Preparation and Characterization of Biocompatible Membranes Based on TiO2 Nanoparticul

Abstract

In this study, biocompatible composite membranes of sodium alginate/hydroxypropyl methylcellulose (NaAlg/HPMC) based on nano-titanium dioxide (n-TiO2) were prepared. Regarding the preparation processes of these membranes, the amount of citric acid [5%, 15%, 30% (w/w)] added to the NaAlg/HPMC blend, the crosslinker type (glutaraldehyde, acetone/water with glutaraldehyde, CaCl2), and the amount of n-TiO2 [5%, 15%, 20% (w/w)] were studied and optimum conditions were determined. When the equilibrium swelling values were examined, it was observed that the one with the least swelling was the CaCl2 crosslinked membrane. Fourier Transform Infrared (FTIR) Spectroscopy, Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM) were used to characterize the modified crosslinked membranes. The FTIR analysis results showed the formation of hydrogen bonds between the hydroxyl groups of the HPMC and NaAlg polymer chains. The DSC analysis showed the existence of single glass transition temperature (Tg) which indicated the compatibility and physical interaction between the NaAlg and HPMC polymer chains for NaAlg / HPMC mixtures.

Quercetin‐loaded sodium alginate/collagen/h‐boron nitride potential wound dressings prepared using the Box‐Behnken experimental design

“…Moreover, NaAlg showed important absorption peaks at 2930 cm −1 , 1620 cm −1 , 1406 cm −1 , and 1047 cm −1 , which was associated with the stretching vibrations of aliphatic C–H, COO‐(symmetric), COO‐(asymmetric) and C–O, respectively. [ 50–52 ] As shown in Figure 7B, the observed absorption peaks of Col located between 3575 cm −1 and 3120 cm −1 were attributed to the N‐H stretching vibration of amide A and Amide B groups, respectively. In addition, at 1640 cm −1 observed C = O stretching vibrations group of Amide I. N‐H bending coupled with C–N stretching vibrations of Amide II was observed approximately at 1392 cm −1 .…”