Preparation and Characterization of Biocompatible Polymer Particles as Potential Nanocarriers for Inhalation Therapy

Abstract

Aim. Investigation of the possibility of manufacturing biocompatible polymer particles which have the required properties for pulmonary delivery via inhalation and simultaneously act as vehicles of nanotherapeutics. Methods. Nanostructures were obtained from biocompatible polysaccharides by successive oxidation and reactive coiling in the aqueous phase. The resultant nanosuspensions of PAD (polyaldehyde dextran) and DACMC (dialdehyde carbomethylcellulose) were used as precursors in spray drying production of powders at variable process conditions. The resultant dry microparticles were characterized by SEM observations, and their properties related to delivery by inhalation were determined by laser diffraction spectrometry following the dispersion in the commercial inhaler. Finally, the possibility of the reconstitution of nanosuspensions by powders rehydration was evaluated. Results. Synthesized nanoparticles had size of 120-170 nm. Microparticles after drying had size of 0.5-5 m and different surface morphology. Aerosolized particles obtained from powder dispersion in the inhaler had the volumetric median diameter of ∼2 and ∼1 m for PAD and DACMC, respectively. Hydration of powders led to restoring the nanosuspensions with the average particle size similar to the precursor. Conclusions. PAD and DACMC can be used to obtain nanostructures which, after processing, take a form suitable for effective delivery to the lungs via inhalation.

Formulation, Optimization, and Characterization of Biocompatible Inhalable D-Cycloserine-Loaded Alginate-Chitosan Nanoparticles for Pulmonary Drug Delivery

“…Particle size and zeta potential measurement was carried out using Nanosight NS500 computerized with nanoparticle tracking analysis (NTA), namely NTA 2.3 equipped with automated sample introduction, robotic motorized stage attached with red laser, and mounted on a CCD camera [25][26][27].…”

Particles and lungs - where chemical engineering meets medicine

“…One strategy is to optimize the properties of powder to make it easier to disperse. "Particle engineering" is the most suitable approach to do so, and it can use, e.g., the optimized spray drying process to obtain powders with controlled properties regarding their morphology, stability and aerosolization properties [9][10][11][12]. The spray drying technique also allows to produce particles with the ordered structure [13] and with certain functionality after deposition on the lung surface [14][15][16].…”

Powder Particles and Technologies for Medicine Delivery to the Respiratory System: Challenges and Opportunities

“…and Gradoń L., 2010). It can be also be beneficial to use micrometer-size nanostructured (partly porous) particles instead of compact ones with the same size (Tsapis N. et al, 2002;Jabłczyńska K. et al, 2015). All these strategies can be used both for drugs prepared as interactive mixtures (API-excipient) and for excipient-free formulations.…”