Preparation and characterization of bioceramic nanocomposites based on hydroxyapatite (HA) and carboxymethyl cellulose (CMC)

Annamalai, Pratheep K.; Mohaideen, K. Khaja; Alariqi, Sameh A. S.; Singh, R. P.

doi:10.1007/s13233-010-1208-3

Cited by 23 publications

(9 citation statements)

References 43 publications

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“…These facts are important, especially in the case of viscous liquids with lower values of diffusion coefficients of ions in CXI cements containing CMC where higher contents of liquid are responsible for the existence of a large number of HAP nuclei which are stabilized in colloidal state and creates globular very fine particles or agglomerates like in CXI2 and CXI4 cements. Similar stabilization of colloidal HAP particles was revealed during the precipitation in presence of CMC [53,54].…”

Section: Discussionsupporting

confidence: 72%

Injectable Enzymatically Hardened Calcium Phosphate Biocement

Medvecký

Štulajterová

Giretová

et al. 2020

JFB

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(1) Background: The preparation and characterization of novel fully injectable enzymatically hardened tetracalcium phosphate/monetite cements (CXI cements) using phytic acid/phytase (PHYT/F3P) hardening liquid with a small addition of polyacrylic acid/carboxymethyl cellulose anionic polyelectrolyte (PAA/CMC) and enhanced bioactivity. (2) Methods: Composite cements were prepared by mixing of calcium phosphate powder mixture with hardening liquid containing anionic polyelectrolyte. Phase and microstructural analysis, compressive strength, release of ions and in vitro testing were used for the evaluation of cement properties. (3) Results: The simple possibility to control the setting time of self-setting CXI cements was shown (7–28 min) by the change in P/L ratio or PHYT/F3P reaction time. The wet compressive strength of cements (up to 15 MPa) was close to cancellous bone. The increase in PAA content to 1 wt% caused refinement and change in the morphology of hydroxyapatite particles. Cement pastes had a high resistance to wash-out in a short time after cement mixing. The noncytotoxic character of CX cement extracts was verified. Moreover, PHYT supported the formation of Ca deposits, and the additional synergistic effect of PAA and CMC on enhanced ALP activity was found, along with the strong up-regulation of osteogenic gene expressions for osteopontin, osteocalcin and IGF1 growth factor evaluated by the RT-qPCR analysis in osteogenic αMEM 50% CXI extracts. (4) Conclusions: The fully injectable composite calcium phosphate bicements with anionic polyelectrolyte addition showed good mechanical and physico-chemical properties and enhanced osteogenic bioactivity which is a promising assumption for their application in bone defect regeneration.

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Section: Discussionsupporting

confidence: 72%

Injectable Enzymatically Hardened Calcium Phosphate Biocement

Medvecký

Štulajterová

Giretová

et al. 2020

JFB

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“…Polymers or blends having nano-sized fillers exhibits markedly improved mechanical, thermal, and optical properties when compared to pure polymers or their traditional composites. Also, improving the electrical and magnetic properties of the polymeric materials is the subject that attracts many investigators [5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…These fillers include Sb 2 O 3 [5], hydroxyapatite (HA) [6], zirconium hydroxide [8], Ag [9], and ZnO [10], cellulose nanocrystals (CNC) [28], and nanoclay [29]. Yadava et al [11] prepared graphene oxide (GO, at 1wt.%)/CMC/alginate composite with improved tensile strength and Young's modulus by 40 and 1128 %, respectively.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and investigation of the electrical and dielectric properties of Co3O4/(CMC+PVA) nanocomposite films

Sayed

El‐Gamal

2015

J Polym Res

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Cobalt oxide (Co 3 O 4 ) nanoparticles (NPs), with average crystallite size<61 nm, were prepared by a sol-gel method. Two allowed direct optical band gaps of 1.445 and 1.915 eV are found for Co 3 O 4 NPs. Sodium carboxymethyl cellulose (Na-CMC)/polyvinyl alcohol (PVA) blend was doped with Co 3 O 4 at different concentrations<1.0 wt.% to study the electrical and dielectric properties of these nanocomposite films. Scanning electron microscopy images revealed a good dispersion of Co 3 O 4 NPs on the surface of the CMC/PVA films. The current-voltage characteristics are of non-ohmic behavior. The dielectric permittivity (ε') was studied in the frequency and temperature range of 5.0 kHz-5.0 MHz and 308-408 K and was found to depend on the Co 3 O 4 content. The dielectric loss (ε^) also increases and shows wave-like behavior with increasing Co 3 O 4 ratio. Increasing Co 3 O 4 NPs content leads to the formation of more number of three-dimensional semiconducting connected networks inside CMC/PVA matrix, leading to increasing both DC and AC conductivities. The correlated barrier hopping (CBH) is the most suitable mechanism to explain the AC conduction behavior in the Co 3 O 4 / Na-CMC/ PVA nanocomposite films.

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“…The The morphology and particle size of the as-obtained HAP nanocrystal are also directly characterized by SEM (Fig. 3) that the structure and the particle size of HAP can be easy controlled by changing the amount of CMC used in the synthesis [21,28,29,31].…”

Section: Resultsmentioning

confidence: 99%

Biomimetic hydroxyapatite (HAP)/ Carboxymethyl Cellulose (CMC) composite materials for bone tissue engineering applications

Saha¹,

Bhadra²

2020

American Journal of Applied Bio-Technology Research

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Natural bone is a complex material with a well-designed architecture. To achieve successful bone integration and regeneration, the constituents and structure of bone-repairing scaffolds need to be flexible and biocompatible. Hydroxyapatite (HAp), the main constituent of bone minerals, has excellent biocompatibility, while carboxymethyl cellulose (CMC), comprised of a three-dimensional network, has high flexibility. Therefore, CMC/HAp composites have attracted attention for the advancement of bone tissue engineering. In this work, a carboxymethyl cellulose/hydroxyapatite (Ca10(PO4)6(OH)2; HAp) composite has been developed as a three dimensional scaffold for bone tissue engineering. Scanning electron microscopy revealed that the CMC/Hap composite had a sheet like structure. These results revealed that the amount of precipitated HAp in the CMC/HAp composites was affected by the amount of CMC used during preparation. Properties of composites can be improved at optimal filler content compared to the pure Hap in the perspective of various biomedical applications. We have characterized the surface morphology of the composite using SEM image and having with the observed well dispersion of Hap in the Cmc phase.

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Preparation and characterization of bioceramic nanocomposites based on hydroxyapatite (HA) and carboxymethyl cellulose (CMC)

Cited by 23 publications

References 43 publications

Injectable Enzymatically Hardened Calcium Phosphate Biocement

Injectable Enzymatically Hardened Calcium Phosphate Biocement

Synthesis and investigation of the electrical and dielectric properties of Co3O4/(CMC+PVA) nanocomposite films

Biomimetic hydroxyapatite (HAP)/ Carboxymethyl Cellulose (CMC) composite materials for bone tissue engineering applications

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