel had excellent biocompatibility, making it suitable for use as wound dressing material.…”

Section: Resultsmentioning

confidence: 99%

Wound microenvironment‐responsive peptide hydrogel with multifunctionalities for accelerating wound healing

Dong,

Yang,

Liu

et al. 2024

Journal of Peptide Science

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The fabrication of wound microenvironment‐responsive peptide hydrogels with hemostatic ability, antibacterial activity, and wound healing potential remains a challenge. Herein, we constructed a multifunctional dressing by inducing the self‐assembly of a peptide (Pep‐1) and water‐soluble new methylene blue (NMB) through electrostatic interaction. The self‐assembly mechanism was demonstrated using a combination of transmission electron microscopy, circular dichroism spectrum, fluorescence spectrum, Zeta potential, and rheological analysis. The Pep‐1/NMB hydrogel also exhibited a faster drug release rate in wound acidic environment. Furthermore, when Pep‐1/NMB was exposed to a 635 nm laser, its antibacterial ratios increased sharply to 95.3%, indicating remarkably improved antibacterial effects. The findings from the blood coagulation and hemostasis assay indicated that Pep‐1/NMB effectively enhanced the speed of blood clotting in vitro and efficiently controlled hemorrhage in a mouse liver hemorrhage model. Meanwhile, hemolytic and cytotoxicity evaluation revealed that the hydrogel had excellent hemocompatibility and cytocompatibility. Finally, the findings from the wound healing studies and H&E staining indicated that the Pep‐1/NMB hydrogel had a significant impact on cell migration and wound repair. The results indicated that wound microenvironment‐responsive Pep‐1/NMB hydrogel had significant potential as a highly effective wound dressing platform, offering rapid hemostasis, antibacterial, and wound healing acceleration properties.

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“…6,[7][8][9][10] After the application to the skin surface, the aqueous solution of PVA can form a biocompatible gel membrane. 11,12 Gel membranes originating from pure PVA solution has poor mechanical strength and water vapor permeability 13 and has to be modified to fit specific application scenarios. Numerous attempts have been made in this regard.…”

Section: Introductionmentioning

confidence: 99%

“…Polyvinyl alcohol (PVA) has numerous biomedical applications, such as drug delivery, and is frequently used to construct hydrogels 6,7–10 . After the application to the skin surface, the aqueous solution of PVA can form a biocompatible gel membrane 11,12 . Gel membranes originating from pure PVA solution has poor mechanical strength and water vapor permeability 13 and has to be modified to fit specific application scenarios.…”

Section: Introductionmentioning

confidence: 99%

Polyvinyl alcohol composite gel membrane modified by natural polysaccharide and waterborne polyurethane

Shao,

Li,

Tan

et al. 2023

Polymer Engineering & Sci

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A new composite gel material was obtained by blending polyvinyl alcohol (PVA) aqueous solution with sodium alginate (SA), sodium carboxymethyl cellulose (CMC‐Na), waterborne polyurethane (WPU), and polyvinylpyrrolidone (PVP). Titanium dioxide nanoparticles (nTiO2) were doped as an antibacterial agent. The liquid composite could to form a transparent protective gel membrane. The microstructure of the gel membrane was observed via scanning electron microscopy, and the intermolecular interaction was investigated by total reflection infrared spectroscopy. The results demonstrated a homogeneous phase and significant hydrogen bonding between chain segments. The best results indicated that the equilibrium swelling rate increased from 147% to 170%, the 3‐h water vapor transmission rate increased from 279.41 g/m2∙day to 374.75 g/m2∙day, and the water contact angle increased from 16.8° to 60.7°, relative to the PVA substrate. The properties of this composite gel material suggest possible biomedical usage, particularly in skin and wound protection scenarios.Highlights A novel gel film‐forming material consisting of a viscous liquid is prepared. Adding polysaccharides modifiers resulted in significant improvements of the performance. The bacteriostatic and antihemorrhagic properties are introduced to the material. Low‐irritating materials were used to prepare the gel material.

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Preparation and characterization of antibacterial polyvinyl alcohol/chitosan sponge and potential applied for wound dressing

Cited by 35 publications

References 49 publications

Fabricating of poly(vinyl alcohol)/halloysite nanotubes/gelatin composite sponges with enhanced mechanical properties and rapid water absorption speed

Fabricating of poly(vinyl alcohol)/halloysite nanotubes/gelatin composite sponges with enhanced mechanical properties and rapid water absorption speed

Wound microenvironment‐responsive peptide hydrogel with multifunctionalities for accelerating wound healing

Polyvinyl alcohol composite gel membrane modified by natural polysaccharide and waterborne polyurethane

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