Preparation and Characterization of Biological Non-toxic Hybrid Nanoparticles Based on Lactide and Poly(ethylene glycol) Loading Docetaxel for Anticancer Drug Delivery

Li, Ruiduan; Zhang, Jianjun; Chen, Jianfeng; Teng, Wei; Wang, Jie‐Xin; Li, Caixia

doi:10.1016/j.cjche.2014.09.012

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…LI Ruiduan et al modified PLA by introducing several polymers and made the material both lipophilic and hydrophilic [10]. So It can be specialized at loading docetaxel which is an anticancer drug, and become a potential treatment for cancer.…”

Section: Drug Deliverymentioning

confidence: 99%

Exploring the utilization of polylactic acid-based materials in medicine: Contemporary innovations and trends

Zhang

2023

TNS

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A biocompatible, non-toxic substance is polylactic acid (PLA), which is also biodegradable. This material has been studied for decades and has been commercially used in some fields. The potential of defined PLA for different medical applications, including drug delivery systems, wound healing, bone implants, and vascular grafts, was described in this paper. Various methods of characterization and modification of PLA have been investigated to optimize its properties for specific applications. Typically, additional polymers are introduced into PLA to enhance its functional properties. The key feature of PLA is its capacity for degradation in the human body without introducing harmful byproducts. Adjustments to PLA composition can control degradation rates, influencing drug delivery or the persistence of implants. By applying a cold plasma treatment in order to alter the PLA-based polymer's surface, the capacity of the material to transport drugs may be changed. The change of parameters in coaxial electrospinning can produce different PLA-based products for different use. However, certain challenges remain, such as improving the adhesion of PLA and production of low-price PLA.

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Section: Drug Deliverymentioning

confidence: 99%

Exploring the utilization of polylactic acid-based materials in medicine: Contemporary innovations and trends

Zhang

2023

TNS

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“…But some practical limitations make these techniques less popular. Polymers can play significant performances in the biomedical as well as in the pharmaceutical sciences especially the plasma proteins which can act as a transporter in drug transportation 7,8 . In the pharmaceutical industries, the hot-melt extrusion method is now recognized where mixing of heated sample and subsequently shaping is carried out in a single continuous process 9 .…”

mentioning

confidence: 99%

“…Therefore, the drug performance can significantly be affected by reversible interactions of biological polymers with drugs through the modification in transport and distribution phenomenon 14 . BSA, mammalian albumin, has been extensively investigated due to its stability and neutrality in biological reactions as well as for low cost 7,8,15 . It is found from such systems that the efficiency of absorption and release of drug is a function of ionic or electrostatic interactions amongst the drug and polymers 16 .…”

mentioning

confidence: 99%

Effect of Temperature and Additives on the Interaction of Ciprofloxacin Hydrochloride Drug with Polyvinylpyrrolidone and Bovine Serum Albumin: Spectroscopic and Molecular Docking Study

et al. 2021

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The fluoroquinolone antibiotic drug namely ciprofloxacin hydrochloride (CFH) is widely prescribed for the treatment of different bacterial infections. The interaction of CFH with a synthetic polymer, polyvinyl pyrrolidone (PVP), and biopolymer, bovine serum albumin (BSA) was studied by UVvisible and fluorescence spectroscopic methods at different temperatures. The binding constant (K b ) for the CFH-PVP complex was determined from the Benesi-Hildebrand plot. PVP of different molecular weights (MW) (such as 24,000, 40,000, 360,000, and 700,000 gm. mole -1 ) were used for the interaction between CFH and PVP. There was a gradual increase in K b value and the complexation reaction was found to be much enhanced with the augmentation of the MW of PVP. The values of K b were also found to be increased with increasing temperatures as well as with the increase of electrolyte/acetic acid concentration. The Gibbs free energy of binding (∆G 0 ) values of the interaction process was negative which indicates the complex formation is thermodynamically spontaneous. The positive values of enthalpy (∆H 0 ) and entropy (∆S 0 ) of binding connote that the binding force for CFH-PVP complexation is hydrophobic in nature and the complexation is entropy controlled. The negative intrinsic enthalpy (∆H *,0 ) values indicate the high stability of CFH-PVP complexes. Molecular docking calculation discloses the existence of similar binding forces between CFH and PVP obtained by the analysis of experimental data from UV-visible spectroscopic method. The binding constant between CFH and BSA (K b ), quenching constant (K sv ), the number of binding sites (n), and the quenching rate constant (K q ) for the CFH-BSA system were also calculated. The values of K sv , K q , and n for the CFH-BSA system are lower in 0.05 mol kg -1 urea solution and higher in PVP solutions compared to those of aqueous medium.

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Therapeutic effect of magnetic nanoparticles on calcium silicate bioceramic in alternating field for biomedical application

Salmani

Hashemian

Khandan

2020

Ceramics International

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Preparation and Characterization of Biological Non-toxic Hybrid Nanoparticles Based on Lactide and Poly(ethylene glycol) Loading Docetaxel for Anticancer Drug Delivery

Cited by 4 publications

References 27 publications

Exploring the utilization of polylactic acid-based materials in medicine: Contemporary innovations and trends

Exploring the utilization of polylactic acid-based materials in medicine: Contemporary innovations and trends

Effect of Temperature and Additives on the Interaction of Ciprofloxacin Hydrochloride Drug with Polyvinylpyrrolidone and Bovine Serum Albumin: Spectroscopic and Molecular Docking Study

Therapeutic effect of magnetic nanoparticles on calcium silicate bioceramic in alternating field for biomedical application

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