Preparation and characterization of biodegradable PLA polymeric blends

Chen, Chien‐Chung; Chueh, Juyu; Tseng, How; Huang, Haw Ming; Lee, Sheng Yang

doi:10.1016/s0142-9612(02)00466-0

Cited by 518 publications

(337 citation statements)

References 11 publications

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“…The types of ECM used in liver tissue engineering include collagen gels and polylactic acid (PLA); for the former, µ E ∼ 10 5 P a and E ′ ∼ 10 0 − 10 1 P a (Velegol and Lanni, 2001), whilst for the latter, µ E ∼ 10 5 − 10 8 P a and E ′ ∼ 10 6 − 10 9 P a (Chen et al, 2003;Gunatillake and Adhikari, 2003;Namy et al, 2004). We thus consider a range of values for these parameters.…”

Section: Parametersmentioning

confidence: 99%

A Mathematical Model of Liver Cell Aggregation In Vitro

et al. 2008

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"Authors may self-archive the author's accepted manuscript of their articles on their own websites. Authors may also deposit this version of the article in any repository, provided it is only made publicly available 12 months after official publication or later. He/ she may not use the publisher's version (the final article), which is posted on SpringerLink and other Springer websites, for the purpose of self-archiving or deposit. Furthermore, the author may only post his/her version provided acknowledgement is given to the original source of publication and a link is inserted to the published article on Springer's website. The link must be accompanied by the following text: "The final publication is available at link.springer.com"". th March, 2014A mathematical model of liver cell aggregation in vitroThe behaviour of mammalian cells within three-dimensional structures is an area of intense biological research and underpins the efforts of tissue engineers to regenerate human tissues for clinical applications. In the particular case of hepatocytes (liver cells), the formation of spheroidal multicellular aggregates has been shown to improve cell viability and functionality compared to traditional monolayer culture techniques.We propose a simple mathematical model for the early stages of this aggregation process, when cell clusters form on the surface of the extracellular matrix (ECM) layer on which they are seeded. We focus on interactions between the cells and the viscoelastic ECM substrate. Governing equations for the cells, culture medium and ECM are derived using the principles of mass and momentum balance. The model is then reduced to a system of four partial differential equations, which are investigated analytically and numerically. The model predicts that, provided cells are seeded at a suitable density, aggregates with clearly defined boundaries and a spatially uniform cell density on the interior will form. While the mechanical properties of the ECM do not appear to have a significant effect, strong cell-ECM interactions can inhibit, or possibly prevent, the formation of aggregates. The paper concludes with a discussion of our key findings and suggestions for future work.

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Section: Parametersmentioning

confidence: 99%

A Mathematical Model of Liver Cell Aggregation In Vitro

et al. 2008

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“…PDLA having a much higher degradation rate than PLLA. It degrades completely into lactic acid within a period ranging from 10 months to 4 years, depending upon its molecular weight, crystalline degree, material shape, and implantation site (Chen et al, 2003). PLLA is a rather less ductile and stiffer polymer with a low degradation rate.…”

Section: Introductionmentioning

confidence: 99%

Mechanical study of PLA–PCL fibers during in vitro degradation

Vieira

Vieira²,

Ferra

et al. 2011

Journal of the Mechanical Behavior of Biomedical Materials

224

128

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Abstract:The aliphatic polyesters are widely used in biomedical applications since they are susceptible to hydrolytic and/or enzymatic chain cleavage, leading to α-hydroxyacids, generally metabolized in the human body. This is particularly useful for many biomedical applications, particularly, for temporary mechanical supports in regenerative medical devices.Ideally, the degradation should be compatible with the tissue recovering.In this work, the mechanical properties evolution during degradation are discussed based on experimental data. The decrease of tensile strength of PLA-PCL fibers follows the same trend as the decrease of molecular weight, and so it can also be modeled using a first order equation. For each degradation stage, hyper elastic models such as neo-Hookean, MooneyRivlin and second reduced order, allowed a reasonable approximation of the material behavior. Based on this knowledge, constitutive models that describe the mechanical behavior during degradation are proposed and experimentally validated. The proposed theoretical models and methods may be adapted and used in other biodegradable materials, and can be considered fundamental tools in the design of regenerative medical devices where strain energy is an important requirement, such as ligaments, cartilage, stents or others.

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“…Because PLA is brittle, its mechanical properties have been improved by polymer blends or natural fiber reinforcing to be used extensively as bone fixation materials and structural materials. Since Poly(e-Caprolactone) (PCL) is a ductile, bioabsorbable and biodegradable polymer, many types of PLA/PCL polymer blends have been developed to improve its material strength and impact resistance [1][2][3][4]. Although good results have been reported, in most cases, the impact resistances of PLA/PCL polymer blends are based only on the experimental results of Izod impact strength test/Charpy impact strength test and Dynatup impact test/dart impact test [5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of dynamic compressive properties of PLA polymer blends using split Hopkinson pressure bar

Nishida

Yamaguchi

Todo

et al. 2009

DYMAT 2009 - 9th International Conferences on the Mechanical and Physical Behaviour of Materials Under Dynamic Loading

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Abstract. Poly(lactic acid) (PLA) has been used as a biomaterial for bone fixation devices in oral and orthopedic surgery because of good biocompatibility and bioabsorbability. Because Poly(eCaprolactone) (PCL) is a ductile, bioabsorbable and biodegradable polymer, many types of PLA/ PCL polymer blends have been developed to improve its material strength and impact resistance. The stress-strain curves of PLA and PLA/PCL polymer blends were measured using a split Hopkinson pressure bar (Kolsky bar) method and a universal testing machine. The effect of PCL content on Young's modulus and yield stress was examined. The values of constants in CowperSymonds equation with respect to yield stress were determined for PLA and PLA/PCL polymer blend specimens. PLA/PCL specimens were observed using a scanning electron microscope.

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Preparation and characterization of biodegradable PLA polymeric blends

Cited by 518 publications

References 11 publications

A Mathematical Model of Liver Cell Aggregation In Vitro

A Mathematical Model of Liver Cell Aggregation In Vitro

Mechanical study of PLA–PCL fibers during in vitro degradation

Evaluation of dynamic compressive properties of PLA polymer blends using split Hopkinson pressure bar

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